Abstract
An indirect method using electrothermal atomic absorption spectrometry (ETAAS) has been established for the determination of DFOM in the drug desferal™as DFOM-Au (III) complex. The formation of this complex at 1:1 mole ratio computed by UV-Vis spectrophotometric technique was confirmed by distinction of the IR absorption spectra between the free DFOM and its complex. Several experimental factors that effect the formation of DFOM-Au (III) complex were optimized using AA responses. Aliquots of the complex extract were injected into a coated GF and the AA-signals measured. A direct calibration graph was constructed and from which the figures of merits were found such as: LDR (0.08-3.5 µg ml-1), m0º (293.3 pg), LOD (0.0154 µg ml-1), RSD% (2.0-3.5), recovery present (101.54±0.86), and %Erel (1.54). The established indirect ETAAS was applied to analyze the drug desferal™ for the determination of DFOM using direct and standard additions procedures and DFOM found to be 488 and 484 mg/unit respectively compared to the stated value of 500 mg/unit. All statistical calculations were implemented via the chemsoftware (Minitab version 11).
Article Type
Article
How to Cite this Article
AL-Ayash, Ashraf.S.; Khammas, Zuhair A-A; and Jasim, Fadhil
(2008)
"Determination of Desferrioxamine in the Drug Desferal™ as DFOM-Au (III) Complex by Using Indirect Electrothermal Atomic Absorption Spectrometry and Other Techniques.,"
Baghdad Science Journal: Vol. 5:
Iss.
3, Article 27.
DOI: https://doi.org/10.21123/bsj.2008.11874
