Spectrophotometric and Spectrofluorimetric Determination of Terazosin in Tablets by Eosin Y

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Zeena Z. Al abdali
Maysam H. Al Fakri

Abstract

Simple, sensitive and accurate two methods were described for the determination of terazosin. The spectrophotometric method (A) is based on measuring the spectral absorption of the ion-pair complex formed between terazosin with eosin Y in the acetate buffer medium pH 3 at 545 nm. Method (B) is based on the quantitative quenching effect of terazosin on the native fluorescence of Eosin Y at the pH 3. The quenching of the fluorescence of Eosin Y was measured at 556 nm after excitation at 345 nm. The two methods obeyed Beer’s law over the concentration ranges of 0.1-8 and 0.05-7 µg/mL for method A and B respectively. Both methods succeeded in the determination of terazosin in its tablets

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Al abdali ZZ, Al Fakri MH. Spectrophotometric and Spectrofluorimetric Determination of Terazosin in Tablets by Eosin Y. Baghdad Sci.J [Internet]. 2021Mar.30 [cited 2021Apr.13];18(1(Suppl.):0775. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/4870
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