Fabrication of PVC Enrofloxacin-Selective Electrodes for Estimating Enrofloxacin in Pure Form and as Preparation Formula
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Abstract
This study explored the development and qualities of the response of electrochemical properties of enrofloxacin-selective electrodes using precipitation based on producing phosphotungstic, after utilizing a matrix of polyvinyl chloride (PVC) and dibutyl phthalate or dibutyl phosphate as a plasticizer. The resulting membrane sensors were an enrofloxacin-phosphotungstic electrode (sensors 1) and an ENR-DOP-PTA electrode (sensors 2). Linear responses of (ENR-DBPH-PTA) and (ENR-DOP-PTA) within the concentration ranges of 2.1×10-6-10-1 and 3.0×10-6-10-2 mol. L-1, respectively, for both sensors were observed. Slopes of 51.61±0.24 and 39.40± 0.16 mV/decade and pH ranges equal to 2.5-8.5 and 2.0-9.0 were observed for sensors 1 and 2, respectively. The coefficients of selectivity of the created sensors demonstrated phenomenal selectivity for ENR. The proposed sensors showed useful scientific properties for the assurance of ENR in drug dosage and pure form.
Received 1/10/2022, Revised 9/12/2022, Accepted 11/12/2022, Published Online First 20/4/2023
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Temmerman R, Pelligand L, Schelstraete W, Antonissen G, Garmyn A, Devreese M. Enrofloxacin Dose Optimization for the Treatment of Colibacillosis in Broiler Chickens Using a Drinking Behaviour Pharmacokinetic Model. Antibiotics. 2021;10:604-609 https://doi.org/10.3390/antibiotics10050604.
Arslan- Acaröz D, Sözbilir N B. Investigation of enrofloxacin and ciprofloxacin residues by LC-MS/MS in chicken liver marketed in Afyonkarahisar. Ankara Üniv Vet Fak Derg. 2020; 67: 137-142. https://doi.org/10.33988/auvfd. 561824 .
Zordok W A, Sadeek S A. Synthesis, thermal analyses, characterization and biological evaluation of new enrofloxacin vanadium(V) solvates(L) (L = An, DMF, Py, Et3N and o-Tol). J Mol Struct. 2016; 1120: 50-61. https://doi.org/10.1016/j.molstruc.2016.05.011 .
Petrović J, Kartalović B, Ratajac R, Radulović J P, Stojanov I, Žekić M, et al. Detection of enrofloxacine residues by microbiological screening method. Biotechnol Anim Husb. 2019; 35 (1): 49-59. https://doi.org/10.2298/BAH1901049P
Majdi N A, John W W, Brian D L, Beta-lactam and fluoroquinolone combination antibiotic therapy for bacteremia caused by gram-negative bacilli. Chin J Inf Chemother. 2010; 53(4): 1386. https://doi.org/10.1128/AAC.01231-08 .
Ding Y, Yuchang P, Prasad Ch V N S V,Wang B. Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin. Drug Deliv. 2020; 27 (1): 334–343 https://doi.org/10.1080/10717544.2020.1724210
Elmahadil J O,Shantier Sh W A,Adam M E .Development and Validation of UV–Spectrophotometric method for the Determination of Enrofloxacin in Synthetic form and Veterinary Injectibleo Dsage forms. Asian J Pharm. Anal 2019; 9 (1) 11-14. https://doi.org/10.5958/2231-5675.2019.00004.8 .
Zareh M,Saad M Z,Hassan W,Elhennawy M E,Sebaiy M M .Validation of spectrophotometric method for determination of esomeprazole and ciprofloxacin in their pure and dosage forms. Int J Pharm Sci Dev Res. 2020; 6(1):001-005. https://doi.org/10.17352/ijpsdr.000024 .
Pei L, Yang W, Fu J, Liu M, Zhang T, Li D, Huang R, et al. Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate. Drug Des Devel Ther.2020; 14: 715-730. https://doi.org/10.2147/DDDT.S239307.
Araujo E O, Rosa A M, Amaral M S, Sversut R A, Baroni A C M, Oliveira L C S, et al. Stability-indicating HPLC-DAD method for the simultaneous determination of fluoroquinolone in combination with a non‑steroidal anti-inflammatory drug in pharmaceutical formulation. Braz J Pharm. Sci .2020; 56: e17758. https://doi.org/10.1590/s2175-97902019000417758.
Krishna A, Kishore J, Prasadaro K. A Novel Validated Headspace Gas Chromotography Method for the Simultaneous Quantification of three Organic Volatile Impurities in Enrofloxacin pure and Pharmaceutical Dosage Forms. Asian J Pharm Clin Res.2020; 13(11):171-177. https://doi.org/10.22159/ajpcr.2020.v13i11.39732.
Moed S, Hall M, Lee N, Costa C P, Rødland E K, Shemirani A I, et al. Quantitative assay for ciprofloxacin and enrofloxacin formulations. J Glob Health. 2019; 3: 1-8 https://doi.org/10.29392/joghr.3.e2019044
Ma L, Liu B, Wang Ch, Zhang H, Cheng X. Environmental and Biological Engineering The Investigation of Fluorescence Spectra and Fluorescence Quantum Yield of Enrofloxacin. J Chem. 2018;2(1):11-16. https://dx.doi.org/10.11648/J.JCEBE.20180201.13
Canalesa C, Peralta E, Antilen M. Electrochemical techniques to detect and quantify Enrofloxacin in presence of highly potential interferences: Assays in Chilean aqueous-soil matrices. J Electroanal Chem, 2019; 832: 329-335. https://dx.doi.org/10.1016/j.jelechem.2018.10.064 .
Abdel-Haleem F M, Mahmoud S , Nour Eldin T, Abdel-Ghani N T, El Nashar R M , Bechelany M. et al. Polyvinyl Chloride Modified Carbon Paste Electrodes for Sensitive Determination of Levofloxacin Drug in Serum, Urine, and Pharmaceutical Formulations. Sensors 2021; 21(3150):1-23. https://dx.doi.org/10.3390/s21093150.
Abass A M. Synthesis New Liquid Selective Electrodes of Ciprofloxacin Hydrochloride for Determination Ciprofloxacin in Pure form and Pharmaceuticals Preparation, Baghdad Sci. J. 2017; 14(4):787-792. https://doi.org/10.21123/bsj.2017.14.4.0787.
Abass A M, Preparation Pilocarpine Hydrochloride Selective Electrodes. ANJS. 2017; 20(4):13-19.
Al-Saidi K.H, Aziz W R. Construction of New Ion Selective Electrodes for Determination Fe(III) and Their Application in Pharmaceutical samples, Baghdad Sci J. 2013;10(4): 1211-1217.