Role of IL-37 and Dectin-1 during Toxoplasmosis

Authors

  • Zahra’a A. Ahmed Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq. https://orcid.org/0000-0003-3232-6454
  • Ekhlas M. Idan Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq.
  • Naksheen M. Ardalan Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq. https://orcid.org/0000-0002-5683-6355

DOI:

https://doi.org/10.21123/bsj.2022.7618

Keywords:

C-type lectin receptor, Cytokine, Dectin-1, IL-37, Miscarriage, Toxoplasmosis

Abstract

Toxoplasmosis is a parasitic infection that triggers immune cells to produce cytokines and inflammatory mediators that are responsible for abnormal or aborted immune responses. This study highlights the evaluation of the Dectin-1 receptor and cytokine IL-37 in the serum of 80 patients who had miscarried in the first trimester and were infected with toxoplasmosis, as well as 40 pregnant women in the first trimester who had a successful pregnancy (control groups). The serum was first screened for the T. gondii IgM and IgG antibodies by an enzyme-linked immunosorbent assay (ELISA) and then the serum levels of IL-37 and Dectin-1 were determined. The results showed that the serum level of Dectin-1 was significantly increased in anti-Toxoplasma IgM and IgG patients 362.382 ± 45.937 and 361.916 ± 71.993 ng/L respectively, as compared with the controls 155.702 ± 26.356 ng/L, while the serum level of IL-37 was convergent in anti-Toxoplasma IgM and IgG patients and controls 52.666 ± 4.272, 66.808 ± 9.132, and 51.984 ± 3.619 ng/L respectively, with no significant differences. In conclusion, Dectin-1 receptor may play a role in pregnancy loss, especially in T. gondii infection.

References

Ismael AK, Salih TA. Studying the Role of IFN-γ, Vitamin C, SOD, LH, FSH, APA and ACA in Toxoplasma gondii Infected Miscarriage Women. Baghdad Sci.J. 2019 Sep.22; 16(3):0697. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/4126.

Almeria S, Dubey JP. Foodborne transmission of Toxoplasma gondii infection in the last decade. An overview. Res Vet Sci. 2021 Mar; 135:371-385. https://doi.org/10.1016/j.rvsc.2020.10.019. Epub 2020 Oct 24. PMID: 33148402.

Tomasoni LR, Messina G, Genco F, Scudeller L, Prestia M, Spinoni V, et al. Risk of congenital toxoplasmosis in women with low or indeterminate anti-Toxoplasma IgG avidity index in the first trimester of pregnancy: an observational retrospective study. Clin Microbiol Infect. 2019 Jun;25(6):761.e9-761.e13. https://doi.org/10.1016/j.cmi.2018.09.024. Epub 2018 Oct 11. PMID: 30315959.

Sasai M, Pradipta A, Yamamoto M. Host immune responses to Toxoplasma gondii. Int Immunol. 2018 Mar 10; 30 (3): 113-119. https://doi.org/10.1093/intimm/dxy004. PMID: 29408976.

Blanchard N, Dunay IR, Schlüter D. Persistence of Toxoplasma gondii in the central nervous system: a fine-tuned balance between the parasite, the brain and the immune system. Parasite Immunol. 2015 Mar; 37(3):150-8. https://doi.org/10.1111/pim.12173. PMID: 25573476.

Abdollahi SH, Ayoobi F, Khorramdelazad H, Hassanshahi G, Ahmadabadi BN, Rezayati M, et al. Interleukin-10 Serum Levels after Vaccination with In Vivo Prepared Toxoplasma gondii Excreted/Secreted Antigens. Oman Med J. 2013 Mar; 28 (2):112-5. https://doi.org/10.5001/omj.2013.29. PMID: 23599879; PMCID: PMC3628197.

Ma J, Zhang X, He G, Yang C. Association between TNF, IL1B, IL6, IL10 and IFNG polymorphisms and recurrent miscarriage: a case control study. Reprod Biol Endocrinol. 2017 Oct 10; 15 (1):83. https://doi.org/10.1186/s12958-017-0300-3. PMID: 29017513; PMCID: PMC5634870.

El-Sherbini MS, Abd El-Aal AA, El-Sherbiny WS, Attia SS, Abdel Aziz IZ, Nasr GM, et al. Toxoplasmosis and abortion: pro- and anti-inflammatory cytokines gene expression of the host immune cells. Egypt J Med Hum Genet. 2019 Aug 15; 20, (3):1-10. https://doi.org/10.1186/s43042-019-0006-5.

Snyder LM, Denkers EY. From Initiators to Effectors: Roadmap through the Intestine during Encounter of Toxoplasma gondii With the Mucosal Immune System. Front Cell Infect Microbiol. 2021 Jan 11; 10: 614701. https://doi.org/10.3389/fcimb.2020.614701. PMID: 33505924; PMCID: PMC7829212.

Mata-Martínez P, Bergón-Gutiérrez M, Del Fresno C. Dectin-1 Signaling Update: New Perspectives for Trained Immunity. Front Immunol. 2022 Feb 14; 13:812148. https://doi.org/10.3389/fimmu.2022.812148. PMID: 35237264; PMCID: PMC8882614.

Gigley JP. The Diverse Role of NK Cells in Immunity to Toxoplasma gondii Infection. PLoS Pathog. 2016 Feb 25; 12 (2):e1005396. https://doi.org/10.1371/journal.ppat.1005396. PMID: 26915066; PMCID: PMC4767437.

Mévélec MN, Lakhrif Z, Dimier-Poisson I. Key Limitations and New Insights Into the Toxoplasma gondii Parasite Stage Switching for Future Vaccine Development in Human, Livestock, and Cats. Front Cell Infect Microbiol. 2020 Nov 25; 10:607198. https://doi.org/10.3389/fcimb.2020.607198. 607198. PMID: 33324583; PMCID: PMC7724089.

Bai J, Li Y, Li M, Tan S, Wu D. IL-37 As a Potential Biotherapeutics of Inflammatory Diseases. Curr Drug Targets. 2020; 21 (9): 855-863. https://doi.org/10.2174/1389450121666200429114926. PMID: 32348214.

Calabrese L, Fiocco Z, Satoh TK, Peris K, French LE. Therapeutic potential of targeting interleukin-1 family cytokines in chronic inflammatory skin diseases. Br J Dermatol. 2022 Jun;186(6):925-941. https://doi.org/10.1111/bjd.20975. Epub 2022 Mar 22. PMID: 34990008.

Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA. IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol. 2010 Nov;11(11):1014-22. https://doi.org/10.1038/ni.1944. Epub 2010 Oct 10. PMID: 20935647; PMCID: PMC3537119.

Wang L, Quan Y, Yue Y, Heng X, Che F. Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy. Oncol Lett. 2018 Apr; 15 (4): 4711-4719. https://doi.org/10.3892/ol.2018.7982. Epub 2018 Feb 7. PMID: 29552110; PMCID: PMC5840652.

Salih JM, Mero WMM, Eassa S. Seroprevalence and some Demographic Factors Associated with Toxoplasma gondii Infection among Male Population in Duhok Province/Iraq. Baghdad Sci.J. 2020 May10; 17(2):0431. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3962

Saheb EJ, Al-Issa YA, Mussa IS, Zghair KH. Incidence of Toxoplasmosis in Psoriasis Patients and Possible Correlation with Tumor Necrosis Factor-α. Baghdad Sci.J. 2020 Mar.18;17(1(Suppl.):0214. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2981.

Vassiliadis S, Ranella A, Papadimitriou L, Makrygiannakis A, Athanassakis I. Serum levels of pro- and anti-inflammatory cytokines in non-pregnant women, during pregnancy, labour and abortion. Mediators Inflamm. 1998; 7(2):69-72. https://doi.org/10.1080/09629359891199. PMID: 9836491; PMCID: PMC1781827.

Makhseed M, Raghupathy R, Azizieh F, Farhat R, Hassan N, Bandar A. Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions. Hum Reprod. 2000 Sep;15(9):2011-7. https://doi.org/10.1093/humrep/15.9.2011. PMID: 10967006.

Kwiatek M, Gęca T, Kwaśniewska A. Pro- and Anti-Inflammatory Cytokines in the First Trimester-Comparison of Missed Miscarriage and Normal Pregnancy. Int J Environ Res Public Health. 2021 Aug 12; 18 (16): 8538. https://doi.org/10.3390/ijerph18168538. PMID: 34444287; PMCID: PMC8393667.

da Silva MV, Ferreira França FB, Mota CM, de Macedo Júnior AG, Ramos EL, Santiago FM, et al. Dectin-1 Compromises Innate Responses and Host Resistance against Neospora caninum Infection. Front Immunol. 2017 Mar 7; 8:245. https://doi.org/10.3389/fimmu.2017.00245. PMID: 28326085; PMCID: PMC5339258.

Worth DL. Immune Response to Developmentally-Dependent Expression of Toxoplasma gondii Antigens. PhD [dissertation]. University of California; September 2017. https://escholarship.org/uc/item/3mh2j5w6.

Lima-Junior DS, Mineo TWP, Calich VLG, Zamboni DS. Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication. J Immunol. 2017 Sep 15;199(6):2055-2068. https://doi.org/10.4049/jimmunol.1700258. Epub 2017 Aug 7. PMID: 28784846.

Tone K, Stappers MHT, Willment JA, Brown GD. C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease. Eur J Immunol. 2019 Dec; 49(12):2127-2133. https://doi.org/10.1002/eji.201847536. Epub 2019 Nov 13. PMID: 31580478; PMCID: PMC6916577.

Fabian BT, Lepenies B, Schares G, Dubey JP, Spano F, Seeber F. Expanding the Known Repertoire of C-Type Lectin Receptors Binding to Toxoplasma gondii Oocysts Using a Modified High-Resolution Immunofluorescence Assay. mSphere. 2021 Mar 31;6(2):e01341-20. https://doi.org/10.1128/mSphere.01341-20. PMID: 33789945; PMCID: PMC8546727.

Upchurch K, Oh S, Joo H. Dectin-1 in the control of Th2-type T cell responses. Receptors Clin Investig. 2016 Jan 1;3(1):e1094. https://doi.org/10.14800/rci.1094. Epub 2016 Jan 4. PMID: 27088111; PMCID: PMC4831730.

Ding VA, Zhu Z, Mantz AA, Xiao H, Wakefield MR, Bai Q, et al. The Role of IL-37 in Non-Cancerous Diseases. Pathol Oncol Res. 2017 Jul;23(3):463-470. https://doi.org/10.1007/s12253-016-0137-7. Epub 2016 Oct 27. PMID: 27787707.

Bello RO, Chin VK, Abd Rachman Isnadi MF, Abd Majid R, Atmadini Abdullah M, Lee TY, et al. The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis. Int J Mol Sci. 2018 Apr 11;19(4):1149. https://doi.org/10.3390/ijms19041149. PMID: 29641433; PMCID: PMC5979316.

Cavalli G, Tengesdal IW, Gresnigt M, Nemkov T, Arts RJW, Domínguez-Andrés J, et al. The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity. Cell Rep. 2021 Apr 6;35(1):108955. https://doi.org/10.1016/j.celrep.2021.108955. PMID: 33826894.

Catalan-Dibene J, McIntyre LL, Zlotnik A. Interleukin 30 to Interleukin 40. J Interferon Cytokine Res. 2018 Oct;38(10):423-439. https://doi.org/10.1089/jir.2018.0089. PMID: 30328794; PMCID: PMC6206549.

Zhao M, Li Y, Guo C, Wang L, Chu H, Zhu F, et al. IL-37 isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner. Cell Death Dis. 2018 May22; 9(6): 582. https://doi.org/10.1038/s41419-018-0664-0.

Pan Y, Wen X, Hao D, Wang Y, Wang L, He G, et al. The role of IL-37 in skin and connective tissue diseases. Biomed Pharmacother. 2020 Feb;122:109705. https://doi.org/10.1016/j.biopha.2019.109705. Epub 2019 Dec 30. PMID: 31918276.

Garlanda C, Dinarello CA, Mantovani A. The interleukin-1 family: back to the future. Immunity. 2013 Dec 12;39(6):1003-18. https://doi.org/10.1016/j.immuni.2013.11.010. PMID: 24332029; PMCID: PMC3933951.

Quirk S, Agrawal DK. Immunobiology of IL-37: mechanism of action and clinical perspectives. Expert Rev Clin Immunol. 2014 Dec;10(12):1703-9. https://doi.org/10.1586/1744666X.2014.971014. Epub 2014 Oct 18. PMID: 25327443; PMCID: PMC4596230.

Conti P, Caraffa A, Mastrangelo F, Tettamanti L, Ronconi G, Frydas I, et al. Critical role of inflammatory mast cell in fibrosis: Potential therapeutic effect of IL-37. Cell Prolif. 2018 Oct; 51(5):e12475. https://doi.org/10.1111/cpr.12475. Epub 2018 Jul 30. PMID: 30062695; PMCID: PMC6528914.

Downloads

Published

2023-06-01

Issue

Section

article

How to Cite

1.
Role of IL-37 and Dectin-1 during Toxoplasmosis. Baghdad Sci.J [Internet]. 2023 Jun. 1 [cited 2024 Nov. 6];20(3):0746. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7618

Similar Articles

You may also start an advanced similarity search for this article.