دراسة الطرز الوراثية لجين Aryl Hydrocarbon Receptor-Interacting ‎Protein (AIP) ‎(rs641081 C>A) في عينات عراقية ضخمة الاطراف مصابة بورم الغدة النخامية

Russ S, Shafiq I. Pituitary Adenoma. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Feb 4. PMID: 32119338 , Bookshelf ID: NBK554451

Makri A, Lodish M. Gigantism and Acromegaly. In Pituitary Disorders of Childhood. Humana Press, Cham. 2019: 121-139 p.

‎3. Al-Yasseri BJ, Rahmah AM, Al-Saffar NS. Acromegaly in Iraq: Brief look on epidemiology, comorbidities and management. J Contemp Med Sci 2019Jun28;5(3):136-139, doi.org/10.22317/jcms.06201903

Chris Yedinak1, Karen J. Pulaski-Liebert, Daphne T. Adelman , Jessica Williams. Acromegaly: current therapies benefits and burdens. Clin. Pract. (2018) 15(2), 499-511.

Daly AF, Rostomyan L, Betea D, Bonneville JF, Villa C, Pellegata NS, et al.,. AIP-mutated acromegaly resistant to first-generation somatostatin analogs: long-term control with pasireotide LAR in two patients. Endocrine Connections J., 2019 Apr 1; 8(4): 367-77. DOI: 10.1530/EC-19-0004

Rostomyan L, Daly AF, Petrossians P, Nachev E, Lila AR, Lecoq AL, Lecumberri B, Trivellin G, Salvatori R, Moraitis AG, Holdaway I. Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients. Endocr Connect. 2015 Oct 22(5): 745-57. DOI: 10.1530/ERC-15-0320

Lenders NF, McCormack AI, Ho KK. Management of endocrine diseases: does gender matter in the management of acromegaly. Eur J Endocrinal. 2020 May 1; 182(5): R67-82. DOI: 10.1530/EJE-19-1023

Colao A, Amato G, Pedroncelli AM, Baldelli R, Grottoli S, Gasco V et.al. Gender-and age-related differences in the endocrine parameters of acromegaly. J Endocrinol Invest. 2002 Jun; 25(6): 532-8. DOI: 10.1007/BF03345496

Colao A, Grasso LF, Giustina A, Melmed S, Chanson P, Pereira AM et al. Nat Rev Dis Primers. 2019 Oct 21;5(1):72. doi: 10.1038/s41572-019-0129-5DOI: 10.1038/s41572-019-0071-6

Yarman S, Ogret YD, Oguz FS. Do the aryl hydrocarbon receptor interacting protein variants (Q228K and Q307R) play a role in patients with familial and sporadic hormone-secreting pituitary adenomas. Genetic testing and molecular biomarkers, 19(7),394–398. doi: 10.1089/gtmb.2014.0333

García-Guzmán B, Portocarrero-Ortiz L, Dorantes-Argandar AA, Mercado M. Hereditary Pituitary Tumor Syndromes: Genetic and Clinical Aspects. Rev Invest Clin., 2020; 72(1): 8-18. DOI: 10.24875/RIC.19003186

Daly AF, Vanbellinghen JF, Khoo SK, Jaffrain-Rea ML, Naves LA, Guitelman MA et.al. Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families. J Clin Endocrinol Metab., 2007 May 1; 92(5): 1891-6. DOI: 10.1126/science.1126100.

Vierimaa O, Georgitsi M, Lehtonen R, Vahteristo P, Kokko A, Raitila A et.al . Pituitary adenoma predisposition caused by germline mutations in the AIP gene. Science, 2006 May 26; 312(5777): 1228-30. DOI: 10.1126/science.1126100

Georgitsi M, Heliovaara E, Paschke R, Kumar AV, Tischkowitz M, Vierimaa O et.al . Large genomic deletions in AIP in pituitary adenoma predisposition. J Clin Endocrinol Metab., 2008 Oct 1; 93(10): 4146-51.doi.org/10.1210/jc.2008-1003

Rowlands CJ, Staskal DF, Gollapudi B, Budinsky R. The human AHR: identification of single nucleotide polymorphisms from six ethnic populations. Pharmacogenet Genomics. 2010 May 1; 20(5): 283-90. DOI: 10.1097/fpc.0b013e32833605f8

Shah SS, Aghi MK. The Role of Single-Nucleotide Polymorphisms in Pituitary Adenomas Tumorigenesis. Cancers (Basel). 2019 Dec 9;11(12):1977.DOI: 10.3390/cancers11121977

Chen B, Liu P, Hujber EJ, Li Y, Jorgensen EM, Wang ZW. AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor. Nat Commun. 2017 Nov 9; 8(1): 1-4. DOI: 10.1038/s41467-017-01704-z

Salvatori R, Radian S, Diekmann Y, Iacovazzo D, David A, Gabrovska P et.al. In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism. Eur J Rndocrinol., 2017 Sep 1; 177(3): 257-66. doi: 10.1530/EJE-17-0293

Schernthaner-Reiter MH, Trivellin G, Stratakis CA. Interaction of AIP with protein kinase A (cAMP-dependent protein kinase). Hum Mol Genet., 2018 Aug 1; 27(15): 2604-13. DOI: 10.1093/hmg/ddy166

Bilbao Garay I, Daly AF, Egaña Zunzunegi N, Beckers A. Pituitary Disease in AIP Mutation-Positive Familial Isolated Pituitary Adenoma (FIPA): A Kindred-Based Overview. J Clin Med., 2020 Jun; 9(6): 2003. doi: 10.3390/jcm9062003

Hara T, Kanasaki H, Oride A, Moriyama M, Kyo S. Case of a woman with acromegaly whose presenting complaint was prolonged post‐partum amenorrhea. J Obstet Gynaecol Res., 2016 Oct; 42(10): 1379-84. DOI: 10.1111/jog.13065

Kelberman, D., Rizzoti, K., Lovell-Badge, R., Robinson, I. C., & Dattani, M. T. (2009). Genetic regulation of pituitary gland development in human and mouse. Endocr. Rev , 30(7): 790–829. https://doi.org/10.1210/er. 2009-0008

‎23. Mahmood AR, Abdullah MR, Abdullah KT. Determination of Some Biochemical Parameters of Acromegalic Patients with Type 2 Diabetes Mellitus. J Pharm Sci., 2019 Mar 1; 11(3): 787-90. https://www.jpsr.pharmainfo.

Gadelha MR, Kasuki L, Lim DS, Fleseriu M. Systemic complications of acromegaly and the impact of the current treatment landscape: an update. Endocr Rev., 2019 Feb; 40(1): 268-332. DOI: 10.1210/er.2018-00115

‎25. Bollerslev J, Heck A, Olarescu NC. Management of endocrine disease: individualised management of acromegaly. Eur J Endocrinol . 2019 Aug 1; 181(2): R57-71. DOI: 10.1530/EJE-19-0124

Clemmons DR, Chihara K, Freda PU, Ho KK, Klibanski A, Melmed S et.al. Optimizing control of acromegaly: integrating a growth hormone receptor antagonist into the treatment algorithm. J Endocrinol Metab., 2003 Oct 1; 88(10): 4759-67. https://doi.org/10.1210/jc.2003-030518

Alexandraki KI, Grossman AB. Management of hypopituitarism. J Clin Med. 2019 Dec; 8(12):2153. DOI: 10.3390/jcm8122153

Holdaway IM, Rajasoorya RC, Gamble GD. Factors influencing mortality in acromegaly. J Clin Endocrinol Metab. 2004 Feb 1; 89(2): 667-74. DOI: 10.1210/jc.2003-031199

Bilbao Garay I, Daly AF, Egaña Zunzunegi N, Beckers A. Pituitary Disease in AIP Mutation-Positive Familial Isolated Pituitary Adenoma (FIPA): A Kindred-Based Overview. J Clin Med. 2020 Jun; 9(6): 2003. doi: 10.3390/jcm9062003

Jemel M, Alaya W, Boubaker F, Berrich O, Zantour B .Pituitary Apoplexy. InPituitary Diseases Intech Open. London, UK. Published: March 13th 2019, DOI: 10.5772/intechopen.77270

‎31. Marques P, Caimari F, Hernández-Ramírez LC, Collier D, Iacovazzo D, Ronaldson A, Magid K, Lim CT, Stals K, Ellard S, and Grossman AB. Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors. J Endocrinol Metab., 2020 Jun 1; 105(6): e2247-60 https://doi.org/10.1210/clinem/dgaa040.

Ciresi A, Guarnotta V, Campo D, Giordano C. Hepatic steatosis index in acromegaly: correlation with insulin resistance regardless of the disease control. Int J Endocrinol., 2018 Dec 19; 2018. DOI: 10.1155/2018/5421961

Lewiński A, Marcinkowska M, Brzeziańska E, Jeziorowska A, Włoch J, Brzeziński J. Expression of Insulin‐like Growth Factor I (IGF‐I) Gene and of Genes for IGF‐Binding Proteins 1, 2, 3, 4 (IGFBP‐1—IGFBP‐4) in Non‐neoplastic Human Thyroid Cells and in Certain Human Thyroid Cancers. Effect of Exogenous IGF‐I on This Expression. Endocr Res., 2004 Jan 1; 30(1): 47-59. DOI: 10.1081/erc-120028484

Karagiannis A, Kassi E, Chatzigeorgiou A, Koutsilieris M. IGF Bioregulation System in Benign and Malignant Thyroid Nodular Disease: A Systematic Review. In Vivo., 2020 Nov-Dec; 34(6): 3069-3091. DOI: 10.21873/invivo.12141

Wolinski K, Czarnywojtek A, Ruchala M. Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly–meta-analysis and systematic review. PLoS One. 2014 Feb 14; 9(2): e88787. DOI: 10.1371/journal.pone.0088787

dos Santos MC, Nascimento GC, Nascimento AG, Carvalho VC, Lopes MH, Montenegro R et.al. Thyroid cancer in patients with acromegaly: a case–control study. Pituitary. 2013 Mar; 16(1):109-14. DOI: 10.1007/s11102-012-0383-y

‎37. Dhefer IH, Rudha Abass SA, Ahmed NS. Comparative Study of Aromatase Activity Level in Male Patients with Active Acromegaly. Int J Chem Sci. 2017; 15(2): 131. www.tsijournals.com | June-2017

Padova G, Borzì G, Incorvaia L, Siciliano G, Migliorino V, Vetri M, et al.Prevalence of osteoporosis and vertebral fractures in acromegalic patients. Clin Cases Miner Bone Metab. 2011 Sep-Dec; 8(3): 37–43 PMID: 22461828 PMCID: PMC3279059

Verhelst J, Velkeniers B, Maiter D, Haentjens P, T’Sjoen G, Rietzschel E et.al. Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly. Eur J Endocrinol., 2013 Jan 17; 168(2): 177-84. DOI: 10.1530/EJE-12-0753

Reid IR. Relationships between fat and bone. Osteoporos Int., 2008 May; 19(5):595-606. DOI: 10.1007/s00198-007-0492-z

Berg C, Petersenn S, Lahner H, Herrmann BL, Buchfelder M, Droste M et.al. Cardiovascular risk factors in patients with uncontrolled and long-term acromegaly: comparison with matched data from the general population and the effect of disease control. J Clin Endocrinol Metab., 2010 Aug 1; 95(8):3648-56. DOI: 10.1210/jc.2009-2570

Khaleel Fayhaa M, AL-Shammri Ihsan A, Mohammed Nour AL-Huda G. Estimation of Testosterone, Estradiol and some Markers in Sera of Iraqi Patients with Benign Prostatic Hyperplasia.: Fayhaa M.Khaleel|Ihsan A.AL-Shammri|Nour AL-Huda G. Mohammed. Baghdad Sci J. Daly AF, Rostomyan L, Betea D, Bonneville JF, Villa C, Pellegata NS, et al.,. AIP-mutated acromegaly resistant to first-generation somatostatin analogs: long-term control with pasireotide LAR in two patients. Endocrine Connections J., 2019 Apr 1; 8(4): 367-77. DOI: 10.1530/EC-19-0004, 2013; 10(4), 1162-1171.

Hashim Nidhal A, Khalifa Ahmed A, Mohammed Mukhtar K.. Evaluation of Sex Hormone Levels in B enign Prostatic Hyperplasia Patients Treated with 5 Alpha-Reductase Inhibitor (Finasteride) in Amara city/Iraq. Baghdad Sci J., 2020; 17(1): 1-8. https://doi.org/10.21123/bsj.2020.17.1.0001