Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks Mahir A. Jalal | Hadi S. Al-Lami

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Baghdad Science Journal

Abstract

In this work, novel copolymers of poly(adipic anhydride-co-mannitol) were synthesized by melting condensation polymerization of poly(adipic anhydride) with five percentages of mannitol sugar, 1 to 5 Wt.%. These copolymers were purified and then, characterized by FT-IR, which was proved that the cross-linking reaction was caused by nucleophilic attack of mannitol hydroxyl group to acidic anhydride groups of poly(adipic anhydride) backbone and new ester groups were formed and appeared. Also, modified organic-soluble chitosan, N-maleoyl-chitosan, were synthesized by grafting reaction of chitosan with maleic anhydride in DMF as solvent, and it was also purified and characterized by FT-IR. Biodegradation in vitro of the IPNs of poly(adipic anhydride-co-mannitol)-N-maleoyl chitosan networks were evaluated by hydrolytic degradation studies at three different media (PBS, SIF and SGF) for 18 weeks with 92% as maximum degradation and it was found that minimum weight loss of IPNs was noticeably shown in SIF. In addition, hydrolytic degradation percent was decreased with increasing mannitol proportions.

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Journal BS. Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks. BSJ [Internet]. 5Jun.2016 [cited 5Aug.2020];13(2.2NCC):0210. Available from: http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2767
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