Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients

Main Article Content

Firas Faris Rija
Sura Zahim Hussein
Mohammad Ahmad Abdalla

Abstract

            Rheumatoid arthritis (RA) is a systematic autoimmune disorder with chronic inflammation changes of unknown etiology. Various synovial inflammatory and proliferative alterations may contribute to the cartilaginous tissues and invasive bony tissues, leading to destructive joints and malformed bones. This disease is mostly due to infective microorganisms or genetic susceptibility causing immune system disturbances through triggering both T-cells and B-cells. Furthermore, different immune cells may secret cytokines, which are responsible for some RA pathogenesis activity. From ninety individuals, serum sample was collected; thirty of them were normal and sixty cases were patients with RA attended a privet medical clinic at Tikrit city from May 2019 to November 2019. Age, in both patients and control groups, ranged between (18-50) years, they had assay of Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-10 (IL-10), Tumor necrosis factor (TNF)-α, Leptin, Adiponectin, and C-reactive protein. The present study shows that (IL-1, Leptin, and CRP) levels were higher in Rheumatoid Arthritis patients than control, while (IL-6, IL-10, TNFα, and ADP) levels were lower; therefore, cytokines can play an essential role in RA pathogenesis. The current study may bring attention to adiponectin and leptin for their roles in the pathogenesis of RA. Special consideration was devoted to those proteins, which act on cells associated with RA, also for possible usage of these protein levels as potential biomarkers for the disease activity and therapeutic response.

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1.
Rija FF, Hussein SZ, Abdalla MA. Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients. Baghdad Sci.J [Internet]. [cited 2021Jan.20];18(2):0247. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5362
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article
Author Biography

Mohammad Ahmad Abdalla, Tikrit University College of Medicine

 الاستاذ الدكتور محمد أحمد عبدالله

كلية الطب - جامعة تكريت

فرع التشريح والأنسجة

Professor Dr.Mohammad Ahmad Abdalla

Tikrit University College of Medicine

Department of Anatomy and Histology

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