Designing and implementing a portable ultrasound bone densitometer

Authors

  • Saleh Massoud Faculty of Biomedical Engineering, Al-Andalus University for Medical Sciences, Tartous, Syria.
  • Mohammad Ruqiah Faculty of Biomedical Engineering, Al-Andalus University for Medical Sciences, Tartous, Syria. https://orcid.org/0009-0001-3473-1819
  • Ebrahim Ismaiel Faculty of Biomedical Engineering, Al-Andalus University for Medical Sciences, Tartous, Syria. https://orcid.org/0000-0003-4139-9639
  • Ahmad S. Ahmad Faculty of Biomedical Engineering, Al-Andalus University for Medical Sciences, Tartous, Syria. https://orcid.org/0009-0004-7137-7603
  • Fadi Motawej Mechatronics Engineering, Faculty of Engineering, Manara University, Latakia, Syria. https://orcid.org/0000-0003-3819-8801

DOI:

https://doi.org/10.21123/bsj.2023.8539

Keywords:

Arduino, Bone Mineral Density, Osteoporosis, Portable densitometer, Ultrasound

Abstract

Osteoporosis is a disease characterized by a low bone mass that increases the risk of fracture. The dual energy X-ray absorptiometry (DXA) bone densitometer is considered as the gold standard to measure bone mineral density (BMD). In Syria, the DXA is costly, not widely available and coupled with a strong reluctance among patients concerning exposure to ionizing radiation. On the other hand, several recent studies found that Quantitative Ultrasound (QUS) is useful in diagnosing osteoporosis and giving accurate information about the qualities of bone.  This study aims to design and implement a portable ultrasound bone densitometry to measure BMD. The device is portable (0.4 kg), much less expensive and does not have any harmful effect of ionizing radiation. The device contains a pair of ultrasound transducers HC-SR04 to send and receive ultrasound waves through the bone. The received signals were amplified and digitally recorded using the Arduino platform. The device was designed using a pre-designed model using CAD software, with wild range motion so it could be appropriate for many patients of different ages. The device was tested on many healthy individuals and patients of different sexes, aged 18–85 years, and also calibrated and validated with a known BMD value supplied by the DXA bone densitometer. The results demonstrated that our device is sensitive enough to distinguish between healthy and patient individuals by using low-cost instruments. Accordingly, the proposed device may have a good opportunity in the future to be considered an effective low-cost portable bone densitometer.

References

Aibar-Almazán A, Voltes-Martínez A, Castellote-Caballero Y, Afanador-Restrepo DF, Carcelén-Fraile MDC, López-Ruiz E. Current status of the diagnosis and management of osteoporosis. Int J Mol Sci. 2022; 23(16): 9465. https://doi.org/10.3390/ijms23169465

Maalouf G, Gannagé-Yared MH, Ezzedine J, Larijani B, Badawi S, Rached A, et al. Middle East and North Africa consensus on osteoporosis. JMNI - 2007; 7(2): 131. https://www.ismni.org/jmni/pdf/28/05MAALOUF.pdf

Bakir MA, Hammad KB, Habil KM. Bone mineral density in healthy Syrian women measured by dual energyX-ray absorptiometry. Anthropol Rev. 2018; 81(1): 18-28. http://dx.doi.org/10.2478/anre-2018-0002

Xie Q, Chen Y, Hu Y, Zeng F, Wang P, Xu L, et al. Development and validation of a machine learning-derived radiomics model for diagnosis of osteoporosis and osteopenia using quantitative computed tomography. BMC Med Imaging. 2022; 22(1): 1-9. https://doi.org/10.1186/s12880-022-00868-5 .

Theander L, Willim M, Nilsson JÅ, Karlsson M, Åkesson KE, Jacobsson LT, et al. Changes in bone mineral density over 10 years in patients with early rheumatoid arthritis. RMD open. 2020; 6(1): e001142. http://dx.doi.org/10.1136/rmdopen-2019-001142

Lyons-Reid J, Kenealy T, Albert BB, Ward KA, Harvey N, Godfrey KM, et al. Cross-calibration of two dual-energy X-ray absorptiometry devices for the measurement of body composition in young children. Sci Rep. 2022; 12(1): 13862. https://doi.org/10.1038/s41598-022-17711-0

Sweileh WM, Al-Jabi SW, Zyoud SE, Sawalha AF, Ghanim MA. Osteoporosis is a neglected health priority in Arab World: a comparative bibliometric analysis. Springerplus. 2014; 3: 1-7. https://doi.org/10.1186%2F2193-1801-3-427

Laugier P. Instrumentation for in vivo ultrasonic characterization of bone strength. IEEE Trans Ultrason Ferroelectr Freq Control. 2008; 55(6): 1179-96. https://doi.org/10.1109/tuffc.2008.782

Krieg MA, Barkmann R, Gonnelli S, Stewart A, Bauer DC, Barquero LD, et al. Quantitative ultrasound in the management of osteoporosis: the 2007 ISCD Official Positions. J Clin Densitom. 2008; 11(1): 163-87. https://doi.org/10.1016/j.jocd.2007.12.011

Grimal Q, Laugier P. Quantitative ultrasound assessment of cortical bone properties beyond bone mineral density. IRBM. 2019; 40(1): 16-24. https://doi.org/10.1016/j.irbm.2018.10.006

Bennett JE, Austin TM, Hayes AM, Reinking MF. Analysis of Calcaneal Bone Mineral Density (cBMD) in Healthy College Students. Int J Sports Phys Ther. 2022; 17(2): 218. https://doi.org/10.26603/001c.31653

Roberts JA, Shen Y, Strehlau R, Patel F, Kuhn L, Coovadia A, et al. Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV. Plos one. 2022; 17(10): e0276290. https://doi.org/10.1371/journal.pone.0276290

Ghani RF, Hassan HS. Human computer interface for wheelchair movement. Baghdad Sci J. 2017; 14(2): 0437. https://doi.org/10.21123/bsj.2017.14.2.0437

American Bone Health. Understanding Bone Density Results, Your T-score and Z-score Explained. Data accessed: 25 Dec 2020. From website: https://americanbonehealth.org/bone-density/understanding-the-bone-density-t-score-and-z-score/

Kanis JA, McCloskey EV, Harvey NC, Johansson H, Leslie WD. Intervention thresholds and the diagnosis of osteoporosis. J Bone Miner Res. 2015; 30(10): 1747-53. https://doi.org/10.1002/jbmr.2531

Farhan LO, Taha EM, Farhan AM. A Case control study to determine Macrophage migration inhibitor, and N-telopeptides of type I bone collagen Levels in the sera of osteoporosis patients. Baghdad Sci J. 2022; 19(4): 0848. https://doi.org/10.21123/bsj.2022.19.4.0848

Bąk-Drabik K, Adamczyk P, Chobot A, Pluskiewicz W. Skeletal status assessed by quantitative ultrasound and dual-energy X-ray absorptiometry in children with inflammatory bowel disease: A 2-year prospective study. Clin Res Hepatol Gastroenterol. 2020; 44(5): 768-77. https://doi.org/10.1016/j.clinre.2019.09.004

Downloads

Issue

Section

article

How to Cite

1.
Designing and implementing a portable ultrasound bone densitometer. Baghdad Sci.J [Internet]. [cited 2024 Apr. 30];21(5). Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8539