تحضير و تحديد التركيب للمركب 6-O-بروب-2-نايل- 2،1: 4،3-ثنائي- O- أيزوبروبليدين- د-ألفا- جالاكتوز
DOI:
https://doi.org/10.21123/bsj.2022.6914الكلمات المفتاحية:
حسابات نظرية الكثافة الوظيفية، الجالاكتوز، إثيرات البروبارجيل, الألكينات الطرفيةالملخص
في هذا العمل، تم تحضير إثير ألكينيل سكر مهم في خطوتين متتاليتين بدءًا من سكر د-جالاكتوز المتاح تجاريًا. إن هذا النوع من المركبات يعد ذات أهمية في تحضير مركبات ذات فعالية حيوية مثل الترايازولات و الآيسوكسازولات. في الخطوة الأولى، تم تفاعل الجالاكتوز (3) مع الأسيتون في وجود كبريتات النحاس اللامائي (II) لإنتاج 2،1: 4،3-ثنائي- O- أيزوبروبليدين- د-ألفا- جالاكتوز (4) بمنتوج جيد. ثم تفاعل المركب الأخير مع زيادة من بروميد البروبارجيل في مذيب ثنائي مثيل فورمأمايد بوجود حبيبات هيدروكسيد الصوديوم لتعطي الجزيء المستهدف 5 في بمنتوج جيد جدًا. إن درجة حرارة هذه الخطوة تعد حاسمة في تحديد منتوج التفاعل. تم تحديد الوضعية الفراغية للمركب 5 بإستخدام تقنية الرنين المغناطيسي النووي وحسابات نظرية الكثافة الوظيفيةDFT .
Received 10/1/2022
Accepted 10/3/2022
Published Online First 20/7/2022
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