Study the Quality of Nasopharyngeal plans Using Evaluation Indexes of IMRT and VMAT Treatment planning Techniques

Main Article Content

Ayat Methaq Khalaf
https://orcid.org/0000-0001-5333-2728
Basim Khalaf Rejah
https://orcid.org/0000-0003-0054-1184

Abstract

Radiation treatment has long been the conventional approach for treating nasopharyngeal cancer (NPC) tumors due to its anatomic features, biological characteristics, and radiosensitivity. The most common treatment for nasopharyngeal carcinoma is radiotherapy. This study aimed to assess the better quality of radiotherapy treatment techniques using intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT). The VMAT and IMRT are comparative techniques. Forty patients with nasopharyngeal carcinoma and forwarded for radiotherapy were treated with both advanced techniques, IMRT and VMAT, using eclipse software from Varian. The x-ray energy was set at 6 MV. The total prescribed dose was 70 Gy. The results show that the VMAT had better tumor coverage than the IMRT. Regarding quality indices, the IMRT shows a better dose homogeneity, while the VMAT gives better gradient and conformity indices. The best technique that reduces the dose to the right eye, optic chiasm, and thyroid is VMAT, while the esophagus and spinal cord are protected better with IMRT. The VMAT shows a special effect for IMRT for treating nasopharyngeal carcinoma.

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Khalaf AM, Rejah BK. Study the Quality of Nasopharyngeal plans Using Evaluation Indexes of IMRT and VMAT Treatment planning Techniques. Baghdad Sci.J [Internet]. 2024 Feb. 1 [cited 2024 Feb. 22];21(2):0437. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8124
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References

Pin T, Chen Z, Mei H, Rui Y, Xingchen P, Jianghong X Et al. Dual Attention-Based Dense SU-Net for Automatic Head-and-Neck Tumor Segmentation in MRI Images. Neurocomputing. 2021; 435(7): 103-113. https://doi.org/10.1016/j.neucom.2020.12.085 .

Nelson TCF, Wai M, Chun KS, Michael CHL, Wai T. Automatic Segmentation for Adaptive Planning in Nasopharyngeal Carcinoma IMRT Time Geometrical and Dosimetric Analysis. Med Dosim. 2020; 45(1): 60-65. https://doi.org/10.1016/j.meddos.2019.06.002 .

Erfan A, Pre-Diagnostic Dynamic HPV16 IgG Seropositivity and Risk of Oropharyngeal Cancer: Methodological Issues. Oral Oncol. 2018; 76: 83. https://doi.org/10.1016/j.oraloncology.2017.11.016.

Li Yanwei, HF, Wang X, Pan Z. Traditional Chinese Medicine Formula 01 for Nasopharyngeal Carcinoma (NPC01) for Head & Neck Cancer and Health-Related Quality of Life a Retrospective Study. BMC Complement. Med. Ther. 2022; 216(22): 1-7. https://doi.org/10.1186/s12906-022-03699-7 .

Saurav K, Vaishali M, Jayasri D S. Methanolic Neem Azadirachta Indica Stem Bark Extract Induces Cell Cycle Arrest, Apoptosis and Inhibits the Migration of Cervical Cancer Cells in Vitro. BMC complement Med Ther. 2022; 22(239): 1-16. https://doi.org/10.1186/s12906-022-03718-7 .

Yang K, Xie W, Zhang X, Wang Y, Shou A, Wang Q et al. A Nomogram for Predicting Late Radiation-Induced Xerostomia Among Locoregionally Advanced Nasopharyngeal Carcinoma in Intensity Modulated Radiation Therapy Era. Med Image Anal. 2021; 13(14): 18645–18657. https://www.aging-us.com/article/203308/pdf .

Guihua T, Haojiang L, Jiabin H, Chu H, Jiazhou C, Guangying R et al. A Sequential Method to Achieve Nasopharyngeal Carcinoma Segmentation Free from Background Dominance. Med Image Anal. 2022; 78(4): 203-216. https://doi.org/10.1016/j.media.2022.102381 .

Ian P, Fiorela MV, Pablo A. Calculation of Skin Dose Rate Conversion Factors Due to Surface Contamination from Frequently Used Radionuclides in Local Nuclear and Medical Facilities. J Med Phys. 2022; 47(3): 219-224. https://www.jmp.org.in/article.asp?issn=0971-6203 ; year=2022; volume=47; issue=3; spage= 219; epage=224; aulast= Pasquevich;type =0 .

Ehab M A, Shaimaa Sh, Rasha AE. The Dosimetric Comparison between Measured Tissue Maximum Ratio Directly by Water Phantom and That Calculated from Percentage Depth Dose Measurements in Small Field and Determined the Differences between Two Method Int J Manag Pract. 2021; 18(6): 384-388. https://ijmp.mums.ac.ir/article_16977_56b370c70dd027231fb32f55a9021b89.pdf .

Mohammad H, Pejman R, Martin AE, Andrew N, Catharine HA. Comparison of The Gamma Index Analysis in Various Commercial IMRT/VMAT QA Systems, Radiother Oncol. 2013, 109(3): 370-376. https://www.thegreenjournal.com/article/S0167-8140(13)00459-3/fulltext .

Madlool S, Abdullah S, Alabedi H, Alazawy N, Al-Musawi M, Saad D. Optimum Treatment Planning Technique Evaluation for Synchronous Bilateral Breast Cancer with Left Side Supraclavicular Lymph Nodes. Int J Manag Pract. 2021; 18(6): 414-420. https://ijmp.mums.ac.ir/article_16970_fc2329c897520b3af609982aeaec7a25.pdf .

Lachlan JM, Kathy R, Wei X, Biu C, John W, Lin L et al. Long-Term Late Toxicity, Quality of Life and Emotional Distress in Patients with Nasopharyngeal Carcinoma Treated with Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys. 2018; 102(2): 340–352. https://doi.org/10.1016/j.ijrobp.2018.05.060 .

Dai S, Jian JQ, Guo HF, Jun KS, Ye T, Liang X. Salivary Gland Function in Nasopharyngeal Carcinoma Before and Late After Intensity Modulated Radiotherapy Evaluated by Dynamic Diffusion-Weighted MR Imaging with Gustatory Stimulation. BMC Oral Health. 2019; 19(288): 1-10. https://doi.org/10.1186/s12903-019-0951-x .

Melek A, Durmus E, Kerem D, Ozge B, Alaattin O. Dosimetric Comparison of Single-Arc/Partial-Arc Volumetric Modulated Arc Therapy and Intensity-Modulated Radiotherapy for Peripheral and Central Lung Cancer. J Cancer Ther. 2021; 17(1): 80-87. https://www.cancerjournal.net/temp/JCanResTher17180-6846043_190100.pdf .

Hussien AA, Talib A, Aymen S, Amran A. Aqeel H. Determination of Radiation Dose from Routine X-ray Examination at Three Selected Hospitals in Al-Najaf, Iraq. Iraqi J Sci. 2019; 60(10): 2163-2167. https://doi.org/10.24996/ijs.2019.60.10 .

Yi L, Ji W, Li T, Beina H, Xiaowei M, Yanli Y, Chaofan X, et al. Juan R. Dosimetric Comparison Between IMRT and VMAT in Irradiation for Peripheral and Central Lung Cancer. Oncol Lett. 2018; 15: 3735-3745. https://pdfs.semanticscholar.org/fd6a/ff54c4c4043b01faa6cb51dd2423e7c8d1e6.pdf .

Tonghai L, Jinhu C, Guanzhong G, Guifang Z, Tong B, Tao S et al. Radiation Therapy for Nasopharyngeal Carcinoma Using Simultaneously Integrated Boost (SIB) Protocol: A Comparison Planning Study Between Intensity Modulated Arc Radiotherapy vs. Intensity Modulated. Technol Cancer Res Treat. 2012; 11(5): 415-420. https://doi.org/10.7785/tcrt.2012.500262

Khan FM, Gibbons JP, Sperduto PW.Khan’s Treatment Planning in Radiation Oncology. 4th Edition. Lippincott Williams & Wilkins. Baltimore and Philadelphia. 2021;45(5): 2351-2361. https://www.amazon.com/Khans-Treatment-Planning-Radiation-Oncology/dp/1469889978 .

Khan FM, Gibbons JP. Khan's The Physics of Radiation Therapy. 6th Ed. Wolters Kluwer Health, Lippincott Williams & Wilkins. Baltimore and Philadelphia.2020; 45(2): 598. https://doi.org/10.1002/mp.14575

Lee TF, Ting HM, Chao PJ, Wang HY, Shieh CS, Horng MF et al. Dosimetric Advantages of Generalized Equivalent Uniform Dose-Based Optimization on Dose-Volume Objectives in Intensity-Modulated Radiotherapy Planning for Bilateral Breast Cancer. Br J Radiol.. 2012; 85(1019): 1499–506. https://doi.org.10.1259/bjr/24112047

Paddick I, Lippitz B. A Simple Dose Gradient Measurement Tool to Complement the Conformity Index. J Neurosurg. 2006; 105 Suppl: 194–201. https://doi.org.10.3171/sup.2006.105.7.194 .

Aiyama H, Yamamoto M, Kawabe T, Watanabe S, Koiso T, Sato Y et al. Clinical Significance of Conformity Index and Gradient Index in Patients Undergoing Stereotactic Radiosurgery for a Single Metastatic Tumor. J Neurosurg. 2018: 29(1): 103–110. https://doi.org/0.3171/2018.6.GKS181314 .

Xiao Y, Papiez L, Paulus R, Timmerman R, Straube WL, Bosch WR et al. Dosimetric Evaluation of Heterogeneity Corrections for RTOG 0236: Stereotactic Body Radiotherapy of Inoperable Stage I-II Non-Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2009; 73(4): 1235–1242. https://doi.org/10.1016/j.ijrobp.2008.11.019

Jun Li, James G, Amy H, Robert T, Yan Yu, Ph D et al. Dosimetric Verification Using Monte Carlo Calculations for Tissue Heterogeneity-Corrected Conformal Treatment Plans Following RTOG 0813 Dosimetric Criteria for Lung Cancer Stereotactic Body Radiotherapy. Int J Radiat Oncol Biol Phys. 2012; 84(2): 508–513. https://doi.org/10.1016/j.ijrobp.2011.12.005

Jackie QR, Wu B, Wessels DB, Einstein RJ, Maciunas, EY, Kim TJ. Quality of Coverage: Conformity Measures for Stereotactic Radiosurgery. J Appl Clin Med Phys. 2003; 4(4): 3743-381. https://doi.org/10.1120/jacmp.v4i4.2506

Atheer QM. The Effect of Cold Plasma on pH, Creatine, and the Concentration of the Most Trace Elements in Human's Nails by Using X-ray Fluorescent Method. Iraqi J Sci. 2022; 63(5): 2057-2062. https://doi.org/10.24996/ijs.2022.63.5.21 .

Jamal MR, Sameer ON, Abdul S M. A Study on the Scattering and Absorption Efficiencies of Si-Ag Coaxial Nanowire. Iraqi J Sci. 2019; 60(9): 2003-2008. https://doi.org/10.24996/ijs.2019.60.9

Bin BC, Shao MH, Wei WX, Wen ZS, Ming ZL, Tai XL et al. Prospective Matched Study on Comparison of Volumetric-Modulated Arc Therapy and Intensity Modulated Radiotherapy for Nasopharyngeal Carcinoma: Dosimetry, Delivery Efficiency and Outcomes. J Cancer. 2018; 9(6): 978–986 https://doi.org/10.7150/jca.22843

Siham S A. Dosimetric Verification of Gamma Passing Rate for Head and Neck Cases Treated with Intensity Modulated Radiation Therapy (IMRT) Treatment Planning Technique. Baghdad Sci J. 2021; 18(4): 1514-1520 https://doi.org/10.21123/bsj.2021.18.4

Johnston M, Clifford S, Bromley R, Back M, Oliver L, Eade T et al. Volumetric-Modulated Arc Therapy in Head and Neck Radiotherapy: A Planning Comparison Using Simultaneous Integrated Boost for Nasopharynx and Oropharynx Carcinoma. Clin Oncol. 2011; 23(8): 503–511. https://pubmed.ncbi.nlm.nih.gov/21397477/

Ahmed I, Nowrin H, Dhar H. Stopping Power and Range Calculations of Protons in Human Tissues. Baghdad Sci J. 2020; 17(4): 1223-1233. https://doi.org/10.21123/bsj.2020.17.4.1223