تعدد الأشكال المترادفة المتعاقبة لمورث مضاد مستقبل الحريك الخلوي-1 و علاقته بالعقم عند الرجال في أربيل/كوردستان العراق
الشريط الجانبي للمقالة
محتوى المقالة الرئيسي
الملخص
عائلة الحريك الخلوي -1 لها أدوار متعددة في الجهاز التناسلي الذكري، ومن بينها مضادات مستقبلات الحريك الخلوي -1 (IL-1RN) الموجودة في الغدد التناسلية الذكرية، حيث تزداد نشاطها عند الاصابات بالعدوى والالتهاب. تهدف الدراسة الحالية إلى التحقق من وجود صلة محتملة لتعدد الأشكال المترادفة المترادفة (VNTR) للجين IL-1RN مع العقم عند الذكور. شملت مجموعات الدراسة المسجلين 100 من الرجال المصابين بالعقم و 100 من الرجال الأصحاء. حيث تم تحليل السوائل المنوية للمجموعات المشاركة. تم جمع عينات الدم المحيطي لتقييم أو الكشف عن تعدد الأشكال المترادفة المترادفة (VNTR) لجين مضادات مستقبلات الحريك الخلوي -1 (IL-1RN) لنمطين من الاليلاتأليل IL-1RN1 يتوافق مع 410 زوج قاعديIL-11RN2 يتوافق مع 240وج قاعدي كعلامة على العقم عند الذكور، باستخدام تقنية PCR حددت النتائج ارتفاع وتيرة التغاير الاليلي IL-1RN2 (26٪) ، واثنين من التغاير الاليلي VNTR ناقلات IL-1RN1 و IL-1RN2 (16٪) من الرجال المصابين بالعقم مع تأثيرات كبيرة على حركة الحيوانات المنوية واشكالها (P<0.000-0.002) على التوالي. هذه الدراسة التى تم تقييمها في إقليم كردستان (أربيل – العراق) والتى حددت تأثيراً كبيراً لتعدد الأشكال المترادفة المتعاقبة VNTR لجين IL-1RN في مسببات العقم عند الذكور خاصة على حركية الحيوانات المنوية واشكالها، ولا سيما ناقلات أليلية البديل IL-1RN2.
تفاصيل المقالة
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كيفية الاقتباس
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