The Effectiveness of Calcium Supplement as Orally Contrast Media for Gastric Magnetic Resonance Imaging

Authors

  • Zainab Abdulla Mankhi Department of Medical Physics, College of Applied Medical Science, University of Kerbala, Karbala, Iraq. https://orcid.org/0000-0002-3733-3330
  • Khalid Ibrahim Riah Department of Physiology and Medical Physics, College of Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq. https://orcid.org/0000-0002-3222-0353
  • Ahmed Mehmood Abdul-Lettif Department of Physics, College of Science, University of Kerbala, Karbala, Iraq. https://orcid.org/0009-0008-9840-5781

DOI:

https://doi.org/10.21123/bsj.2024.9053

Keywords:

Contrast agent, Contrast media, Magnetic Resonance Imaging, Oral contrast agent, Safe contrast agent

Abstract

The objective of the present work aims to find an alternative oral contrast agent that could be used in magnetic resonance imaging (MRI) of the gastrointestinal system and satisfy the following criteria: it should be safe, it has no or few side effects, it is inexpensive, and it produces the highest imaging quality. The method: We prepared samples (solutions) as oral contrast agents by separately dissolving calcium and magnesium supplements (taken daily dose) in varied quantities of distilled water. In order to identify the sample with the lowest concentration and best quantitative image, the samples were examined in MRI by phantoms. After that, the best sample was tested by ten healthy individuals. The image result is measured by the signal value to calculate signal to-noise-ratio (SNR), relative signal to noise ratios (RSN) and contrast (C) and then a different test is performed. There were significant variations in stomach signal values between pre and post contrast (p-value 0,05). The results: The results showed that the magnesium supplement has essentially no effect on the water signal intensity in T1-weighted and T2-weighted, whereas the calcium supplement enhances the signal intensity of the water in T2-weighted. The conclusion: The magnesium mineral solution with all concentrations has relatively little impact on the water's hydrogen signal, making it impossible to distinguish this impact with the naked eye. Therefore, it is neglected in the clinical study.  The calcium supplement can be employed as a positive contrast agent on T2-weighted images for gastrointestinal imaging

References

Panayides AS, Amini A, Filipovic ND, Sharma A, Tsaftaris SA, Young A, et al. AI in medical imaging informatics: current challenges and future directions. IEEE J Biomed Health Inform. 2020; 24(7):1837-57. https://dx.doi.org/10.1109/JBHI.2020.2991043

Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, et al. Guidelines for the management of pediatric severe traumatic brain injury: update of the brain trauma foundation guidelines. Pediatr Crit Care Med. 2019; 20(3S):S1-82. https://dx.doi.org/10.1093/neuros/nyz051

Wahsner J, Gale EM, Rodríguez-Rodríguez A, Caravan P. Chemistry of MRI contrast agents: current challenges and new frontiers. Chem Rev. 2018;119(2):957-1057. https://dx.doi.org/10.1021/acs.chemrev.8b00363

Lux J, Sherry AD. Advances in gadolinium-based MRI contrast agent designs for monitoring biological processes in vivo. Curr Res Chem Biol. 2018; 45:121-30. https://dx.doi.org/10.1016/j.cbpa.2018.04.006

Biondi M, Bicci E, Danti G, Flammia F, Chiti G, Palumbo P, et al. The role of magnetic resonance enterography in Crohn’s disease: a review of recent literature. Diagnostics (Basel). 2022;12(5):1236. https://dx.doi.org/10.3390/diagnostics12051236

Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P. A manganese-based alternative to gadolinium: contrast-enhanced MR angiography, excretion, pharmacokinetics, and metabolism. Radiology. 2018;286(3):865. https://dx.doi.org/10.1148/radiol.2017170977

Mauri M, Collico V, Morelli L, Das P, Garcia I, Penaranda A J, et al. MnO Nanoparticles Embedded in Functional Polymers as T 1 Contrast Agents for Magnetic Resonance Imaging. ACS Appl. Nano Mater. 2020;3(4):3787-97. https://dx.doi.org/10.1021/acsanm.0c00474

Radhi MM, Al-Shimmari HA, Al-Mulla EA, Abdullah AA, Wadday AG. New voltammetric study of MgCl2 as alternative contrast media in MRI molecular imaging. Nano Biomed. Eng. 2017;9(2):152-61.https://dx.doi.org/10.5101/nbe.v9i2.p152-161

Mustafa DA, Al-Shimmari HA, Radhi MM. Use of MgCl2 Nanoparticles as Alternative Contrast Media in Magnatic Resonance Imaging Molecular Imaging and Analyzed by Voltammetric Technique. Nano Biomed. Eng. 2020;12(2):148-52. https://dx.doi.org/10.5101/nbe.v12i2.p148-152

Yang H, Wang H, Wen C, Bai S, Wei P, Xu B, et al. Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice. J Nanobiotechnology. 2022;20(1):1-8. https://dx.doi.org/10.1186/s12951-022-01291-2

Isnoviasih ST, Anwar MC, Indrati R, Wibowo GM, Masrochah S. Iron supplements in suppressing gastric Signal on MRCP. Int. j. allied ed. sci. clin. res. 2019 ;(3): 784-788. https://dx.doi.org/10.1177/2058460117727315

Kaunzner UW, Gauthier SA. MRI in the assessment and monitoring of multiple sclerosis: an update on best practice. Ther Adv Neurol Disord. 2017;10(6):247-61. https://dx.doi.org/10.1177/1756285617708911

Yang X, Lovell JF, Zhang Y. Ingestible contrast agents for gastrointestinal imaging. Bio. Chem. 2019 ;20(4):462-73.https://dx.doi.org/10.1002/cbic.201800589

Utami HS, Mulyantoro DK, Fatimah F. Jasmine tea as a negative oral contrast agent in magnetic resonance cholangiopancreatography (MRCP). J Phys Conf Ser .2021 :1943 (1): 012039. https://dx.doi.org/10.1088/1742-6596/1943/1/012039

Pohmann R, Speck O, Scheffler K. Signal‐to‐noise ratio and MR tissue parameters in human brain imaging at 3, 7, and 9.4 tesla using current receive coil arrays. Magn Reson Med. 2016;75(2):801-9. https://dx.doi.org/10.1002/mrm.25677

Raed MK, HussienAA. Estimation of Radiation Dose from Most Common Pediatrics Radiographic Examinations within Main Central Hospitals in Najaf City, Iraq. Baghdad Sci J. 2022; 19 (3): 654-659. https://dx.doi.org/10.21123/bsj.2022.19.3.0654

Naji NA. Assessment of image quality of cervical spine complications using Three Magnetic Resonance Imaging Sequences. Baghdad Sci J. 2023 Jun 20;20(3 (Suppl.)): 1155-. https://dx.doi.org/10.21123/bsj.2023.8244

Stea TH, Lillegaard IT, Froyland L, Haugen M, Henjum S, Løvik M, et al. Assessment of dietary intake of nicotinic acid and nicotinamide in relation to tolerable upper intake levels. Nutr. Rev. 2017: 27: 1-38. https://dx.doi.org/10.1093/nutrit/nux011

Downloads

Published

2024-10-01

Issue

Section

article

How to Cite

1.
The Effectiveness of Calcium Supplement as Orally Contrast Media for Gastric Magnetic Resonance Imaging. Baghdad Sci.J [Internet]. 2024 Oct. 1 [cited 2024 Dec. 4];21(10):3248. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9053

Similar Articles

You may also start an advanced similarity search for this article.