Synthesis Characterization and Adsorption of doxorubicin hydrochloride on SiO2 nanoparticle for drug delivery
DOI:
https://doi.org/10.21123/bsj.2024.10048Keywords:
Adsorption, doxorubicin, drug delivery, SiO2 nanoparticle, sol gol methodAbstract
In the present study, Tetraethyl orthosilicate (TEOS), polyethylene glycol 5%, and HCl 0.001 N are used to chemically create silica nanoparticles (SiO2 NPs). The manufacturing of nano silica-gel doxorubicin (DOX) loaded silica nanoparticles (DOX/ SiO2), which is commonly applied as part of the drug delivery systems in cancer therapy, was done using the sol-gel method. The morphology and surface content of the produced DOX/ silica loaded nanoparticles were studied using different techniques including the X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), and the Fourier Transform Infra-Red (FTIR) spectroscopy spectrum. The synthesized DOX/SiO2 has a diameter of 38 nm. The isothermal adsorption follows the Freundlich isotherm and the adsorption kinetics fit to the pseudo-second order. The R2 values for the Freundlich and Langmuir models were 0.9931 and 0.9731, respectively, showing that the Freundlich isotherm tends to be more suitable with the experimental data as compared to the Langmuir model. This study aims at using nanotechnology in drug delivery. A drug delivery system is characterized as a formulation or a device that facilitates the delivery of a medicinal substance into the body, enhancing its safety and efficacy through the regulation of the rate, time, and site of drug release into the body.
Received 27/10/2023
Revised 18/05/2024
Accepted 20/05/2024
Published Online First 20/08/2024
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