Preparation, Spectroscopy, Biological Activities and Thermodynamic Studies of New Complexes of Some Metal Ions with 2-[5-(2-Hydroxy-Phenyl)- 1,3,4-Thiadiazol-2-Ylimino]-Methyl-Naphthalen-1-Ol]
Main Article Content
This study describes the preparation of new series of tetra-dentate N2O2 dinuclear complexes (Cr3+, Co2+, Cu2+) of the Schiff base derived from condensation of 1-Hydroxy-naphthalene-2-carbaldehyde with 2-amino-5-(2-hydroxy-phenyl)-1,3,4-thiadiazole. The structures of the ligands were identified using IR, UV-Vis , mass, elemental analysis and 1H-NMR techniques. All prepared complexes have been characterized by conductance measurement, magnetic susceptibility, electronic spectra, infrared spectrum, theromgravimatric analysis (TGA) and metal analysis by atomic absorption. From stoichiometry of metal to ligand and all measurements show a octahedral geometry proposed for all complexes of the (Cr3+, Co2+, Cu2+). conductivity measurement shows that of the prepared (Co2+, Cu2+) complexes were non electrolyte but (Cr3+) complexes were electrolyte. The parameters of thermodynamic, activation energy Ea , enthalpy ΔH, entropy ΔS and Gibbs free energy ΔG were calculated using Coats-Redfern method by the TGA curve. The bioactivity of the prepared (LH2) and its complexes have been examined with antibacterial activity which shows significant activity against some fungi and bacteria.
Published Online First 20/1/2022
This work is licensed under a Creative Commons Attribution 4.0 International License.
Thomas R, Roger K, Sebastian F, Juliane M, Peter K, Michael P, et al. Systematic comparison of the structure of homoleptic tetradentate N2O2-type Schiff base complexes of tetravalent f-elements (M(IV) = Ce, Th, U, Np, and Pu) in solid state and in solution. Dalton Trans.2019;48: 11217-11234.
Barwiolek M, Kędziera A K, Muziol T M, Jankowska D, Jezierska J, Bieńko A. Dinuclear Copper(II) Complexes with Schiff Bases Derived from 2-Hydroxy-5-Methylisophthalaldehyde and Histamine or 2-(2-Aminoethyl)pyridine and Their Application as Magnetic and Fluorescent Materials in Thin Film Deposition. Int J Mol Sci. 2020; 21(13): 4587
Maher K. Schiff Bases Derived from 2-Hydroxynaphthalene-1-carbaldehyde and their Metal Complexes. Asian J Chem. 2018; 30 (6):1171-1182.
Hanan AA, Sami AZ, New Schiff bases of 2-(quinolin-8-yloxy) acetohydrazide and their Cu(II), and Zn(II) metal complexes: their in vitro antimicrobial potentials and in silico physicochemical and pharmacokinetics properties. Open Chem. 2010; 18: 591–607
Ghaedi M, Niknam K, Soylak M, Cloud Point Extraction and Flame Atomic Absorption Spectrometric Determination of Lead, Cadmium and Palladium in Some Food and Biological Samples. Pak. J Anal Environ Chem. 2011, 12(2):42-48.
Aeed S A, Al-Sorchee SM, Suhab E S, Marwan M S. Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacterial biological study. Egypt J Chem. 2021; 64( 6 ): 2879 – 2888
Suleman VT, Al-Hamdani AAS, Ahmed SD, Phosphorus Schiff base ligand and its complexes: Experimental and theoretical investigations. Appl Organomet Chem. 2020; 10(1):1-16
Al Zoubi W, Al-Hamdani AAS, Widiantara I P, Hamoodah R G, Ko Y G. Theoretical studies and antibacterial activity for Schiff base complexes. J Phy Org Chem. 2017; 30(12):37-45
Shaalan N, Abed AY, Alkubaisi HM, Mahde M, Synthesis, Spectroscopy, Biological Activities and Thermodynamic Studies for New Complexes of Some Lanthanide Metals with Schiff's Bases derived from [2-acetylthiophene] with [2,5-dihydrazino-1,3,4-thiadiazole]. Res J Chem Environ. 2019; 23:181-187.
Al-Hamdani AAS, Shaalan N, Hassan S.S, Hasan Z.A.A, Preparation and Spectroscopic Studies of Some Metal Ion Complexes of 2-((4-Formyl-3-Hydroxynaphthalen-2-yl) Diazenyl) Benzoic Acid, Baghdad J Sci : 2nd National Conference of Chemistry;2016; 3(2s):95-104
Ismael M, Hmood AB, Shaalan N, Study on Optical Properties of PVC-2,5di (2-Pyrrole hydrazone) 1,3,4-thiadiazole Complexes. Res J Pharm Biol Chem Sci. 2016; 7(5)2347-2355
Akram E, Shaalan N, Rashad, Study of structural and optical properties of New Films Derived PVC-2-[5-phenyl-1,3,4-thiadiazol-2-ylimino-methyl]-benzoic acid. Res J Pharm Biol Chem. Sci. 2016; 7(5)2836-2844
Hasnia R, Tayeb B, Mohamed H Y, Hocine I. Study on the Cloud Point Extraction of Copper(II) from an Aqueous Sulfate Medium with N, N′-Bis(salicylideneaminoethyl)amine Polydentate Schiff Base intoa Nonionic Surfactant Phase. J Chem Eng Data. 2010; 55: 912-918.
AlZoubi W, Kim MJ, Al‐Hamdani AAS, Kim YG, Ko Y, G.Phosphorus‐based Schiff bases and their complexes as nontoxic antioxidants: Structure–activity relationship and mechanism of action. Appl Organo Chem.2019; 33:11-16.
Lumanyano LAN, Karel GVE, spectrophotometry mole ratio and continuous Variation experiments with dithizone . Afr J Chem Educ. 2017; 7(2) :59-92
Turan N, Sekerci M. Metal Complexes of Schiff Base Derived from Terephthalaldehyde and 2-Amino-5-Ethyl-1,3,4-ThiadiazoleSynthesis, Spectral and Thermal Characterization. Synth Reac Inorg Met Org Chem..2009; 39:651–657.
Sobola AO, Watkins GM, Brecht BV, Synthesis characterization and antimicrobial activity of copper(ii) complexes of some ortho-substituted aniline schiff bases; crystal structure of bis(2-methoxy-6-imino)methylphenol copper(ii) complex. S Afr J Chem.2014; 67:45–51
Boghaei D M, Lashanizadegan M. Synth React Inorg Met Org Chem.2010;30:1393-1404.
Shaalan N, Hassan SS, Al-Hamdani A A S, Synthesis, Spectroscopic and Thermodynamic Studies of Metal Complexes with Schiff Bases Derived from 2-[5-(Pyridin-2-Ylmethylene)-amino] 1,3,4-Oxadiazol-2-yl-Phenol. JNUS. 2015;18 (4): 13-21.
Srivastava AK, Pandey OP, Sengupta SK, Synthesis, Spectral and Antimicrobial Studies of Bis(cyclopentadienyl)titanium(IV) Derivatives with Schiff Bases Derived from 2-Amino-5-phenyl-l,3,4-thiadiazole. Bio Chem Appl. 2005; 3: 3-4
Shaalan N, Fadel Z H, Mahmood W A, Al-Hamdani A A S, Synthesis and characterization Studies of Metal Complexes with Schiff base derived from 4-[5-(2-hydoxy-phenyl)-[1,3,4-oxadiazol-2-ylimino methyl]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one. Baghdad J Sci : 2nd National Conference of Chemistry;2016; 3(2s):19-28.
AL-Mukhtar S E, Mustafa I A. Inorganic and Coordination Chemistry.1st ed Arabic Version, University of Mosul.1988,611p
Fan X, Zhang G, Zhu C, Synthesis of 2-[2-(5-Methylbenzoth -iazolyl)azo]-5-dimethylamino benzoic Acid and its Application to the Spectrophotometric Determination of Nickel. Analyst .1988; 123 :109-112.
Nicholls D. The Chemistry of Iron, Cobalt and Nickel. Pergamon press, Oxford,1st ed.1973:1037-1154.
Al-Hamdani A A S, AlKafaje N R, Shaalan N, Preparation, Spectral, Thermal and Bio Activity Studies of Azo Dyes Complexes. Res J Pharm Biol Chem Sci, 2017;8(3): 740-750.
Obaid S M H, Jarad AJ, Al-Hamdani AAS. Synthesis, Characterization and Biological Activity of Mixed Ligand Metal Salts Complexes with Various Ligands. J Phys: Conf Ser;1st international Conference on pure Series 2020; 1660:1-13
Al-Hamdani A A S, Al-dulyme N K G, Synthesis, Spectroscopic and Theoretical Studies of Some New Transition Metal Complexes with Mixed ligands Schiff Base and Bipyridyl, Ibn AL-Haitham J Pure Appl Sci . 2017;30 (2): 69-83.