إرتباط محركات الخلية الالتهابية القوية بالمؤشرات الحيوية لتلف الحمض النووي المؤكسد في مرضى سرطان المعدة
DOI:
https://doi.org/10.21123/bsj.2022.6589الكلمات المفتاحية:
سرطان المعدة، السيتوكينات الالتهابية، الإجهاد التأكسدي، تلف الحمض النووي التأكسديالملخص
تحفز الإصابة بالبكتيريا الحلزونية سلسلة إشارات تؤدي إلى إنتاج السيتوكينات وتسبب الإجهاد التأكسدي، الذي يشارك في الاستجابة الالتهابية المزمنة التي تؤدي إلى الإصابة بسرطان المعدة. تنتج أنواع الأكسجين التفاعلية (ROS). 8-Hydroxydeoxyguanosine (8-OHdG) منتج متلف الحمض النووي المؤكسد المستمر. الغرض من الدراسة هو تقييم الارتباط بين مستويات السيتوكينات الالتهابية ووجود تلف الحمض النووي المؤكسد في مرضى المصابين بسرطان المعدة. بالإضافة إلى ذلك، تم إجراء تقييم للقيمة التشخيصية والإنذارية لتلف الحمض النووي المؤكسد والمؤشرات الحيوية السيتوكينية الالتهابية لسرطان المعدة. أجريت الدراسة على مرضى سرطان المعدة الذين تم تشخيصهم طبيا قبل اخذ العلاج. حيث تم اختيار 33 مريضا من المصابين بسرطان المعدة وتقسيمهم إلى المراحل الأولى والثانية والثالثة وفقا لعلم الأمراض السريرية، و32 فردا من الأشخاص الأصحاء المتطابقين مع العمر كمجموعة ضابطة. تم قياس مستوى كل من (8-OHdG)، السيتوكينات (IL-6، TNF-α،IFN-γ, CEA). أظهرت النتائج ارتفاعً بشكل ملحوظ (P<0.0001) في مستويات الدم كل من 8-OHdG وTNF-α وIFN-γ ارتفاعً بشكل غير ملحوظ (IL-6) (P=0.4747) في مرضى GC بالمقارنة بالمجموعة ضابطة، مع زيادة المستويات تدريجياً مع تقدم مراحل المرض. علاوة على ذلك، كان هناك ارتباط إيجابي ضئيل (P=0.3472) (r=0.12 بين مستويات 8-OHdG وIL-6، وارتباط إيجابي ملحوظ (P<0.0001) (r=0.7235) بين مستويات 8-OHdG, TNF-α, CEA,. في مرضى سرطان المعدة ومع ذلك، كان هناك ارتباط سلبي ضئيل (P= 0.6342) (r=-0.06559) بين مستويات 8-OHdG وIFN-γ. تظهر نتائج الدراسة الحالية وجود صلة قوية بين مستويات مصل 8-OHdG والسيتوكينات الالتهابية في مرضى GC. تشير الزيادة المعنوية في تلف الحمض النووي المؤكسد والمؤشرات الحيوية للسيتوكينات الالتهابي وCEA في الدم إلى أن الإجهاد التأكسدي والالتهاب المزمن متضمنان في تسرطن المعدة. تهدف هذه الملاحظات إلى أن 8-OHdG وTNF-α وIFN-γ هي مؤشرات حيوية قابلة للتطبيق لتشخيص ورم المعدة.
Received 30/9/2021
Accepted 9/1/2022
Published Online First 20/5/2022
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