Hypothyroidism and Leptin in Iraqi Patients with Chronic Kidney Disease
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Abstract
The present study aims at assessing the effects of chronic kidney disease (CKD) on thyroid hormone and leptin by evaluating the level of: leptin hormone along with thyroid hormone in CKD patients. The study has been conducted on 70 subjects, 50 patients with an age range between 20-50 years (25 males and 25 females) who were diagnosed to have CKD stage-5, and 20 normal controls whose ages ranged between 20-48 years (10 males and 10 females), who attended the Nephrology and Transplant Center in Medical City of Baghdad- Iraq from April 2018 to July 2018. The study showed a highly significant (P<0.01) increase in TSH level in CKD patients in comparison with controls. While T3 and T4 levels observed highly significant decrease (P<0.01) in CKD patients in comparison with their control groups; on the other hand, in Leptin levels, it has been demonstrated a highly significant (P<0.01) increase in CKD patients compared to the controls. Also there was a significant (P<0.05) positive correlation between TSH and Leptin, while the results showed a highly significant (P<0.01) negative correlation between T3, T4 and Leptin. To conclude, this study confirms that thyroid dysfunction and hyperleptinemia have been found to be very common in CKD patients and reveals the significant association between CKD progression and thyroid dysfunction and hyperleptinemia.
Received 6/7/2019
Accepted 25/10/2020
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Mao S, Fang, L, Liu F, Jiang S, Wu L, Zhang J. Leptin and chronic kidney diseases. J Recept Signal Transduct Res. 2018 Apr ; 38(2): 89-94.
Kannan A, Sriramakrishnan V, Kannan B, Anandan H. Thyroid Function Abnormalities in Patients with Chronic Kidney Disease - A Prospective Study. Int J Sci Stud. 2017 July; 5(4): 68-72.
Maia AL, Goemann IM, Meyer EL, Wajner SM. Deiodinases: the balance of thyroid hormone: type 1 iodothyronine deiodinase in human physiology and disease. J Endocrinol. 2011Jun ; 209(3): 283-297.
Malyszko J, Wolczynski S, Mysliwiec M. Adiponectin, leptin and thyroid hormones in patients with chronic renal failure and on renal replacement therapy: are they related?. Nephrol Dial Transplant. 2006 Jan; 21(1): 145-152.
Keerthana BL, Kumar TA. Study of Thyroid and Lipid Profile in Chronic Kidney Disease. Int J Med Health Res. 2016 Mar; 2(3): 6-9.
Montazerifar F, Mansour K, Zahra H, Mahla P. Study of serum levels of leptin, C-reactive protein and nutritional status in hemodialysis patients. Iran Red Crescent Med J. 2015 Aug; 17(8): 1-5.
Shankar A, Syamala S, Xiao J, Muntner P. Relationship between plasma leptin level and chronic kidney disease. Int J Nephrol. 2012 May; 2012(6): 1-6.
Gunta SS, Mak RH. Ghrelin and leptin pathophysiology in chronic kidney disease. Pediatr Nephrol, 2013 Apr; 28(4): 611-616.
Suneja M, Murry DJ, Stokes JB, Lim VS. Hormonal regulation of energy-protein homeostasis in hemodialysis patients: an anorexigenic profile that may predispose to adverse cardiovascular outcomes. Am J Physiol Endocrinol Metab. 2011 Jan; 300 : 55-64.
Tsai J. The association of serum leptin levels with metabolic diseases. Tzu Chi Med J. 2017 Oct-Dec; 29 (4): 192-196.
Hossain MM, Shah K, Begum N, Ahmed P. Islam, A.K. and Chowdhury, N.I. Thyroid Functional Status in Chronic Kidney Disease. Bangladesh J Nucl Med (2015); 18(2):141-144
Briffa JF, McAinch AJ, Poronnik P, Hryciw DH. Adipokines as a link between obesity and chronic kidney disease. Am J Physiol Renal Physiol. 2013 Dec; 305(12):1629-1636.
Yaman H. Low triiodothyronine alters flow mediated vasodilatation in advanced nondiabetic kidney disease. Am J Nephrol. 2011; 33(1):25-32.
Tsimihodimos V, Mitrogianni Z, Elisaf M. Dyslipidemia Associated with chronic kidney disease. Open Cardiovasc Med J. 2011 Feb; 5(1): 41-48.
Rajeev G, Chickballapur RW, Vijayalakshmi R, Swathi M, Kumar S. Evaluation of thyroid hormone levels in chronic kidney disease patients. Saudi J Kidney Dis Transpl. 2015 Jan; 26(1): 90-93.
Singh N, Kaur S, Jain A, Thakur A. Serum C-reactive protein and leptin for assessment of nutritional status in patients on maintenance hemodialysis. Indian J Nephrol. 2012 Nov-Dec; 22(6): 419-423.
Swaminathan K, Rajesh S, Avudaiappan S. A Study of Thyroid Function Abnormalities in Patients with Chronic Kidney Disease. J Dent Med Sci. 2016 Aug; 15(8): 7-15.
Khatiwada S, Rajendra KC, Gautam S, Lamsal M, Baral N. Thyroid dysfunction and dyslipidemia in chronic kidney disease patients. BMC Endocr Disord. 2015 Oct; 15(1): 65.
Aminzadeh MA, Pahl MV, Barton CH, Nosratola NS, Vaziri D. Human uraemic plasma stimulates release of leptin and uptake of tumour necrosis factor-α in visceral adipocytes . Nephrol Dial Transplant. 2009 Dec ; 24(12): 3626-3631.
Kalantar-Zadeh K. So, Is Leptin Good or Bad in Chronic Kidney Disease? OBESITY. 2007 Jun; 15(6): 1343-1344.
Kuczera P, Adamczak M, Wiecek A. Endocrine abnormalities in patients with chronic kidney diseases. Sec. of Med. Sci, 2015; 36(2): 109-118.
Ghazizadeh SH, Lesanpezeshki M.Reproduction in Women with End-Stage Renal Disease and Effect of Kidney Transplantation. Iran J Kidney Dis. 2007 Jul; 1(1): 12-15.
Bates SH, Myers MG. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab. 2003 Dec; 14(10): 447-452.
Choobineh H, Dehghani SJ, Alizadeh S, Ghobadi DV, Saiepour N, Meshkani R. Evaluation of Leptin Levels in Major beta-Thalassemic Patients. IJHOSCR. 2009 Jan; 3(4):1-4.
Shahramian I, Noori N, Ramezani A, Sharafi E, Akhlaghi E. Correlation between serum leptin level and thyroid hormones in children with major beta-thalassemia. Iran J Ped Hematol Oncol. 2013 Oct; 3(4):149-153.
Hsieh CJ, Wang PW, Wang ST, Liu RT, Tung SC, Chien WY. Serum leptin concentrations of patients with sequential thyroid function changes. Clin Endocrinol (Oxf). 2002 Jul; 57(1): 29-34.
Corbetta S, Englaro P, Giambona S, Persani L, Blum WF, Beck-Peccoz P. Lack of effects of circulating thyroid hormone levels on serum leptin concentrations. Eur J Endocrinol. 1997 Dec ; 137(6): 695-663.
Ibrahim MK, Al-Samarrai AH, Khudhair KA. Association Between Leptin Hormone and Thyroid Hormone Levels in Hypothyroid, Hyprethyroid and Euthyroid Subjects. Front Biomed Sci. 2016 Oct; 1(2): 39-44.