Synthesizing, Structuring, and Characterizing Bioactivities of .Cr(III), La(III), and Ce(III) .Complexes with Nitrogen, Oxygen .and Sulpher donor bidentate Schiff base ligands

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Anaam M. Rasheed
Sinan M. M. Al-Bayati
Dr.Rehab A.M. Al-Hasani
Muna Ali Shakir

Abstract

Two Schiff bases, namely, 3-(benzylidene amino) -2-thioxo-6-methyl 2,5-dihydropyrimidine-4(3H)-one (LS])and 3-(benzylidene amino)-6-methyl pyrimidine 4(3H, 5H)-dione(LA)as chelating ligands), were used to prepare some complexes of Cr(III), La(III), and Ce(III)] ions. Standard physico-chemical procedures including metal analysis M%, element microanalysis (C.H.N.S) , magnetic susceptibility, conductometric measurements, FT-IR and UV-visible Spectra were used to identify Metal (III) complexes and  Schiff bases (LS) and (LA). According to findings, a [Cr(III) complex] showed six coordinated octahedral geometry, while [La(III), and Ce(III) complexes]were structured with coordination number seven.  Schiff's bases and mineral complexes were examined in vitro to investigate potential inhibition against Gram-positive bacteria such as Pseudonomous aerugionosa and Gram-negative bacteria such as Staphylococcus aureus. The low concentration for inhibition has been also determined by studying the minimal inhibitory concentrations MIC .Antibiotics (Ampicillin, Amoxicillin) have been chosen to contrast their activity. Furthermore, Anti-fungal activity against two types of fungi ʺAspergillus flavusʺ and ʺPenicillum Spp.ʺ was studied for these compounds. The results of the antibacterial activity were better compared to the standard drugs.

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Rasheed AM, Al-Bayati SMM, Al-Hasani DA, Shakir MA. Synthesizing, Structuring, and Characterizing Bioactivities of .Cr(III), La(III), and Ce(III) .Complexes with Nitrogen, Oxygen .and Sulpher donor bidentate Schiff base ligands. Baghdad Sci.J [Internet]. 2021Dec.20 [cited 2022Jan.20];18(4(Suppl.):1545. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5618
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References

Hamil AM, El-ajaily MM, Abdelkarem M, Boghdadi HA, Himmet H, Dugas Penney C. Synthesis, spectroscopic investigation and antibacterial of some new Schiff base chelates. Int J Chem Anal. 2014; 6(1): 55-623.

Amer S, El-Wa kiel N, El-Ghamry H. Synthesis, spectral, antitumor and antimicrobial studies on Cu(II) complexes of purine and triazole Schiff base derivatives. J Mol Struct. 2013; 1049: 326-335.

Md. Saddam Hossain, Pijush Kanti Roy, CM Zakaria and Md. Kudrat-EZahan. Selected Schiff base coordination complexes and their microbial application: A review.International J. Chem. Stud. 2018; 6(1): 19-31.

Sathe BS, Jaychandran E, Jagtap VA, Sreenivasa GM. Synthesis characterization and anti-inflammatory evaluation of new fluorobenzothiazole schiff ’s bases. Inte. J Pharm. Research and Devel. 2011; 3(3):164-169.

Saranya A, Sundaramurthy Santha Lakshmi. In vitro antioxidant, antimicrobial and larvicidal studies of schiff base transition metal complexes. J Chem Pharm Res. 2015; 7(4): 180-186.

Rehab A. M. Al-Hassani,Anaam M.R., Sinan M.M.Synthesis. Characterization and Study the Biological Activity of Some Pyridine Derivatives and their Coordination Complexes with Some Transition Metal Ions.Third women conference entitled (Women and Science in Iraq),Baghdad Sci.J. December 2016; 361-376.

Khalil A., SinanM.Al-Bayati, AnaamR.. Synthesis,Characterization, Thermal study and Bio -logical Evaluation of transition metal complexes supported by ONNNO-pentadentate Schiff Base ligand. American Journal of Chemistry. 2016; 6(1),1-7.

Abid K.K., Al-Bayati R.H. ,Faeq H.A.A. American Journal of Chemistry. 6.2016; 29.

Katarzyna and B., Elżbieta L.,Schiff bases – interesting range of applications in various fields of science.CHEMIK 2014;(68) 2: 129–134.

Moksharagni B., Reddy KH. Synthesis, spectral characterization and DNA binding properties of lanthanide(III) complexes with 2-formylpyridine nicotinoylhydrazone. Int J Pharm Sci Res 2017; 8(8): 3379-84.

Juan-David Londoño-Mosquera, Alberto Aragón-Muriel, Dorian Polo-Cerón. Synthesis, antibacterial activity and DNA interactions of lanthanide(III) complexes of N(4)-substituted thiosemicarbazones. Univ. Sci. 23 (2): 141-169, 2018.

Shkya P.R., Singh A.K.,Rao T.R. Synth React Inorg Metal-Orga Nano-Metal Chem.,44,P739 Ranajit K.R., Electronic Spectra of Transition Metal Complexes.1st Ed.,NCBA Publishing, India-New Delhi.2012.

Ranajit K.R., Electronic Spectra of Transition Metal Complexes. 1st Ed. NCBA Publishing. India-New Delhi. 2012.

Shahbazy M, Pakravan P, Kompany-Zareh M. Multivariate, spectrochemical analysis of interactions of three common Isatin derivatives to calf thymus DNA in vitro, Journal of Biomolecular Structure and Dynamics.35.2017;2539-2556.

Rehab A. M. Al-Hassani. Synthesis, Structural, Antimicrobial activities and Theoretical Studies of Some New Trivalent Metal Complexes with Thiocarbamide Derivative. Int. J. of ChemTech Res. 2016;9(5): 723-737.

Sinan M.Al-Bayati, AnaamR.,Enas Zuhair,Khalil Abid ,Wessal Khamis. Synthesis and Spectroscopic Studies of New Alkoxy Schiff Base Complexes Based on Coumarin moiety. American Journal of Chemistry.2018:8(1):1-7.

Geethalaksmi V., Theivarasu C. Synthesis and Characterization of Samarium(III) and Gadolinium(III) Complexes Containing2-Methoxy-6-((2-(Piperazin-1yl)Ethylimino)Methyl) Phenol as Ligand, Int. J. of ChemTech Res. 2016;9(5): 941-949.

Effat I., Navabeh N., Fatemeh N.,Elham B., Bernhard N. Synthesis and Structures of Two Lanthanide Complexes Containing a Mixed Ligand System: [Ln(Phen)2(L)3(HL)]•H2O [Ln = La, Ce; Phen = Phenanthroline; HL = Salicylic Acid], Bull. Korean Chem. Soc.,2013; (11) 34.

- Ana-Madalin Maciuca, Alexandra-Cristina Muntearu, Valentian Uivarosi.Quinolone Complexes . With Lathanid Ions : An Insight into their Analytical Application and Biological Activity. Molecules,2020; (25):1347.

Meihaus, K.R., Minasian, S.G.,Lukens, W.W., Kozimor S.A., Shuh, D.K., Tyliszczak, T.,and Long, J.R. Influence of pyrazolate vs. N-heterocyclic carbene ligands on the slow magnetic relaxation of homoleptic trischelate lanthanide(III) and uranium(III) complexes. J. Am. Chem. Soc. 2014; 136: 6056–6068.

Fabrice P., Saskia S., , Bertrand L., , François R., , Stéphane G., Boris Le G., , Olivier C., , Olivier M., Lahcène O. Magnetic and Photo-Physical Properties of Lanthanide Dinuclear Complexes Involving the 4,5-Bis(2-Pyridyl-N-Oxidemethylthio)-4′,5′-Dicarboxylic Acid-Tetra thia fulvalene-, Dimethyl Ester Ligand. Inorganics. 2015(3): 554-572.