Synthesis and Characterization of Grafted Chitosan Blending with Polyvinyl alcohol / Nanocomposite and Study Biological Activity
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Abstract
The study of biopolymers and their derivative materials had received a considerable degree of attention from researchers in the preparation of novel material. Biopolymers and their derivatives have a wide range of applications as a result of their bio-compatibility, bio-degradability and non-toxicity. In this paper, chitosan reacted with different aldehydes(2,4 –dichloro- benzaldehyde or 2-methyl benzaldehyde), different ketones (4-bromoacetophenone or 3-aminoacetophenone) to produce chitosan schiff base (1-4) . Chitosan schiff base (1-4) reacted with glutaric acid or adipic acid in acidic media in distilled water according to the steps of Fischer and Speier to produce compounds (5-12) respectively. Grafted chitosan (5-12) blended with synthetic polymer PVA to produce compounds (13-20), then these polymers were blended with nano Ag by using a hotplate stirrer for 60 min to produce nanocomposites. The synthesized polymers were identified via spectral analysis techniques, including FTIR , 1H-NMR and scanning electron microscope (SEM). Finally, studied anti-bacterial activities of some of the prepared polymers.
Received 19/6/2022, Revised 10/9/2022, Accepted 12/9/2022, Published Online First 20/2/2023
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Ali A. Taha, Nahida J. Hameed, Farah H. Rashid. Decolorization of Phenol Red Dye by Immobilized Laccase in Chitosan Beads Using Laccase -Mediator -System Model. Baghdad Sci J. 2020; 17(3): 720-725.
Riccardo Fontana, Peggy Carla Raffaella Marconi, Antonella Caputo, Vasak B. Gavalyan. Novel Chitosan-Based Schiff Base Compounds:Chemical Characterization and Antimicrobial Activity. Mol. 2022; 27: 2740.
Mahmoud T. Mahboub, Mostafa I. Hassan, Ahmed S. Bream, Aly F. Mohamed. Antibacterial and antiviral activities of chitosan nanoparticles from the American cockroach, Periplaneta Americana. J App Pharm Sci. 2022; 12(03): 202-208.
Bakshi PS, Selvakumar D, Kadirvelu K, Kumar NS. Chitosan as an environment friendly biomaterial - a review on recent modifications and applications. Int J Biol Macromol. 2020; 150: 1072-83.
Olivia Hanaa Raouf, Samy Selim, Hussein Mohamed, Omayma Fawazy Abdel-Gawad, Ali Mahmoud Elzanaty, Sayed Abdel-Kader Ahmed. Synthesis, characterization and biological activity of Schiff bases based on chitosan and acetophenone derivatives. Adv J Chem A. 2020; 3(3): 274-282.
Mohaddeseh Kariminejad, Rezvan Zibaei, Azin Kolahdouz-Nasiri, Reza Mohammadi, Amir M Mortazavian, Sara Sohrabvandi, et al. Chitosan/Polyvinyl Alcohol/SiO2 Nanocomposite Films:Physicochemical and Structural Characterization. Biointerface Res Appl Chem. 2022; 12(3): 3725-3734.
Piosik E, Ziegler-Borowska M, Chelminiak-Dudkiewicz D, Martynski T. Effect of Aminated Chitosan-Coated Fe3O4 Nanoparticles with Applicational Potential in Nanomedicine on DPPG, DSPC, and POPC Langmuir Monolayers as Cell Membrane Models. Int J Mol Sci. 2021; 22(5): 2467.
Alexander Pestov, Yuliya Privar, Arseny Slobodyuk, Andrey Boroda, Svetlana Bratskaya. Chitosan Cross-Linking with Acetaldehyde Acetals. Biomimetics. 2022; 7(1): 1-10.
El-Shahawy AA G, Kamal W, Sayed O M, El Rouby W M A, Zahran H Y, Yahia I S, et al. Preparation and characterization of ketoprofen and pentoxifylline agents based layered double hydroxides-chitosan nanohybride and its releasing control. Dig J Nanomater Bios. 2022; 17(2):527-540.
Ali A Taha, Nahida J Hameed, Farah H Rashid, Preparation and Characterization of (Hyacinth plant / Chitosan) Composite as a Heavy Metal Removal. Baghdad Sci J. 2019; 16(4): 865-870.
Hitesh Chopra, Shabana Bibi, Sandeep Kumar, Muhammad Saad Khan, Pradeep Kumar, Inderbir Singh. Preparation and Evaluation of Chitosan/PVA Based Hydrogel Films Loaded with Honey for Wound Healing Application. Gels. 2022; 8(2): 111.
Ewa Olewnik-Kruszkowska, Magdalena Gierszewska, Ewelina Jakubowska, Iwona Tarach, Vladimir Sedlarik, Martina Pummerova. Antibacterial Films Based on PVA and PVA–Chitosan Modified with Poly (Hexamethylene Guanidine). Polymers. 2019; 11(12): 2093.
Chen J, Wei D, Gong W, Zheng A, Guan Y. Hydrogen-Bond Assembly of Poly(vinyl alcohol) and Polyhexamethylene Guanidine for Nonleaching and Transparent Antimicrobial Films. ACS Appl Mater Interfaces. 2018; 10(43): 37535-37543.
Hanaa J. Alesa, Balqees M. Aldabbag, Rana M. Salih. Natural Pigment –Poly Vinyl Alcohol Nano composites Thin Films for Solar Cell. Baghdad Sci J. 2020; 17(3): 832-840
Ahmed A.Ounab, Gye HwaShinc, Jun TaeKima. Antimicrobial, antioxidant, and pH-sensitive polyvinyl alcohol/chitosan-based composite films with aronia extract, cellulose nanocrystals, and grapefruit seed extract. Int J Biol Macromol. 2022; 213: 381-393.
Emad Soliman, Salah M. El-Kousy, Hammed M. Abd-Elbary, Ahmed R. Abou-zeid. Low Molecular Weight Chitosan-based Schiff Bases: Synthesis, Characterization and Antibacterial Activity. Am J Food Technol. 2013; 8(1): 17-30.
Badawy MEI, Rabea EI. Preparation and antimicrobial activity of O-(benzoyl) chitosan derivatives against some plant pathogens. Afr J Microbiol Res. 2013; 7(20): 2259-2268.
Li X, Goh SH, Lai YH, Wee ATS. Miscibility of carboxyl-containing polysiloxane/poly (vinylpyridine) blends. Polymer. 2000; 41(17): 6563-6571.
Hafeez H. Y, Lakhera S. K, Ashokkumar M, Neppolian B. Ultrasound assisted synthesis of reduced graphene oxide (rGO) supported InVO4-TiO2 nanocomposite for efficient hydrogen production. Ultrason Sonochem. 2019; 53: 1-10.
Ruwaidah S. Saeed. Synthesis and Characterization of O-(carboxyl) Chitosan Schiff Base Derivatives and Study Antibacterial Activity. Int J Drug Deliv Technol. 2020; 10 (3): 402-407.
Ruwaidah S. Saeed, Muna S. AL-Rawi. Synthesis, Characterization, Study the Toxicity and Anticancer Activity of N,O-Chitosan Derivatives. J Pharm Sci Res. 2020; 12 (2): 1197-1206.
Esam A. EL-hefia, Mohamed Mahmoud Nasef, Abdul Hamid Yahaya. Preparation and Characterization ofChitosan/Poly(Vinyl Alcohol) Blended Films:Mechanical, Thermal and Surface Investigations. E-J Chem. 2011; 8(1): 91-96.
Mohammed A. Almualla, Mazin N.Mousa, Mohammed Sattar. Chemical Modification and Characterization of Chitosan for Pharmaceutical Applications. Egypt J Chem. 2021; 64(7): 3635-3649.
Parul Sharma, Garima Mathur, Navendu Goswami, Sanjeev K Sharma, Sanjay R Dhakate, Subhash Chand, et al. Evaluating the potential of chitosan/poly(vinyl alcohol) membranes as alternative carrier material for proliferation of Vero cells. E-Polym. 2015; 15(4): 237–243.
Hezma A.M, Rajeh A, Mannaa M. A. An insight into the effect of zinc oxide nanoparticles on the structural, thermal, mechanical properties and antimicrobial activity of Cs/PVA composite. Colloids Surf A Physicochem Eng Asp. 2019; 581(20): 123821.
Boomi P, Prabu H G, Mathiyarasu J. synthesis, characterization and antibacterial activity of polyaniline/Pt-Pd nanocomposite. Colloids Surf B: Biointerfaces. 2013; 103: 9-14.
Kim S H,Lee H S, Ryu D S, Choi S J, Lee D S. Antibacterial Activity of Silver-nanoparticles Against Staphylococcus aureus and Escherichia coli. Microbial Biotechnol Lett. 2011; 39(1): 77-85.
Prabhu S, Poulose E K, Silver nanoparticles: mechanism of antimicrobial action. synthesis, medical applications and toxicity effects. Int Nano Lett. 2012; 2(1): 1-10.
Aalaa B Nashter, Maha A Younus. Preparation, Characterization and Antimicrobial Activity of Polyvinylalcohol/Polyvinylpyrrolidone/ Chitosan Nano composite. Biochem Cell Arch. 2021; 21(2): 4513-4519. https://connectjournals.com/03896.2021.21.4513.
Danilcauk M, Lund A, Sadlo J, Yamada H, Michalik J, Conduction electron spin resonance of small silver particles. Spectrochim Acta A Mol Biomol Spectrosc. 2006; 63(1): 189-191.
Brian Y Feng, Brandon H Toyama, Holger Wille, David W Colby, Sean R Collins, Barnaby C H May, et al. Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol. 2008; 4(3): 197-199.
Shrivastava S, Bera T, Roy A, Singh G, Ramachandrarao P,Dash D. Characterization of enhanced antibacterial effects of novel silver nanoparticles. Nanotechnol. 2007; 18(22): 225103.
Jabir M S, Hussien A A, Sulaiman G M, Yaseen N Y, Dewir Y H, Alwahibi M S, et al. Green synthesis of silver nanoparticles from Eriobotrya japonica extract: a promising approach against cancer cells proliferation, inflammation, allergic disorders and phagocytosis induction. Artif Cells Nanomed. Biotechnol. 2021; 49(1): 48-60.
Majid S Jabir, Yasmin M Saleh, Ghassan M Sulaiman, Nahi Y Yaseen, Usama I Sahib, Yaser Hassan Dewir, et al. Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy. J Nanomater. 2021; 11(2): 384.