Synthesis and Description of Some New Heterocyclic Imideis Compounds Derived from Ciprofloxacin Drug
DOI:
https://doi.org/10.21123/bsj.2024.9222Keywords:
2-Aminobenzothiazole derivatives, Biological activities, Ciprofloxacin drug, Heterocyclic compounds, Imide derivatives.Abstract
The target of this work included synthesis of several new derivatives (B-B17) from Ciprofloxacin drug and evaluating antibacterial activities for some derivatives. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The first step involved the preparation of a 2-Chloroacetyl Ciprofloxacin drug from the reaction of Ciprofloxacin with chloroacetyl chloride in the presence of triethylamine. Then, the yield B with 2-aminobenzothiazole in the presence of glacial acetic acid as a catalyst to produce derivatives (B1-B8), Potassium phthalimide or Succinimide was used to prepared (B9-B12) compounds , and the (B13-B17) compounds were synthesis from 4-acetyl ciprofloxacin (B).The antibacterial and antifungal activity showed effectiveness against Gram-positive bacteria (Staphylococcus), Gram-negative bacteria (Pseudomonas aeruginosa), and fungi (Candida Albicans).
Received 11/06/2023
Revised 15/03/2023
Accepted 17/03/2023
Published Online First 20/07/2024
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