Abstract
The present study include a new developed method of analysis for determination of drug Spironolaction (SP) in some Pharmaceuticals by Spectrofluorometric method. Spironolaction was determined under optimal experimental condition that follows :- The excitation spectrum was ((λ=351 nm), the emmetion spectrum was (λ=518 nm), pH=1, the suitable temperature for reaction 60°C and the optimal time less than (3) minute. The analysis and rang statistical data was:-Linear dynamic rang (1-10) μg.ml-1, the detection limit (D.L = 0.023 μg.ml-1), Molar absorptivity (ɛ = 29875 liter mole-1 cm-1), Relative standard deviation (%RSD = 0.78), (%Erel = 3.3) and recovery (Rec = 96.6) percentage. Determination of Spironolactone was accomplished by two methods (A) Using direct calibration curve method, Corr. Coef. (R = 0.988 and %Rec = 97.4). (B) Using standard additional methods Corr. Coef (R =0.988 and %Rec= 96.6).
Article Type
Article
How to Cite this Article
Hossain, Fatima Ali
(2008)
"Determination Of Micro Amount Of Spironolactone In Some Of Pharmaceutical Preparate By Using a Molecular Luminescence Technique.,"
Baghdad Science Journal: Vol. 5:
Iss.
1, Article 9.
DOI: https://doi.org/10.21123/bsj.2008.5.1.55-62
