Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients
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Abstract
Adenosine deaminase (ADA; Ec: 3.5.4.4), 5´- Nucleotidase (5´– NT; Ec: 3.1.3.5), and AMP – amino hydrolase (AMP – deaminase AMPDA; Ec: 3.5.4.6) activities were measured in sera of ovarian cancer patients before surgery, and after chemotherapy.
The results indicated that ADA specific activity increased significantly (P<0.05), while 5´-NT and AMPDA specific activity decreased significantly
(P<0.05) in ovarian cancer patients before surgery in comparison with those of their corresponding control women and benign tumors groups.
When the activities of these enzymes were measured after chemotherapy, a significant decrease (P<0.05) in ADA activity, and a significant increase (P<0.05) in 5´- NT and AMPDA activities were found in comparison with those before surgery.
The results indicated that ADA specific activity increased significantly (P<0.05), while 5´-NT and AMPDA specific activity decreased significantly
(P<0.05) in ovarian cancer patients before surgery in comparison with those of their corresponding control women and benign tumors groups.
When the activities of these enzymes were measured after chemotherapy, a significant decrease (P<0.05) in ADA activity, and a significant increase (P<0.05) in 5´- NT and AMPDA activities were found in comparison with those before surgery.
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Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients. Baghdad Sci.J [Internet]. 2010 Sep. 5 [cited 2024 Nov. 16];7(3):1166-73. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1086
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How to Cite
1.
Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients. Baghdad Sci.J [Internet]. 2010 Sep. 5 [cited 2024 Nov. 16];7(3):1166-73. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1086
