Simultaneous Determination of Lisinopril and Amlodipine Using Third Derivative Spectroscopy
DOI:
https://doi.org/10.21123/bsj.2024.9893Keywords:
Amlodipine, Combined formulation, Lisinopril, Third derivative spectroscopy, Zero-crossing point.Abstract
In the present investigation, the simultaneous determination of lisinopril and amlodipine in their pure forms and in pharmaceutical formulations were determined using third derivative spectrophotometry. The process is easy, precise, accurate, and economical. The medications in the combined formulation were analyzed using the zero-crossing point method. Lisinopril and amlodipine were discovered to have wavelengths of (204 and 240 nm) and (248 and 272 nm), respectively, in solvent medium in a concentration range of 5–45 µg mL-1 for lisinopril and 5–40 µg mL-1 for amlodipine. The results were much in line with the accepted methodology. Common tablet excipients showed no interference. the recovery rate of lisinopril dihydrate was 98.57 to 103.42% and amlodipine 95.14 to 102.80%. Amlodipine besylate and lisinopril dihydrate were satisfactorily measured using this technique in tablet forms.
Received 08/10/2023
Revised 26/01/2024
Accepted 28/01/2024
Published Online First 20/11/2024
References
Ali DK, Fakhre NA, Rasheed CM. Simultaneous Determination of Binary Mixture of Estradiol and Progesterone Using Different Spectrophotometric Methods. Baghdad Sci J. 2023; 20(6): 2193-2206. https://dx.doi.org/10.21123/bsj.2023.7822
Alsamarrai HA, Alsamarrai KF. Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy. Baghdad Sci J. 2017 Jun. 4; 14(2): 0320-7. https://doi.org/10.21123/bsj.2017.14.2.0320
Gao Y, Zhou D, Yang P. Effect of amlodipine on ventricular hypertrophy in hypertension patients: a systematic review and meta-analysis. Ann Palliat Med. 2021 Oct; 10(10): 107680778-10778. https://doi.org/10.21037/apm-21-2455.
Sofy AA, Abdelsattar AT, Mohammed OM, Shareef MA, Alamodi AA, Nso N, et al. Amlodipine compared with benidipine in the management of hypertension: a systematic review and meta-analysis. High Blood Press Cardiovasc Prev. 2020 Dec; 27: 527-37. https://doi.org/10.1007/s40292-020-00412-y
Afroz F, Sharmin S, Rony SR, Moni F, Sohrab MH. Quality and Pharmaceutical Equivalence Determinations of Commercially Available Amlodipine Besylate Immediate Release Tablets. J Pharm Pharmacol. 2022 May 24; 13(5): 129-39. https://doi.org/10.4236/pp.2022.135010.
Galeeva ZM, Galiavich AS. A fixed dose lisinopril and amlodipine combination in conjunction with rosuvastatin in patients with hypertensive disease and coronary heart disease. Ter arkh. 2014 Sep 15; 86(9): 71-76.
Li T, Liu YP, Liu SQ, Shi P, Jiang X, Tao Y, et al. Bioequivalence evaluation and food effect assessment of Lisinopril/amlodipine tablets in healthy Chinese subjects under fasting and fed conditions. BMC Pharmacol Toxicol. 2022 Jul 7; 23(1): 45. https://doi.org/10.1186/s40360-022-00590-6.
Bozhanov S, Smerikarova M, Maslarska V. Quantitative determination of Lisinopril Dihydrate in pharmaceutical preparations by direct potentiometriy. IOP Conf Ser: mater Sci Eng 2020 7291; 1: 012059. IOP Publishing. https://doi.org/10.1088/1757-899X/729/1/012059
Sri KB. Ultraviolet–visible Spectrophotometric and Titration Method for the Assay of Lisinopril Bulk and Pharmaceutical Dosage Form. Int J Phram Sci Clin Res. 2022 Dec 15; 2(4): 134-138. https://doi.org/10.22377/ijpscr.v2i4.112
Babar SA, Padwal SL, Bachute MT. Qbd based RP-HPLC method development and validation for simultaneous estimation of amlodipine besylate and lisinopril dihydrate in bulk and pharmaceutical dosage form. J Pharm Res Int. 2021; 33(43A): 143-164. https//doi.org/10.9734/jpri/2021/v33i43A32474
Piponski M, Stoimenova TB, Serafimovska GT, Stefova M. Development and validation of fast, simple, cost-effective and robust RP-HPLC method for simultaneous determination of lisinopril and amlodipine in tablets. Anal Chem Let. 2019 May 4; 9(3): 385-402. https://doi.org/10.1080/22297928.2019.1650108
Attimarad M, Venugopala KN, SreeHarsha N, Aldhubiab BE, Nair AB. Validation of rapid RP-HPLC method for concurrent quantification of amlodipine and celecoxib in pure and formulation using an experimental design. Microchem j. 2020 Jan 1; 152: 104365. https://doi.org/10.1016/j.microc.2019.104365
Fahelelbom K, Al-Tabakha MM, Eissa NA, Obaid DE, Sayed S. Development and Validation of an RP-HPLC Analytical Method for Determination of Lisinopril in Full and Split Tablets. Research J Pharm Technol. 2020; 13(6): 2647-2652. https://doi.org/10.5958/0974-360X.2020.00470.9
Shah DA, Patel DV, Mehta FA, Chhalotiya UK, Bhatt KK. High-performance thin-layer chromatography method for estimating the stability of a combination of irbesartan and amlodipine besylate. J Taibah Univ Sci. 2015 Apr 1; 9(2): 177-186. https://doi.org/10.1016/j.jtusci.2014.07.007
Chaudhary BR, Dave JB. Estimation of telmisartan, amlodipine and chlorthalidone in bulk and fixed dose combination using stability indicating high performance thin layer chromatography. Indo Global J Pharm Sci. 2020; 10(3): 6-20.https://doi.org/10.35652/IGJPS.2020.10302
Ahmed AM, Tapabashi NO, Allah NM. Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1-sulfonic acid Reagent. Tikrit J Pure Sci. 2021; 26(1): 46-52. https://doi.org/10.25130/tjps.v26i1.98
Siridevi MP, Hemant KT, Srinivasa RY, Varaprasad RK. Simultaneous Spectrophotometric Estimation of amlodipine besylate and Perindopril Erbumine in tablet Formulation. Res J Pharm Technol. 2019; 12(12): 6101-6106.https://doi.org/10.5958/0974-360X.2019.01060.6
Mohammed FF, Badr El-Din K, Derayea SM. Two smart spectrophotometric methods for simultaneous determination of Lisinopril and Hydrochlorothiazide in binary mixtures. J adv Biomed Pharm Sci. 2019 Apr 1; 2(2): 47-53. http://doi.org/10.21608/jabps.2019.6766.1031
Shulyak N, Budzivula K, Kucher T, Kryskiw L, Poliak O, Logoyda L. Spectrophotometric methods for the determination of lisinopril in medicines. Pharmacia. 2021 Oct 18; 68(4): 811-818. https://doi.org/10.3897/pharmacia.68.e72991
Prasad CV, Saha RN, Parimoo P. Simultaneous Determination of Amlodipine‐Enalapril Maleate and Amlodipine‐Lisinopril in Combined Tablet Preparations by Derivative Spectrophotometry. Pharm Pharmacol commun. 1999; 5(6): 383-388.https://dx.doi.org/10.1211/146080899128735027.
Nasr JJ, Shalan S. Simultaneous estimation of amlodipine and atorvastatin by micelle-augmented first derivative synchronous spectrofluorimetry and multivariate analysis. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 5; 224: 117430. http://doi.org/10.1016/j.saa.2019.117430
Nejres AM, Najem MA. Simultaneous determination of amlodipine and lisinopril dihydrate using fourth derivative spectroscopy. Eur J Chem. 2023 Mar 31; 14(1): 65-71. https://doi.org/10.5155/eurjchem.14.1.65-71.2367
Patel HB, Patel BA, Parmar SJ. Development and validation of second order derivative spectrophotometric method for simultaneous estimation of Atenolol and Nifedipine in combined dosage form. Intl J Pharm Sci Res 2013; 4(10): 3884-3888.http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3884-88.
Attala K, Eissa MS, Hasan MA, El-Henawee MM, Abd El-Hay SS. An enhanced first derivative synchronous spectrofluorimetric method for determination of the newly co-formulated drugs, amlodipine and celecoxib in pharmaceutical preparation and human plasma. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Oct 15; 240: 118533.https://doi.org/10.1016/j.saa.2020.118533.
Ermer J, Miller JH, editors. Method validation in pharmaceutical analysis: A guide to best practice. 2nd edition John Wiley & Sons, UK; 2006 Mar 6. https://doi.org/10.1002/9783527672202
Downloads
Issue
Section
License
Copyright (c) 2024 hasan aldewachi
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
