DC-SIGN Receptor Level in Rheumatoid Arthritis Patients in Baghdad; Serological study
DOI:
https://doi.org/10.21123/bsj.2022.6559Keywords:
Autoimmunity, CD209, COVID-19, DC-SIGN, Rheumatoid arthritisAbstract
Rheumatoid arthritis (RA), is an autoimmune, and inflammatory disease that is closely related to the destruction of cartilage and bone. DC-SIGN are important types of C-type lectin receptors (CLRs), expressed on dendritic cells and macrophages, and have a central role in regulating innate and adaptive immunity, function as pattern recognition receptors, and as cell adhesion molecules. Recent evidence has demonstrated that DC-SIGN is involved in the pathophysiological of chronic inflammation, so DC-SIGN has been linked to several autoimmune and may play an essential indicator in the pathogenesis and progression of RA. Therefore, the purpose of this study is to determine the serum level of DC-SIGN in RA patients, as well as the level of DC-SIGN based on demographic characteristics. Fifty Iraqi RA patients were enrolled in the study, and a control sample of 38 healthy individuals (ascertain by laboratory and clinical tests) were included and matched by gender, age, and ethnicity with the patients. The DC-SIGN concentration was calculated in the patients’ serum and compared to control using the ELISA assay and the results revealed significantly increased serum level of DC-SIGN (12.047 ± 1.114 vs. 6.863 ± 0.806 ng/ml) was recorded in RA patients compared to controls. When correlating results, it was shown that the concentration of DC-SIGN in the serum did not record a significant difference between gender and age, as well as the blood groups. To determine the impact of the therapeutic status in RA patients on the DC-SIGN level, it was found that the concentration of DC-SIGN level was higher in untreated patients compared to treated patients. Regarding viral infection, when an investigation was conducted in RA patients infected with SARS-CoV-2, the serum level of DC-SIGN in RA patients with COVID-19 showed no change in concentrations compared to uninfected RA patients.
Received 18/9/2021
Accepted 28/11/2021
Published Online First 20/5/2022
References
Ridgley LA, Anderson AE, Pratt AG. What are the dominant cytokines in early rheumatoid arthritis? Curr Opin Rheumatol. 2018 Mar; 30(2): 207-214. doi: 10.1097/BOR.0000000000000470 . PMID: 29206659; PMCID: PMC5805125.
Ad’hiah A H, Mahmood AS, Al-Kazaz AA, Mayouf KK. Gene Expression and Polymorphism of Interleukin-4 in a Sample of Iraqi Rheumatoid Arthritis Patients. Baghdad Sci. J. 2018; 15(2): 130-137.http://dx.doi.org/10.21123/bsj.2018.15.2.0130
Mnich ME, van Dalen R, van Sorge NM. C-Type Lectin Receptors in Host Defense Against Bacterial Pathogens. Front Cell Infect Microbiol. 2020 Jul 7; 10:309. http://dx.doi.org/10.3389/fcimb.2020.00309 . PMID: 32733813; PMCID: PMC7358460.
Lindenwald DL, Lepenies B. C-Type Lectins in Veterinary Species: Recent Advancements and Applications. Int J Mol Sci. 2020 Jul 20; 21(14): 5122.http://dx.doi.org/10.3390/ijms21145122 . PMID: 32698416; PMCID: PMC7403975.
Yeo SG, Won YS, Kim SH, Park DC. Differences in C-type lectin receptors and their adaptor molecules in the peritoneal fluid of patients with endometriosis and gynecologic cancers. Int J Med Sci. 2018 Feb 12; 15(4): 411-416. http://dx.doi.org/10.7150/ijms.23360. PMID: 29511377; PMCID: PMC5835712.
Sprokholt JK, Heineke MH, Kaptein TM, van Hamme JL, Geijtenbeek TBH. DCs facilitate B cell responses against microbial DNA via DC-SIGN. PLoS One. 2017 Oct 4; 12(10): e0185580. http://dx.doi.org/10.1371/journal.pone.0185580 . PMID: 28976999; PMCID: PMC5627929.
Yang ZS, Huang SW, Wang WH, Lin CY, Wang CF, Urbina AN, et al. Identification of Important N-Linked Glycosylation Sites in the Hemagglutinin Protein and Their Functional Impact on DC-SIGN Mediated Avian Influenza H5N1 Infection. Int J Mol Sci. 2021 Jan 13; 22(2):743. https://doi.org/10.3390/ijms22020743. PMID: 33451024; PMCID: PMC7828482.
Choi B, Suh CH, Kim HA, Sayeed HM, Sohn S. The Correlation of CD206, CD209, and Disease Severity in Behçet's Disease with Arthritis. Mediators Inflamm. 2017; 2017:7539529. http://dx.doi.org/10.1155/2017/7539529 . Epub 2017 Mar 9. PMID: 28377641; PMCID: PMC5362722.
Chan HC, Wang SC, Lin CH, Lin YZ, Li RN, Yen JH. A novel CD209 polymorphism is associated with rheumatoid arthritis patients in Taiwan. J Clin Lab Anal. 2021 May; 35(5): e23751. https://doi.org/10.1002/jcla.23751 . Epub 2021 Apr 1. PMID: 33792986; PMCID: PMC8128313.
Kilimozhi D, Parthasarathy V, Upendar K. Arthritis- a review of clinical features, differential diagnosis and treatments. Int J Pharm Technol. 2010; (2)1: 1-40. Available Online through Review Article www. ijptonline. com
Al-Sadoun MB, AL-Sabaawy OM. Disorder Activity of Some Enzymes Plays an Important Role in Pathological Mechanism of Rheumatoid Arthritis Disease. Baghdad Sci. J. 2015; 12(3): 572-581.
Verthelyi D. Sex hormones as immunomodulators in health and disease. Int Immunopharmacol. 2001 Jun; 1(6): 983-93. https://doi.org/10.1016/s1567-5769(01)00044-3 . PMID: 11407317.
Cunningham M, Gilkeson G. Estrogen receptors in immunity and autoimmunity. Clin Rev Allergy Immunol. 2011 Feb; 40(1): 66-73. https://doi.org/10.1007/s12016-010-8203-5 . PMID: 20352526.
Kim DH, Park HJ, Park HS, Lee JU, Ko C, Gye MC, et al. Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity. Exp Mol Med. 2019 Apr 15; 51(4): 1-9. https://doi.org/10.1038/s12276-019-0237-z . PMID: 30988419; PMCID: PMC6465332.
Lasrado N, Jia T, Massilamany C, Franco R, Illes Z, Reddy J. Mechanisms of sex hormones in autoimmunity: focus on EAE. Biol Sex Differ. 2020 Sep 7; 11(1): 50. https://doi.org/10.1186/s13293-020-00325-4 . PMID: 32894183; PMCID: PMC7475723.
González DA, Díaz BB, Rodríguez Pérez Mdel C, Hernández AG, Chico BN, de León AC. Sex hormones and autoimmunity. Immunol Lett. 2010 Sep 6; 133(1): 6-13. http://dx.doi.org/10.1016/j.imlet.2010.07.001 . Epub 2010 Jul 14. PMID: 20637236.
Alubadi AE, Salih AM, Alkhamesi MB, Ali NJ. Gene frequencies of ABO and rhesus blood groups in Sabians (Mandaeans), Iraq. Baghdad Sci. J. 2014; 11(2): 1035-1042.
Salwa SA, Karim A. Distribution of Blood groups and Rhesus Factor among Selected Sample of Iraq Student. Iraqi J. Hematology. 2015; 4(2): 59-63.
Flegr J, Hoffmann R, Dammann M. Worse health status and higher incidence of health disorders in Rhesus negative subjects. PLoS One. 2015; 10(10): 1–14. http://dx.doi.org/10.1371/journal.pone.0141362
Bullock J, Rizvi SAA, Saleh AM, Ahmed SS, Do DP, Ansari RA, et al. Rheumatoid Arthritis: A Brief Overview of the Treatment. Med Princ Pract. 2018; 27(6): 501-507. http://dx.doi.org/10.1159/000493390. Epub 2018 Sep 2. PMID: 30173215; PMCID: PMC6422329.
Tang H, Lu X, Qie S, Xi J. Thoughts on detecting tissue distribution of potential COVID-19 receptors. Future Virol. 2020; 15(8): 489–96. http://dx.doi.org/10.2217/fvl-2020-0136 .
Mohammed HA, Alrawi AA, Ahmed ZA. Screening of mannose receptor (CD206) level in rheumatoid arthritis patients. Teikyo Med. J. 2021; 44(04): 1039- 1043. TMJ-11-08-2021-10575.
Zhu J, Wu C, Wu L. Associations Between Genetically Predicted Protein Levels and COVID-19 Severity. J Infect Dis. 2021 Jan 4; 223(1):19-22. https://doi.org/10.1093/infdis/jiaa660 . PMID: 33083826; PMCID: PMC7797748.
Ramos-Soriano J, Rojo J. Glycodendritic structures as DC-SIGN binders to inhibit viral infections. Chem Commun (Camb). 2021 May 25; 57(42): 5111-5126. https://doi.org/10.1039/D1CC01281A . Epub 2021 May 12. PMID: 33977972.
Cramer J, Aliu B, Jiang X, Sharpe T, Pang L, Hadorn A, et al. Poly-l-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses. ChemMedChem. 2021 Aug 5; 16(15): 2345-2353. https://doi.org/10.1002/cmdc.202100348 . Epub 2021 Jul 16. PMID: 34061468.
Alves I, Vicente MM, Gaifem J, Fernandes Â, Dias AM, Rodrigues CS, et al. SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis. J Immunol. 2021 Sep 15; 207(6): 1591-1598. http://dx.doi.org/10.4049/jimmunol.2100131 . Epub 2021 Aug 20. PMID: 34417260.
Massalska M, Maslinski W, Ciechomska M. Small Molecule Inhibitors in the Treatment of Rheumatoid Arthritis and Beyond: Latest Updates and Potential Strategy for Fighting COVID-19. Cells. 2020 Aug 11; 9(8): 1876. http://dx.doi.org/10.3390/cells9081876 . PMID: 32796683; PMCID: PMC7464410.
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