Estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapy
DOI:
https://doi.org/10.21123/bsj.2024.8282Keywords:
Acute myeloid leukemia, homocysteine, malondialdehyde, peroxynitrite, uric acidAbstract
The aim of this study was to measure the levels of malondialdehyde (MDA), peroxynitrite (PN), homocysteine (HCY), and uric acid (UA) in acute myeloid leukemic patients (AML) (before and after taking chemotherapy) and compare results with a healthy control group. The present study includes 120 age ranged 18-70 years old suffered from AML as well as 40 healthy group. Subjects were collected from patients and a control group at Erbil’s Nanakali Hospital, they were classified into four groups: Group 1 (G1) which includes 40 healthy subjects, Group 2 (G2) includes 40 AML patients before taking chemotherapy (newly diagnosed cases), Group 3 (G3) includes 40 AML patients after taking chemotherapy (one cycle) and Group 4 (G4) includes 40 AML patients after taking chemotherapy (more than one cycle). The results have shown a high significantly increased in levels of (MDA and UA), and significantly increased in PN in all patient groups (G1, G2, and G3) when compared to (G1). While homocysteine was a high significantly increased in (G2) when compared to (G1), and high significantly decreased in (G3 and G4) as compared to (G1). Additionally, the correlation analysis has shown that there was a significant positive correlation between malondialdehyde and peroxynitrite (r=0.4638), malondialdehyde and homocysteine (r=0.4752), and malondialdehyde with uric acid (r=0.3621). A high area under the curve of our data suggests that the determination of these parameters could be helpful to detect AML
Received 26/12/2022
Revised 23/06/2023
Accepted 25/06/2023
Published Online First 20/01/2024
References
Shafique S, Tehsin S. Acute lymphoblastic leukemia detection and classification of its subtypes using pretrained deep convolutional neural networks. Technol Cancer Res Treat. 2018; 17: 1533033818802789. https://doi.org/10.1177/1533033818802789.
Ahmed N, Yigit A, Isik Z, Alpkocak A. Identification of leukemia subtypes from microscopic images using convolutional neural network. Diagnostics (Basel). 2019; 9(3): 104. https://doi.org/10.3390/diagnostics9030104.
San José-Enériz E, Gimenez-Camino N, Agirre X, Prosper F. HDAC inhibitors in acute myeloid leukemia. Cancers (Basel). 2019; 11(11): 1794. https://doi.org/10.3390/cancers11111794.
Zakeri N, Asbaghi O, Naeini F, Afsharfar M, Mirzadeh E, kasra Naserizadeh S. Selenium supplementation and oxidative stress: A review. Pharma Nutrition. 2021; 17: 100263. https://doi.org/10.1016/j.phanu.2021.100263.
Owoade AO, Adetutu A, Olorunnisola OS. Free radicals as mediators of oxidative damage and disease. IOSR J Pharm Biol Sci. 2019; 14(2): 57-64. http://dx.doi.org/10.9790/3008-1402025764.
Priyanka G, Elumalai K. Protective role of Maha Vallathy Leghiyam on 4-nitroquinoline-1-oxide-induced experimental oral carcinogenesis. Drug Invent Today. 2019; 11(11).
Purwati DD, Mustika A, Hakim L, Thaha M. Correlation of Serum Nitric Oxide and Urine Malondialdehyde Levels in Non-Hemodialysis Chronic Kidney Disease Patients. MCBS. 2022; 6(1): 43-9. https://doi.org/10.21705/mcbs.v6i1.226.
Aldeen YM, Habeeb P, Jawad AH. Study Oxidative Stress Statues In Hypertension Women. Baghdad Sci J. 2016; 13(2S): 407-413. http://dx.doi.org/10.21123/bsj.2016.13.2.2NCC.0407.
Ferrer-Sueta G, Campolo N, Trujillo M, Bartesaghi S, Carballal Sn, Romero N, et al. Biochemistry of peroxynitrite and protein tyrosine nitration. Chem Rev. 2018; 118(3): 1338-408. https://doi.org/10.1021/acs.chemrev.7b00568.
Saed HHM, Ali ZA. Evaluating of some serum biochemical parameters in thyroid dysfunction women in Kalar’s General Hospital. Zanco J Pure Appl Sci. 2017; 29: 128-38. https://doi.org/10.21271/zjpas.29.s4.15.
Martemucci G, Costagliola C, Mariano M, D’andrea L, Napolitano P, D’Alessandro AG. Free Radical Properties, Source and Targets, Antioxidant Consumption and Health. Oxygen. 2022; 2(2): 48-78. https://doi.org/10.3390/oxygen2020006.
Duarte-Jurado AP, Gopar-Cuevas Y, Saucedo-Cardenas O, Loera-Arias MdJ, Montes-de-Oca-Luna R, Garcia-Garcia A, et al. Antioxidant therapeutics in Parkinson’s disease: current challenges and opportunities. Antioxidants (Basel). 2021; 10(3): 453. https://doi.org/10.3390/antiox10030453.
Esse R, Barroso M, Tavares de Almeida I, Castro R. The contribution of homocysteine metabolism disruption to endothelial dysfunction: state-of-the-art. Int J Mol Sci. 2019; 20(4): 867. https://doi.org/10.3390/ijms20040867.
Azzini E, Ruggeri S, Polito A. Homocysteine: its possible emerging role in at-risk population groups. Int J Mol Sci. 2020; 21(4): 1421. https://doi.org/10.3390/ijms21041421.
Liu N, Xu H, Sun Q, Yu X, Chen W, Wei H, et al. The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors. Oxid Med Cell Longev. 2021; 2021. https://doi.org/10.1155/2021/1470380.
Mahmood HG, Ali ZA, Abdulhameed RA, Hussein IM. Oxidative Stress and Total Antioxidant Capacity in Rheumatoid Arthritis. J Fac Med Baghdad. 2014; 56(3): 329-33. https://doi.org/10.32007/jfacmedbagdad.563528.
Wang Q, Wen X, Kong J. Recent progress on uric acid detection: a review. Crit Rev Anal Chem. 2020; 50(4): 359-75. https://doi.org/10.1080/10408347.2019.1637711.
Salwa HA-R, Abass KA-M. An evaluation of antioxidants and oxidative stress in Iraqi patients with thyroid gland dysfunction. Afr J Biochem Res 2011; 5(7): 188- 96.
Thabit MA, Abdullah GH, AL-Rawi KF. Polymorphism study of MTHFR 677C→ T and its correlation with oxidative stress and their influence on female infertility in Erbil–Iraq. Baghdad Sci J. 2017; 14(3): 611-618. http://dx.doi.org/10.21123/bsj.2017.14.3.0611.
Humaish HH. Study the antioxidant effect of tomato extract in oxidative stressed rats. Bas J Vet Res. 2016; 15(1): 66-80. http://dx.doi.org/10.33762/bvetr.2016.124255.
Phuadraksa T, Chittrakanwong J, Tullayaprayouch K, Onsirisakul N, Wichit S, Yainoy S. Engineering of Bifunctional Enzymes with Uricase and Peroxidase Activities for Simple and Rapid Quantification of Uric Acid in Biological Samples. Catalysts. 2020; 10(4): 428. https://doi.org/10.3390/catal10040428.
Maurya RP, Prajapat MK, Singh VP, Roy M, Todi R, Bosak S, et al. Serum malondialdehyde as a biomarker of oxidative stress in patients with primary ocular carcinoma: impact on response to chemotherapy. Clin Ophthalmol. 2021; 15: 871. https://doi.org/10.2147/opth.s287747.
Rasool M, Farooq S, Malik A, Shaukat A, Manan A, Asif M, et al. Assessment of circulating biochemical markers and antioxidative status in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) patients. Saudi J Biol Sci. 2015; 22(1): 106-11. https://doi.org/10.1016/j.sjbs.2014.09.002.
Hlavackova A, Vydra J, Chrastinova L, Kotlin R, Stikarova J, Suttnar J, et al. Alteration of serum malondialdehyde level as biomarker of oxidative stress during acute myeloid Leukemia treatment. Blood. 2019; 134: 5181. https://doi.org/10.1182/blood-2019-122303.
Esfahani A, Ghoreishi Z, Nikanfar A, Sanaat Z, Ghorbanihaghjo A. Influence of chemotherapy on the lipid peroxidation and antioxidant status in patients with acute myeloid leukemia. Acta Med Iran. 2012: 454-8.
Al-Wihaly BH, Al-Elawy AI, Al-Ubadiy GH, Al-Rubaie ZM. The Effect of Some Polyphenolic compounds on Serum Peroxynitrite of Leukemics. J Res Diala Humanit. 2009(39): 242-8.
Begum R, Bhuiyan M, Ferdoushi S, Rahim K, Adhikari D, Rahman S, et al. Raised Serum Homocysteine Level is Associated with Coronary Artery Disease in Young Patients. Arch Clin Biomed Res. 2022; 6(3): 575-86. https://doi.org/10.26502/acbr.50170268.
Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015; 14(1): 1-10. https://doi.org/10.1186/1475-2891-14-6.
Han K, Lu Q, Zhu W, Wang T, Du Y, Bai L. Correlations of degree of coronary artery stenosis with blood lipid, CRP, Hcy, GGT, SCD36 and fibrinogen levels in elderly patients with coronary heart disease. Eur Rev Med Pharmacol Sci. 2019; 23(21): 9582-9. https://doi.org/10.26355/eurrev_201911_19453.
Hasan T, Arora R, Bansal AK, Bhattacharya R, Sharma GS, Singh LR. Disturbed homocysteine metabolism is associated with cancer. Exp Mol Med. 2019; 51(2): 1-13. https://doi.org/10.1038/s12276-019-0216-4.
Shacter E, Williams JA, Hinson RM, Sentürker S, Lee Y-j. Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis. Blood, J Am Soc Hematol. 2000; 96(1): 307-13. https://doi.org/10.1182/blood.V96.1.307.
Rehman T, Shabbir MA, Inam‐Ur‐Raheem M, Manzoor MF, Ahmad N, Liu ZW, et al. Cysteine and homocysteine as biomarker of various diseases. Food Sci Nutr. 2020; 8(9): 4696-707. https://doi.org/10.1002/fsn3.1818.
Jumaah HM, Yenzeel JH, Mehdi MG. Evaluation of Some Biochemical Parameters and Hormones In Patients with Acute Myeloid Leukemia in Iraq. Iraqi J Sci. 2021: 1460-6. https://doi.org/10.24996/ijs.2021.62.5.9.
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