Main Article Content
Vitamin K-dependent protein (VKDP) contributes to the development of lung cancer. The purpose of this research was to better understanding of the role of blood matrix Gla protein (MGP), VKDPs, Malondialdehyde (MDA), Superoxide dismutase (SOD) and Vitamin K (Vit K) in Iraqi patients with lung cancer before and after the first cycle of chemotherapy. Blood samples were collected from Al amal National Hospital for cancer treatment from October 2021 to May 2022, and a total of 80 samples were collected, divided into two groups (40 patient before taking a chemotherapy and 40 patients after taking chemotherapy), ranging in age from 20 to 45 years old. The results showed that although there were highly statistically significant differences in MDA, VKDPS, SOD, and Vit K, there was no difference in MGP serum levels between the two groups (P = 0.05). The current study found a significant positive correlation between MGP and VK1 values.Correlations before and after treatment. Based on the results obtained, no role for the blood matrix protein Gla was observed in patients after and before treatment. Therefore, it cannot be considered a sign of patients' response to treatment. In addition, it was observed that lung cancer patients had lower levels of SOD enzyme, which indicates the effect of treatment on the disease, in which knowing the extent to which the body is responding or not responding to treatment.
Published Online First 25/11/2022
This work is licensed under a Creative Commons Attribution 4.0 International License.
Barta JA, Powell CA, Wisnivesky JP. Global Epidemiology of Lung Cancer. Ann Glob Health. 2019 Jan 22; 85(1):8. doi: 10.5334/aogh.2419. https://doi.org/10.5334/aogh.2419.
Al-Taee MF, Al-Shaibany AW, Al-Hadeithy MR. Evaluation for the Effect of Heat Stable Enterotoxin (a) Produced by Enterotoxigenic Escherichia coli on Different. Baghdad Sci J. 2010 Mar 7; 7(1) 401-10. https://doi.org/10.21123/bsj.2010.7.1.401-410 .
Gaschler MM, Stockwell BR. Lipid peroxidation in cell death. Biochem Biophys Res Commun. 2017 Jan 15; 482(3): 419-25.https://doi.org/10.1016/j.bbrc.2016.10.086.
Wen L, Chen J, Duan L, Li S. Vitamin K‑dependent proteins involved in bone and cardiovascular health. Mol Med Rep. 2018 Jul 1; 18(1): 3-15. https://doi.org/10.3892/mmr.2018.8940.
Donaldson CJ, Harrington DJ. Therapeutic warfarin uses and the extrahepatic functions of vitamin K-dependent proteins. Br. J Biomed. Sci. 2017 Oct 2; 74(4): 163-9. https://doi.org/10.1080/09674845.2017.1336854.
Aguilera-Méndez A, Boone-Villa D, Nieto-Aguilar R, Villafaña-Rauda S, Molina AS, Sobrevilla JV. Role of vitamins in the metabolic syndrome and cardiovascular disease. Pflug. Arch Eur J Phy. 2021 Sep 13: 1-24. https://doi.org/10.1007/s00424-021-02619-x.
Gahunia HK, Pritzker KPH. Structure and Function of Articular Cartilage. In: Gahunia H., Gross A., Pritzker K., Babyn P., Murnaghan L. (eds) Articular Cartilage of the Knee.2020 May 10. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7587-7-1.
Zandueta C, Ormazábal C, Perurena N, Martínez‐Canarias S, Zalacaín M, Julián MS, etal. Matrix‐Gla protein promotes osteosarcoma lung metastasis and associates with poor prognosis. J Pathol. 2016 Aug; 239(4): 438-49. https://doi.org/10.1002/path.4740.
Paul A, Basu S, Debnath M, Barman AK. A veteran vitamin in versatile role: Vit K. The Pharma Innovation J. 2018; 7(9): 337-342. https://www.thepharmajournal.com
Sainz de Aja J, Dost AF, Kim CF. Alveolar progenitor cells and the origin of lung cancer. J Intern Med. 2021 May; 289(5): 629-35. https://doi.org/10.1111/joim.13201.
AL-Jubori SS, Ali MA, Ali AM. Bacteriological and Cytological study for bronchial washes from lung cancer patients. Baghdad Sci J. 2011; 8(1):406-15 Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2511
Sterzyńska K, Klejewski A, Wojtowicz K, Świerczewska M, Andrzejewska M, Rusek D, etal. The role of matrix gla protein (MGP) expression in paclitaxel and topotecan resistant ovarian cancer cell lines. Int. J Mol. Sci. 2018 Sep 25; 19(10): 2901. https://doi.org/10.3390/ijms19102901.
Nowacka M, Sterzynska K, Andrzejewska M, Nowicki M, Januchowski R. Drug resistance evaluation in novel 3D in vitro model. Biomed Pharmacother. 2021 Jun 1; 138(special issue): 111536. https://doi.org/10.1016/j.biopha.2021.111536
Crintea A, Dutu AG, Constantin AM, Fekete Z, Samasca G, Lupan I, etal. The First Evaluation of Serum Levels of MGP, Gas6 and EGFR after First Dose of Chemotherapy in Lung Cancer. Biology. 2022 Jan 6; 11(1): 82. https://doi.org/10.3390/biology11010082.
Zheng ZG, Sun WZ, Hu JY, Jie ZJ, Xu JF, Cao J, etal. Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial. Respir Res. 2021 Dec; 22(1): 1-2. https://doi.org/10.1186/s12931-021-01740-w.
Skórska KB, Płaczkowska S, Prescha A, Porębska I, Kosacka M, Pawełczyk K, etal. Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients. Pharmaceuticals. 2021 Oct 21; 14(11): 1067. https://doi.org/10.3390/ph14111067.
Puliafito I, Esposito F, Raciti G, Giuffrida P, Caltavuturo C, Colarossi C, etal. Metabolic complete tumor response in a patient with epidermal growth factor receptor mutant non-small cell lung cancer treated with a reduced dose of afatinib. J Inter Med R. 2022Mar 15. https://doi.org/10.1177/03000605211058864.