Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions

Main Article Content

Sahar S. Hassan
Nidhal M. Hassan
Shaymaa Rajab Baqer
Asmaa M. saleh

Abstract

               In this paper, the complexes of Shiff base of Methyl -6-[2-(diphenylmethylene)amino)-2-(4-hydroxyphenyl)acetamido]-2,2-dimethyl-5-oxo-1-thia-4-azabicyclo[3.2.0]heptane-3-carboxylate (L) with Cobalt(II), Nickel(II), Cupper(II) and Zinc(II) have been prepared. The compounds have been characterized by different means such as FT-IR, UV-Vis, magnetic moment, elemental microanalyses (C.H.N), atomic absorption, and molar conductance. It is obvious when looking at the spectral study that the overall complexes obtained as monomeric structure as well as the metals center moieties are two-coordinated with octahedral geometry excepting Co complexes that existed as a tetrahedral geometry. Hyper Chem-8.0.7 program was employed, after calculating the heat of formation (ΔH°f), binding energy (ΔEb), dipole moment( µ ), and FT-IR frequencies are carried out in gas phase, the geometric shape is suggested. The compounds have been also screened for their bioactivity to antibacterial and antifungal.


 

Downloads

Download data is not yet available.

Article Details

How to Cite
1.
Hassan SS, Hassan NM, Baqer SR, saleh AM. Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions . Baghdad Sci.J [Internet]. [cited 2021May9];18(4):1269. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/4802
Section
article

References

Jisha M J. Synthesis and characterization of Schiff base complexes of Cu (II), Ni (II), Co (II) complexes of Schiff base derived from furan 3-carboxaldehyde and 3-amino pyridine. IJSR. 2017; 7: 10-19.‏

Shaygan S, Pasdar H, Foroughifar N, Davallo M , Motiee F. Cobalt (II) Complexes with Schiff Base Ligands Derived from Terephthalaldehyde and ortho-Substituted Anilines: Synthesis, Characterization and Antibacterial Activity. Appl. Sci. J. 2018; 8(3): 385.‏

Babamale H F, Lawal A, Rajee O A , Oloyede E A. Synthesis, characterization and biological activity studies of mixed paracetamol-ascorbic acid metal complexes. JASEM. 2016; 20(4): 1157-1161.‏

Abd-Elzaher M M, Labib A A, Mousa H A, Moustafa S A, Ali M M , El-Rashedy A A. Synthesis, anticancer activity and molecular docking study of Schiff base complexes containing thiazole moiety. BJBAS.2016; 5(1): 85-96.‏

Zhu S, Xu S, Jing W, Zhao Z, Jiang J. Synthesis and herbicidal activities of p-menth-3-en-1-amine and its Schiff base derivatives. J Agr food chem. 2016; 64(51): 9702-9707.‏

Beg S, Nayak A K, Kohli K, Swain S , Hasnain M S. Antimicrobial activity assessment of time-dependent release bilayer tablets of amoxicillin trihydrate. Braz. J. of Pharm. Sci. 2012; 48(2): 265-272.‏

Anacona J R, Mago K , Camus J. Antibacterial activity of transition metal complexes with a tridentate NNO amoxicillin derived Schiff base. Synthesis and characterization. App.Organomet. Chem. 2018; 32(7): e4374.‏

Al-Mudhafar M M J. Synthesis, characterization and preliminary antibacterial evaluation of new Schiff bases of ampiciline and amoxicilline derived from istain drerivities. IGPPS. 2016; 8 (5): 113-116.

Hossain M S, Roy P K, Zakaria C M ,Kudrat-E-Zahan M. Selected Schiff base coordination complexes and their microbial application: A review. Int. J. Chem. Stud. 2018; 6: 19-31.‏

Khalida A T A. Modification and polymerization of some drugs by synthesis of β- lactam and oxadiazole cycles and study antibacterial activity with toxicity for some of them. PhD thesis, Baghdad University. 2015; 46.

Dalia M S A, Afsan F, Hossain M S, Mannan M A, Haque M M , Kudrat-E-Zahan M. Spectral and Thermal Characterization of Mn (II), Ni (II) and Zn (II) Complexes Containing Schiff Base Ligands Towards Potential Biological Application. Asian J. Chem.Sci. 2018;4(4): 1-11.‏

Alias M, Bakir SR. Synthesis, Spectroscopic Characterization and in Vitro Cytotoxicity Assay of Mropholine Mannich Base Derivatives of Benzimidazole with Some Heavy Metals. ANJS. 2018; 21(3):50-60.‏

Bakir S R , Alias M. Synthesis, Characterization And Computational Studies Of Mannich Base Ligands And Their Metal Complexes Vo (II), Co (II), Ni (II) And Cu (II). Res. J. of Phram., Bio.Chem.Sci. 2018; 9(5): 877-890.‏

Bakir SR. Synthesis, Spectral Studies, and Theoretical Treatment of some New Metal Complexes with Tridentate Ligand (Schiff and Mannich Base). Baghdad Sci. J. 2016; 13(2): 340-351.‏

Figgis B N , Hitchman M A. Ligand field theory and its applications .New York: Wiley-Vch . 2000; 158.

Liaqat M , Mahmud T, Imran M, Ashraf M, Haq A U, Muddassar M, et al . Synthesis, characterization and biological activities of a novel Mannich base 2-[(3, 4-dimethoxyphenyl) (pyrrolidin-1-yl) methyl] cyclopentanone and its complexes with Cu (II), Co (II), Ni (II) and Fe (II) ions. Bulg. Chem. Commun.. 2018; 50(1), 37-43.‏

Abdulkarem A A. Synthesis and Antibacterial Studies of Metal Complexes of Cu (II), Ni (II) and Co (II) with Tetradentate Ligand. J. Biophys. Chem. 2017; 8(02): 13-21.‏

Ejidike I , Ajibade P. Synthesis, characterization and biological studies of metal (II) complexes of (3E)-3-[(2-{(E)-[1-(2, 4-dihydroxyphenyl) ethylidene] amino} ethyl) imino]-1-phenylbutan-1-one Schiff base. Molecules. 2015; 20(6): 9788-9802.‏

Shaker S A, Khaledi H, Cheah S C , Ali H M. New Mn (II), Ni (II), Cd (II), Pb (II) complexes with 2-methylbenzimidazole and other ligands. Synthesis, spectroscopic characterization, crystal structure, magnetic susceptibility and biological activity studies. Arab. J. of Chem. 2016; 9: S1943-S1950.‏