Determination of glutathione peroxidase (GSH-Pex) activity in sera & RBCs of Iraqi Women With Breast Tumors
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Abstract
Breast tumor patients generally have more oxidative stress than normal females. This was clear from non significant decrease in RBCs and serum of GSH-Pex activity in all groups of patients. The study had found that free radicals in malignant breast tumors were higher than benign tumors; therefore the GSH- Pex might be used as markers for prognosis of the disease.
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JEC Underwood, 1989: General & systematic pathology (3rd ed.). Harcourt Publishers limit china. pp=760
Kinnula V. L., Gapo J. D. & Raivio K. O.1989.: Generation & disposal of reactive oxygen metabolites in the lung. Lab. Invest. 73: 3-19.
O. Epp, R. Landensetein, A. Wendel,1989: Eur, J. Bio. Chem. 133: 51.
Cohen and Hochstein P. 1989: Glutathione peroxidase: The primary agent for the elemination of hydrogen peroxide in erythrocytes. Biochem. J. 2: 1420.
Hill A. S., Haut A., Carwright G. E., and Wintrobe M. M. 1989: The role of monhemoglobin proteins & reduced glutathione in the protection of hemoglobin from oxidation in vitro. J. Clin. Inv. 43: 17.
Imai H., K. Narashima, M. Arai, H. Sakamoto, N. Chiba, Y. Nakagawa: 1989; Over expressed phospholipid hydroperoxide scavenge by glutathione peroxidase. J. Biol. Chem.; 273: 1990-1997.
Flohe L., Gunzler W. A., Schock H. H. 1989: Glutathione peroxidase: a seleno enzyme. FEBSLett. 32: 132-134.
Rotuck J. T., Pope A. L., Ganther H. E., Swanson A. B., Hafeman D. G., Hoekstra W. G. 1989: Selenium: Biochemical role as a component of glutathione peroxidase. Science 179: 588-590.
Ursin F., Malorino M., Valente M., Ferri L., Gregoline C. 1989: Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphotidyicholine hydroperoxidase. Biochem. Biophys, Acta. 710: 197-211.
Brigelines- Flohe R., Aumann K. D., Blocker H., Gross G. 1989: phopholipid hydroperoxide glutathione peroxidase genomic DNA, CDNA. And deduced amino acid sequence. J. Biol. Chem.; 269: 7342-7348.
Takahashi K., Avissar N., Wehitin J., Cohen H. 1989: Purification and characterization of human plasma glutathione peroxidase: a seleno glyco protein distinct from the known cellular enzyme. Arch. Biochem. Biophys. 256: 677-686.
Chu F. F., Doro show J. H., Eswothy R. S. 1989: Expression, characterization, and tissue distribution of a new cellular selenium- dependent glutathione peroxidase, GSH-Pex-GI. J. Biol. Chem. 268: 2571-2576.
Shichi H., Demar J. C. 1989: non- selenium glutationine peroxidase activity from bovine ciliary body. ExEye. Res. 50: 513-520.
Fisher A. B., Dadia C., Manevich Y. Chen T. W., and Feinstein S. I. 1989: Phospholipid hydro peroxides are substrates for non selenium glutathione peroxidase. J. Biol. Chem. 274: 21326-21334.
Biornstedt M., Xue T., Huang W., Akesson B., and Holmgren A. 1989: The thioredoxion and glutaredoxin systems are efficient electron donors to human plasma glutatione peroxidase. J. Bio. Chem. 269: 29382-29384.
Brigelias- Flohe R. 1989: Tissue- specific functions of individual glutathione peroxidase. Free radic. Biol. Med. 27: 951-985.
Chu F. F., Esworthy R. S., Lee L., Wilczynski S. 1989: Retinoic acid induces Gpexz gene expression in MCF-7 human breast cancer cells. J. Nutr. 129(10): 1846-1854.
Alan M. D., Ya Jun H., 1989: Role of GSH-Pex, in breast cancer. Cancer Res. 63: 3347-3351.
Ian D. K. Halkerstone, 1989 : Biochemistry (2nd ed.). Harwall publishing company, Media, Pennsylvania, chap. 11; pp: 147-156.
Khuder S. A., Ph.D. 1989: Quality of life among women with breast cancer. Nursing College, Baghdad University.
Paglia D. E., Vanlentin W. N. 1989: Studies on the quantitative & qualitative characterization of erythrocyte. Glutathione peroxidase. J. Lab. Clin. Med. 70: 158.
Pleban P. A., Munyani A., Beachum J. 1989: Determination of selenium concentration & glutathione peroxidase activity in plasma & erythrocytes. Clin. Chem. 28: 311-316.
Hopkins J., and Tudhope G. R. 1973: GSH- Pex in human red cells in health. Br. J. Haemat. 25: 563.
Kazuo A., Takayuki U., Osamu T.1989: Production of glutathione- Peroxidase by mucorhiemalis. Agric. Biol. Chem. 47(6): 1269-1273.
Balazs N. and Zoltan G. 2004 Glitathion –dependant reduction of aesenate in human erythrocyte- a Process independent of purine nucleoside phosphorylase. Toxicological Sceinces ., 82(2) : 419-428.
Pansarasa O., Betrorelli L., Vecchiet J., Felzani G., marzatico F.1989: Age- dependent changes of antioxidant activities & Markers of free radical damage in human skeletal muscle. Free. Radic. Biol. Med. 27(5-6): 617-622.
Simsek M., Naziroglu M., Simsek H., Cay M., Aksakal M., Kumru S., 1989; Cell Biochem. Funct. 16: 227-231.
Senkurker S., Karahalil B., Inal M., & et al: FEBS Lett. 1997; 27, 416(3): 286-290.
Gavriliuk L. A., and Shraiman M. L.1992. The GSH enzymatic redox system in the blood of patients with lymphoproliferative disease. Vopr- Onkol. 38(11): 1304-1308.
Seven A., Erbil Y., Seven R., Inci F., Gulgasar T., barutcu B., Candan G. 1989:Breast cancer & benign breast disease. Cancer- Biochem- Biophys16(4): 333-345.
Arruda V. R., Salles T. S., Costa F. F. & Saad S. T.: Neoplasm. 1996; Overexpression of GssG-Red extends survival transgenic Drosophila mehnogaster under hypoxia but not normoxia 43(2): 99-102.
Ferreiria A.L.A,; Machado P.E.A.;Mastubara l.S.1999. Lipid peroxidation , antioxidant enzymes and glutathione level in human erythrocytes exposed to cooloidal iron hydroxide in vitro; Brazilian Journal of Medical and Biological Research;32(6), 689-694.
Jassem B. T., MSc. Thesis 2001;: Oxidative stress and erythrocyte glutathione defense system in chidhood acute lymphocytic leukemia. Science College, Baghdad University,
Gary E., Virginia P., Subir K.,Kistina E., and Raymond F.2005 Selenoprotein P is Requried for mouse Sperm Development; 73, 201-211.