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Abstract

Background: the treatment of acne vulgaris should act against hyperkeratinization, inflammation, bacterial proliferation and sebum production. At the present, there is no topical anti-acne medication that acts against all of the above pathophysiologic features of acne. The acne vulgaris response to the clindamycin is better than other available antibiotics. Kaolin by itself can be useful in sorption of bacteria, pus, toxins and free fatty acids. Aim of the study: The aim of this work is to study the role of the adsorption -desorption process in prolonging the action of the clindamycin drug. Patients and Methods: adsorption of clindamycin HCl from 70% ethanol solution on different amounts of kaolin as adsorbent was studied using UV-spectrophotometry technique at 210nm. Desorption process of the adsorbed clindamycin HCI from kaolin surface was also studied. Results: A stable formula consisting kaolin, clindamycin HCl and 70% ethanol aqueous solution has been prepared for the treatment of acne vulgaris. Conclusion: The formula provides prolonged action accompanied with a certain mechanism of clindamycin adsorbed on kaolin upon application on the skin leading to fairly good results in the treatment of acne vulgaris. The mechanism of action of the formula is based on the adsorption-desorption processes of the antibiotic on the clay

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