Main Article Content
Mesoporous silica (MPS) nanoparticle was prepared as carriers for drug delivery systems by sol–gel method from sodium silicate as inexpensive precursor of silica and Cocamidopropyl betaine (CABP) as template. The silica particles were characterized by SEM, TEM, AFM, XRD, and N2adsorption–desorption isotherms. The results show that the MPS particle in the nanorange (40-80 nm ) with average diameter equal to 62.15 nm has rods particle morphology, specific surface area is 1096.122 m2/g, pore volume 0.900 cm3/g, with average pore diameter 2.902 nm, which can serve as efficient carriers for drugs. The adsorption kinetic of Ciprofloxacin (CIP) drug was studied and the data were analyzed and found to match well with pseudo-first order kinetic model. The CIP drug-loaded mesoporous silica (CIP-mSiO2) nanoparticles has capacity of about 16.3 mg drug/ mg mSiO2 were achieved, and capable of releasing 26% and 98.6% of their drug content after 90 min in water and PBS solution(pH,7.4) respectively. In-vitro controlled release studies of CIP in Simulated Body Fluid were carried out under stirring conditions. A study on release kinetics and mechanism using Koresmeyer-Pepps model, first order kinetic, and kopcha model shows that the Korsmeyer-Peppas and Kopcha models, both conform more closely to the release data.
Received 29/1/2020, Accepted 2/4/2020, Published Online First 11/1/2021
This work is licensed under a Creative Commons Attribution 4.0 International License.
Eren ZS, Tunçer S, Gezer G, Yildirim LT, Banerjee S, Yilmaz A. Improved solubility of celecoxib by inclusion in SBA-15 mesoporous silica: Drug loading in different solvents and release. Micropor. Mesopor. Mat. 2016;235: 211-223.
Borba PA, Pinotti M, de Campos CE, Pezzini BR, Stulzer HK. Sodium alginate as a potential carrier in solid dispersion formulations to enhance dissolution rate and apparent water solubility of BCS II drugs. NIH. 2016;137: 350-359.
Nozohouri S, Shayanfar A, Cárdenas ZJ, Martinez F, Jouyban A. Solubility of celecoxib in N-methyl-2-pyrrolidone+ water mixtures at various temperatures: experimental data and thermodynamic analysis. Korean J. Chem. Eng. 2017;34(5): 1435-1443.
Niemelä E, Desai D, Nkizinkiko Y, Eriksson JE, Rosenholm JM. Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells. Eur. J. Pharm. Biopharm. 2015;96: 11-21.
Madaan K, Lather V, Pandita D. Evaluation of polyamidoamine dendrimers as potential carriers for quercetin, a versatile flavonoid. Drug Deliv. 2016;23(1): 254-262.
Sood J, Sapra B, Tiwary AK. Microemulsion transdermal formulation for simultaneous delivery of valsartan and nifedipine: formulation by design. IJPPT. 2017;18(6): 1901-1916.
Deng J, Staufenbiel S, Bodmeier R. Evaluation of a biphasic in vitro dissolution test for estimating the bioavailability of carbamazepine polymorphic forms. Eur. J. Pharm. Sci. 2017;105: 64-70.
Ghadi R, Dand N. BCS class IV drugs: Highly notorious candidates for formulation development. J. Control Release. 2017;248: 71-95.
Zhang H, Li Z, Xu P, Wu R, Wang L, Xiang Y, et al. Synthesis of novel mesoporous silica nanoparticles for loading and release of ibuprofen.J. Control Release, 2011; 152: e1–e132.
Meysam M K, Seyed AM. Preparation and Characterization of Rifampin Loaded Mesoporous Silica Nanoparticles as a Potential System for Pulmonary Drug Delivery. IJPR.2015: 14 (1): 27-34.
Hamdallah AH, Dua’a MM, Fatma ZT. Evaluation of mesoporous silicate nanoparticles for the sustained release of the anticancer drugs: 5-fluorouracil and 7-hydroxycoumarin. J. Sol-Gel Sci. Techn. June 2016. DOI:10.1007/s10971-016-4127-8
Ronhovde CJ. Biomedical applications of mesoporous silica particles. PhD thesis, University of Iowa, 2017.
Adhikari C, Mishra C, Nayak D, Chakraborty A. Drug delivery system composed of mesoporous silica and hollow mesoporous silica nanospheres for chemotherapeutic drug delivery. J. Drug Deliv. Sci. Techn. 2018; 45: 303-314
Cicily JR. Biomedical Applications of Mesoporous Silica Particles, Ph.D. Thesis, The University of Iowa, Iowa City, Iowa; 2017:31.
Ciesla U , Schuth F. Ordered mesoporous materials. Micropor. Mesopor. Mat. 1999; 27: 131-149.
Tseng RL, Wu FC, Juang RS. Liquid-phase adsorption of Dyes and Phenols using Pinewood Based Activated Carbons. Carbon, 2003;41: 487-495.
Lagergren S. About the theory of so-called adsorption of soluble substances. KSven Vetenskapsakad Handl. 1898;24: 1-39.
Chiou MS , Li HY. Adsorption Behaviour of Reactive Dye in Aqueous Solutions on Chemical Cross Linked Chitosan Beads. Chemosphere, 2003;50: 1095-1105.
Weber WJ , Morris JC. Kinetics of Adsorption on Carbon from Solution. JSEDA. 1963;89: 31-60.
de Menezes EW, Lima EC, Royer B, de Souza FE, dos Santos BD, Gregório JR, et al. Ionic silica based hybrid material containing the pyridinium group used as an adsorbent for textile dye. J.Colloid . Interf Sci. 2012;378: 10–20
Jaseetha AS , Nillanjana D. Biosorptive Removal of Lindane Using Pretreated Dried Yeast Cintractia Sorghi Vitjzn02– Equilibrium and Kinetic Studies. IJ PP S.2013; 5(3): 987-993.
Korsmeyer RW, Peppas NA. Effect of the Morphology of HydrophilicPolymeric Matrices on the Diffusion and Release of Water-Soluble Drugs. J. Membrane Sci. 1981; 9(3): 211-227.
Kopcha M, Lordi NG, Tojo KJ. Evaluation of release from selected thermosoftening vehicles. J. Pharm. Pharmacol. 1991; 43:382.
Costa PJ, Lobo S. Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci. 2001; 13(2): 123-133.