التحضير و الفعالية المضادة للسرطان و البكتريا لمشتقات ثنائي 3،2،1-تريازول مانوز

محتوى المقالة الرئيسي

لمياء صالح مهدي
https://orcid.org/0000-0002-1689-2432
عدنان إبراهيم محمد
ماجد جاري محمد

الملخص

            في العمل الحالي ، تم تحويل هاليدات الألكيل 1a‒b و الأمينات الأروماتية 3a‒b إلى الأزيدات المقابلة مرة عن مع أزيد الصوديوم في مذيب قطبي لا بروتوني لتعطي مشتقات الأزايد الأليفاتية 2a‒b و أخرى عن طريق التفاعل مع نتريت الصوديوم ومن ثم أزيد الصوديوم لتنتج الأزايدات الأروماتية 4a‒b. و في خطوة مقابلة حُضِر مشتق ثنائي بروبارجيل إيثر لـسكر المانوز 8 بدءً من مشتق مانوز ثنائي الأسيتون (7) الذي تم الحصول عليه عن طريق معاملة سكر المانوز (5) مع الأسيتون الجاف بوجود حمض الكبريتيك. بعد ذلك ، تم إستخدام تفاعل تكاثف الألدول لتحضير مشتق ثنائي الكحول 6 بدءً من ثنائي أسيتونيد مانوز 5. و من ثم فوعل المركب 3 مع بروميد بروبارجيل في وسط قلوي لينتج مشتق ثنائي بروبارجيل 8.  تضمنت الخطوة الأخيرة مفاعلة كل من مشتق ثنائي بروبارجيل 8 مع الأزيدات الأليفاتية 2a‒b أو الأروماتية 4a‒b للحصول على مشتقات ثنائي- 3،2،1-تريازول 9a‒b وبوجود أملاح النحاس الأحادية كعامل مساعد. تم تشخيص جميع المركبات المحضرة النهائية و عدد من المركبات الأولية بتقنيات  الرنين المغناطيسي النووي أحادي و ثنائي الأبعاد و كذلك بإستخدام طيف الكتلة عالي الدقة. تم تقييم فعالية المركبات المضادة للبكتيريا ضد كل من البكتيريا موجبة الجرام وسالبة الجرام و علاوة على ذلك تم تقييم الفعالية المضادة للمركبات المحضرة ضد سرطان الثدي (خط خلايا AMJ13) .

تفاصيل المقالة

كيفية الاقتباس
1.
التحضير و الفعالية المضادة للسرطان و البكتريا لمشتقات ثنائي 3،2،1-تريازول مانوز. Baghdad Sci.J [انترنت]. 1 أغسطس، 2023 [وثق 23 يناير، 2025];20(4):1309. موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7402
القسم
article

كيفية الاقتباس

1.
التحضير و الفعالية المضادة للسرطان و البكتريا لمشتقات ثنائي 3،2،1-تريازول مانوز. Baghdad Sci.J [انترنت]. 1 أغسطس، 2023 [وثق 23 يناير، 2025];20(4):1309. موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7402

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