Mixed ligand complex: Synthesis, characterization, and investigation of biomedical activity
DOI:
https://doi.org/10.21123/bsj.2024.8582Keywords:
Biomedical activity, Cu complex, Cysteine, Melatonin, Mixed ligands.Abstract
A new complex, CuCl2.2H2O (M), was synthesized to react with melatonin (L1) and one of the amino acids (L-cysteine, L2) in a mole ratio of (1:1:1) (M: L1:L2) to produce the metal complex. The synthesized complex was then characterized using spectral techniques including infrared (FT-IR), thermal analysis (TG), flame atomic absorption (AAS), micro elemental analysis (CHNS), melting point (m.p.) measurement, and determination of chloride. Octahedral geometry was proposed for the complex. The copper complex was paramagnetic and non-electrolyte. The synthesized complex was evaluated as an antibacterial and antifungal agent against Escherchia coli (G-) and Staphylococcus aureus (G+). fungus Candida. The results showed that the copper complex was more active in 10–3 M than the two ligands; the complex's anti-cancer properties were also evaluated and gave a good result in the test.
Received 12/02/2023,
Revised 06/09/2023,
Accepted 08/09/2023,
Published Online First 20/03/2024
References
Nesa SH, Nasira SS, Uddin N, Ashrafuzzaman M, Habib A, Rashid AM, et al. Mixed ligand complexes: Synthesis, characterization and antibacterial activity investigation. Int J Chem. 2020.; 8: 306-12. http://dx.doi.org/10.22271/chemi.2020.v8.i1d.8267.
Tigineh GT, Sitotaw G, Workie A, Abebe A. Synthesis, characterization and in vitro antibacterial studies on mixed ligand complexes of iron (III) based on 1, 10-phenanthroline. Bull Korean Chem Soc. 2021; 65(3): 203-8. https://doi.org/10.5012/jkcs.2021.65.3.203.
Mahmoud WA, Hassan ZM. Synthesis and spectral analysis of some metal ions complexes with mixed ligands of Schiff base and 1, 10-phenanthroline. Baghdad Sci J. 2017; 14(1): 135-147. http://dx.doi.org/10.21123/bsj.2017.14.1.0135.
Mihsen HH, Abass SK, Hassan ZM, Abass AK. Synthesis, Characterization and Antimicrobial Activities of Mixed Ligand Complexes of Fe (II), Co (II), Ni (II) and Cu (II) Ions Derived from Imine of Benzidine and o-phenylenediammine. Iraqi J Sci. 2020; 61(11): 2762-2775. https://doi.org/10.24996/ijs.2020.61.11.2.
Al-Wasidi AS, Naglah AM, Refat M, El-Megharbel SM, Kalmouch A, Moustafa GO. Synthesis, spectroscopic characterization and antimicrobial studies of Mn (II), Co (II), Ni (II), Cr (III) and Fe (III) melatonin drug complexes. Egypt J Chem. 2020; 63(4): 1469-1481. https://doi.org/10.21608/ejchem.2020.21193.2263.
Sahib SK, Karem LK. Some metal ions complexes derived from Schiff base ligand with anthranillic acid: preparation, spectroscopic and biological studies. Baghdad Sci.J. 2020; 17(1): 99-105. http://doi.org/10.21123/bsj.2020.17.1.0099.
Hasan HR, Zainulabdeen JA. Screening, Extraction, and Quantification of Melatonin in Waste of Some Plants. Iraqi J Sci. 2022; 63(5): 1874-1884. https://doi.org/10.24996/ijs.2022.63.5.2.
Asif M, Pervez A, Ahmad R. Role of melatonin and plant‐growth‐promoting rhizobacteria in the growth and development of plants. CLEAN–Soil Air Water. 2019; 4(6): 1800459. https://doi.org/10.1002/clen.201800459.
Arnao MB, Hernández-Ruiz J. Melatonin: a new plant hormone and/or a plant master regulator?. Trends Plant Sci. 2019; 24(1): 38-48. https://doi.org/10.1016/j.tplants.2018.10.010.
Li Y, Zhang J, Wan J, Liu A, Sun J. Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease. Biomed Pharmacother. 2020; 132: 110887. https://doi.org/10.1016/j.biopha.2020.110887.
Pérez-Lloret S, Cardinali DP. Melatonin as a chronobiotic and cytoprotective agent in Parkinson’s disease. Front Pharmacol. 2021; 12: 650597. https://doi.org/10.3389/fphar.2021.650597.
Rehman T, Shabbir MA, Inam‐Ur‐Raheem M, Manzoor MF, Ahmad N, Liu ZW, et al. Cysteine and homocysteine as biomarker of various diseases. Food Sci Nutr. 2020; 8(9): 4696-707. https://doi.org/10.1002/fsn3.1818.
Daher B, Vučetić M, Pouysségur J. Cysteine depletion, a key action to challenge cancer cells to ferroptotic cell death. Front Oncol. 2020; 10: 723. https://doi.org/10.3389/fonc.2020.00723.
Bak D, Bechtel T, Falco J, Weerapana, E. Cysteine reactivity across the subcellular universe. Curr Opin Chem Biol. 2019; 48: 96– 105. https://doi.org/10.1016/j.cbpa.2018.11.002.
Nabavi SM, Silva AS. Nonvitamin and nonmineral nutritional supplements. Academic Press. 2018 Sep 28; Jan 1: 53-58. https://doi.org/10.1016/B978-0-12-812491-8.00007-2.
Jassim SA, Khaleel AM. Characterization and synthesis of new Schiff base compound from levofloxacin and L-cysteine with its Cu(II) and Pt(IV) complexes and estimation antibacterial and antifungal activities. Biochem. Cell Arch. 2021; 21(1): 2187-2195.
Papet I, Remond D, Dardevet D, Mosoni L, Polakof S, Peyron MA, Savary-Auzeloux I. Sulfur amino acids and skeletal muscle. InNutrition and skeletal muscle. Academic Press. 2019; 335-363. https://doi.org/10.1016/B978-0-12-810422-4.00020-8.
Junaid A, Ng CH, Ooi IH. Synthesis and Characterization of the Nanogold-Bound Ternary Copper (II) Complex of Phenanthroline and Cysteine as Potential Anticancer Agents. ACS omega. 2022; 7(30): 26190-26200. https://doi.org/10.1021/acsomega.2c01858.
Al-Abdali BI, Shakir IM, Nafea HM. Synthesis and Spectroscopic Studies of Some transition metal Complexes with Mixed ligand of Metformin and Cysteine. Iraqi J Sci. 2015; 56(4B): 3036-3047.
Abd El‐Halim HF., Mohamed GG, Anwar MN. Antimicrobial and anticancer activities of Schiff base ligand and its transition metal mixed ligand complexes with heterocyclic base. Appl Organomet Chem. 2018; 32(1): 3899. https://doi.org/10.1002/aoc.3899.
Abdul-Ghani AJ, Khaleel A. Synthesis and characterization of new schiff bases derived from N (1)-substituted isatin with dithiooxamide and their co (II), Ni (II), Cu (II), Pd (II), and Pt (IV) complexes. Bioinorg Chem Appl. 2009. https://doi.org/10.1155/2009/413175.
Kim H, Tse Y, Webb A, Mudd E, Abedin MR, Mormile M, Dutta S, Rege K, Barua S. PolyRad–Protection Against Free Radical Damage. Sci Rep. 2020; 10(1): 8335. https://doi.org/10.1038/s41598-020-65247-y.
Al-Jebouri GS, Noori AM. synthesis of New Boron Compounds with Amoxicillin and Some of Its Metal Complexes with Use Them in Antibacterial, Assessment of Hepatoprotictive and Kidneyactivity. Anticancer and Antioxidant Applications. Asian J Pharm Clin Res. 2019; 12(1-9). https://doi.org/10.22159/ajpcr.2019.v12i3.30912.
OMER RA, Koparir P, Ahmed L, Koparir M. Computational and spectroscopy study of melatonin. Indian J Chem Sect B. 2021; 60(5): 732-41.
https://doi.org/10.56042/ijcb.v60i5.40996.
Abdul-Ghani AJ, Khaleel A. Synthesis and characterization of new schiff bases derived from N (1)-substituted isatin with dithiooxamide and their co (II), Ni (II), Cu (II), Pd (II), and Pt (IV) complexes. Bioinorg Chem Appl. 2009;2009. https://doi.org/10.1155/2009/413175.
Freshney RI. Culture of animal cells: a manual of basic technique and specialized applications. John Wiley & Sons. 2015. https://doi.org/10.1002/9780470649367.
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