Serum prolactin, Preptin, CCL 18 and genetic polymorphisms in Iraqi women with polycystic ovary syndrome
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Abstract
The polycystic ovary syndrome is an endocrine condition. One of the leading causes of female infertility and the most common disorder among women. The work was being carried out on 100 Iraqi women (50 cases confirmed with PCOS and 50 controls). Between October 2019 and March 2020, blood samples were collected from the Advanced Institute of Infertility Diagnosis and Assisted Reproductive Technology at AL-Nahrain University and a private laboratory. ELISA was used to evaluate the biochemical parameters of preptin, FSH, insulin, LH, and CCL 18 in serum samples from the AFIAS-6 (AFIAS Automated Immunoassay System). The findings of the analysis indicate that, as opposed to the control group, values of prolactin (ng/ml), LH (mIU/ml), Preptin (pg/ml) and CCL 18 (ng/ml) Quite higher in PCOS sickness (p < 0.001) Compared with the patient group, the values of testosterone (ng/ml) and FSH (mIU/ml) was noticeably higher (p <0.05), and PRLR gene expression levels in PCOS patients were significantly increased by 3.6 times. I n summary, the levels of Preptin and CCL18 can be regarded as PCOS markers.
Received 8/3/2021
Accepted 23/6/2021
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References
Michelmore KF, Balen AH, Dunger DB, Vessey MP. Polycystic ovaries and associated clinical and biochemical features in young women. Clin Endocrinol. 1999 Dec; 51(6):779-86.
Gharani N, Waterworth DM, Batty S, White D, Gilling-Smith C, Conway GS, McCarthy M, Franks S, Williamson R. Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism. Hum Mol Gene. 1997 Mar 1; 6(3):397-402.
Coutinho EA, Kauffman AS. The role of the brain in the pathogenesis and physiology of polycystic ovary syndrome (PCOS). Med sci. 2019 Aug; 7(8):84.
Hieshima K, Imai T, Baba M, Shoudai K, Ishizuka K, Nakagawa T, et al. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. J Immulo. 1997 Aug 1; 159(3):1140-9.
Adema GJ, Hartgers F, Verstraten R, de Vries E, Marland G, Menon S, et al . A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells. Nature. 1997 Jun; 387(6634):713-7.
Bu Z, Kuok K, Meng J, Wang R, Xu B, Zhang H. The relationship between polycystic ovary syndrome, glucose tolerance status and serum preptin level. Reprod Biol Endocrinol. 2012 Dec 1; 10(1):10.
Yang G, Li L, Chen W, Liu H, Boden G, Li K. Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Ann Med. 2009 Jan 1; 41(1):52-6.
Daimon M, Kamba A, Murakami H, Mizushiri S, Osonoi S, Yamaichi M, etal. Association between serum prolactin levels and insulin resistance in non-diabetic men. PLoS One. 2017 Apr 6;12(4):e0175204.
Gorvin CM. The prolactin receptor: diverse and emerging roles in pathophysiology. J Clin Trans Endocrinol. 2015 Sep 1;2(3):85-91.
Yang H, Di J, Pan J, Yu R, Teng Y, Cai Z, etal. The Association Between Prolactin and Metabolic Parameters in PCOS Women: A Retrospective Analysis. Front Endocrinol. 2020 May 12; 11:263.
Malini NA, George KR. Evaluation of different ranges of LH: FSH ratios in polycystic ovarian syndrome (PCOS)–Clinical based case control study. Gen Comp Endocrinol. 2018 May 1; 260:51-7.
Nath CK, Barman B, Das A, Rajkhowa P, Baruah P, Baruah M, etal. Prolactin and thyroid stimulating hormone affecting the pattern of LH/FSH secretion in patients with polycystic ovary syndrome: A hospital-based study from North East India. J Famil Med Prim Car. 2019 Jan; 8(1):256.
Mutib MT, Hamdan FB, Al-Salihi AR. Anthropometric, hormonal and biochemical indices in patients with polycystic ovarian syndrome. IJEIR .2013; 3(6):20-6.
Fakhoury H, Tamim H, Ferwana M, Siddiqui IA, Adham M, Tamimi W. Age and BMI adjusted comparison of reproductive hormones in PCOS. J Fami Med Prim Car. 2012 Jul; 1(2):132.
Wu XQ, Xu SM, Liu JF, Bi XY, Wu YX, Liu J. Association between FSHR polymorphisms and polycystic ovary syndrome among Chinese women in north China. J Asst Reprod Genet. 2014 Mar 1; 31(3):371-7.
Naykı Ü, Koç A, Naykı C, Kaya ÖÖ, Kulhan M, Günay M. A Single Nucleotide Polymorphism of Follicle-Stimulating Hormone Receptor Gene in Turkish Women With Polycystic Ovary Syndrome: A Cross-Sectional Study. J Clin Experi Inves. 2016; 8(2):39-44.
Celik O, Celik N, Hascalik S, Sahin I, Aydin S, Ozerol E. An appraisal of serum preptin levels in PCOS. Fertil Steril. 2011 Jan 1; 95(1):314-6.
Sam JE, Suryanarayana KM, Dharmalingam M, Kalra P, Selvan C. Serum CCL 18 levels in women with polycystic ovarian syndrome. India J Endocrinol Metab. 2020 May; 24(3):280.
Ajmal N, Khan SZ, Shaikh R. Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article. Eur J Obste Gynecol Reprod Biol: X. 2019 Jul 1; 3:100060.
Torres PJ, Skarra DV, Ho BS, Sau L, Anvar AR, Kelley ST, et al. Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice. BMC Microbiol. 2019 Dec; 19(1):1-5.
Paulson M, Norstedt G, Sahlin L, Hirschberg AL. Association between prolactin receptor expression and proliferation in the endometrium of obese women with polycystic ovary syndrome. Gynecol Endocrinol. 2020 Mar 3; 36(3):226-32.
Franik G, Madej P, Guz-Lem M, Owczarek A, Chudek J, Olszanecka-Glinianowicz M. Daytime decrease of prolactin levels is associated with PCOS regardless to nutritional status and other hormones levels. Gynecol Endocrinol. 2017 May 4; 33(5):336-41.