Association of ADIPOQ +45 T/G Polymorphism with Circulating Adiponectin Levels and Obesity in Iraqi Women with Gestational Diabetes Mellitus
DOI:
https://doi.org/10.21123/bsj.2024.10234Keywords:
Adipokines, Glucose intolerance, Hyperlipidemia, Hypoadiponectinemia, Obesity,Pregnancy.Abstract
The dysregulation of pro- and anti-inflammatory adipokines contributes to insulin resistance which is the main feature of the pathogenesis of gestational diabetes mellitus (GDM). This study aimed to examine the potential association of circulating concentrations of adiponectin- anti-inflammatory adipokine- and the ADIPOQ (rs2241766 T/G) polymorphism with obesity and the risk of developing GDM in the Iraqi population. 50 pregnant women diagnosed with GDM and 50 healthy pregnant women who were attending the Pregnancy Care and Maternal Medicine Outpatient Departments at Baghdad Teaching Hospital, Medical city, Baghdad/Iraq were enrolled in this study from December 2022 to May 2023. Serum adiponectin levels were estimated by immunological assay. Genotyping of ADIPOQ (rs2241766) polymorphism was performed by Taqman Real Time polymerase chain reaction (RT-PCR) technique. The (TG+GG) genotype at the rs2241766 conferred an increased risk of GDM with 41 (82%) of GDM women had TG+GG compared to 20 (40%) of normal pregnant women: [odds ratio (OR): 6.8; 95% confidence interval (CI) 2.7317 to 17.0935; P<0.001]. Compared with women in the highest quartile of total adiponectin, women in the median (50th) quartile had a fourfold increase in risk of GDM: [Odd ratio (OR): 4.093; 95% CI: (1.160 to 14.433); P<0.05]. Women who had the G allele at the ADIPOQ rs2241766T/G may be more predisposed to develop GDM due to hypoadiponectinemia, irrespective of maternal Body Mass Index (BMI). Low adiponectin levels were associated with a BMI of ≥30 kg/m2, suggesting an influential role of the anti-inflammatory adipokine on GDM risk and insulin sensitivity.
Received 19/11/2023
Revised 26/01/2024
Accepted 28/01/2024
Published Online First 20/08/2024
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