Fat Mass and Obesity Association gene Polymorphism in PCOS Iraqi Women

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Qais Ahmed Ibraheem
Luma Hasan Alwan Al Obaidy
Gulboy Abdolmageed Nasir
Manal Taha Al Obaidi


             Polycystic syndrome (PCOS) is a considerable infertility disorder in adolescents and adult women in reproductive age. Obesity is a vigorous risk factor related to POCS.  This study aims to evaluate the association of obesity and PCOS by investigating several parameters including:  anthropological, biochemical (lipid profile, fasting blood sugar, glucose tolerance test, and hormone levels (LH, FSH, LH/FSH ratio, Estradiol2 and Testosterone),and genetic parameters (Fat mass and Obesity associated gene (FTO) polymorphism at rs17817449) in 63 obese and non-obese PCOS women. The biochemical tests were investigated by colorimetric methods while FTO gene polymorphism was detected by PCR–RFLP.  Lipid profile, FBS, GTT, hormones (LH, LH/FSH ratio) in obese PCOS patients were significantly higher than non-obese non PCOS patients. It was found that the FTO variant TT risk genotype is a predisposing factor to obesity but not for PCOS. The study substantiated a possible familial risk factor for developing obesity among women in the same family.


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Ibraheem QA, Al Obaidy LHA, Nasir GA, Al Obaidi MT. Fat Mass and Obesity Association gene Polymorphism in PCOS Iraqi Women. Baghdad Sci.J [Internet]. 2020Sep.8 [cited 2021Mar.2];17(3(Suppl.):1103. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/4642