تقدير مستوى ACE-2 وبعض المعلمات البيوكيميائية مع دراسة ثاثيره الجنس على مرضى السكري العراقين المصابين بتليف الكبيبات والنبيبات الكلوية كعلامة للتنبؤ المبكر
محتوى المقالة الرئيسي
الملخص
مرض الكلى السكري هو مرض يصيب الكبيبات ويتداخل مع حاجز الترشيح الكبيبي ) (GFB والذي يعمل على تمكين الكلى من التنقية الانتقائية للماء والمذابات بالإضافة إلى الحد من حركة الجزيئات الكبيرة مثل الألبومين . في البطانة الكبيبية ، والخلايا المسراق ، وخلايا القدم ، وحد الفرشاة للأنابيب القريبة ، يتم التعبير عن الإنزيم المحول للأنجيوتنسين 2 وأن الكلى تمثل المنطقة الأكثر تعبيرًا عن هذا الإنزيم. وبالتالي تهدف الدراسة الحالية إلى تقييم مستوى ACE-2 في هذه الحالة مقارنة بالحالة الصحية.اشتملت الدراسة على 120 ذكر وأنثى تتراوح أعمارهم بين (30-65) سنة. تم تقسيم تسعين مريضًا مصابًا بداء السكري من النوع 2 إلى ثلاث مجموعات على أساس معايير ACR تشمل البيلة الألبومينية الطبيعية والبيلة الألبومينية الدقيقة والبيلة الألبومينية الكبيرة (30 مريضًا لكل مجموعة) و 30 شخصًا يتمتعون بصحة جيدة كانوا بمثابة المجموعة الضابطة ، الذين زاروا مستشفى بغداد التعليمي / المدينة الطبية و مستشفى اليرموك التعليمي ، في الفترة ما بين ديسمبر 2021 ومايو 2022. تم تحديد مستويات ACE-2 باستخدام تقنية ELISA . اظهرت النتائج فروقات ذات دلالة ﺇ حصائية بين اعتلال االكلية السكري ومجموعة السيطرة في حالة الاناث .ولكن لاتوجد فروق ذات دلالة إحصائية في حالة الذكور تم الحصول على نتائج مماثلة في ايون البوتاسيوم كما أوضحت النتائج وجود فروق معنوية في أيون الصوديوم ، و ACR، و eGFR ، واليوريا ، و FBS ، والكرياتينين بين مجموعة اعتلال الكلية السكري والمجموعة الصحية. يمثل ACE-2 علامة جيدة للتنبؤ المبكر في حالة اعتلال الكلية السكري. عززت نتائج تحليل بيانات ROC أهمية ACE-2 في تشخيص حالة المرض المدروسة.
Received 16/9/2022, Revised 16/12/2022, Accepted 18/12/2022, Published Online First 20/4/2023
تفاصيل المقالة
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كيفية الاقتباس
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