دراسة الميوستاتين كمؤشر تشخيصي في امصال النساء العراقيات المصابات بمتلازمة التمثيل الغذائي
محتوى المقالة الرئيسي
الملخص
السمنة في منطقة البطن، ومقاومة الأنسولين ، وارتفاع السكر في الدم ، وعسر شحميات الدم ، وارتفاع ضغط الدم كلها جزء من متلازمة التمثيل الغذائي. تقوم الخلايا العضلية بتصنيع وإطلاق الميوكين المعروف باسمmyostatin ، والذي يعمل على خلايا العضلات لمنعها من النمو. كان الهدف من هذه الدراسة هو مقارنة مستويات الميوستاتين لدى الأشخاص الذين يعانون من متلازمة التمثيل الغذائي والذين لا يعانون منها. صممت الدراسة الحالية لمقارنة بعض المؤشرات الحيوية في امصال مرضى متلازمة الأيض والأشخاص الأصحاء من خلال تقدير الميوستاتين، نسبة السكر في الدم لدى الصائمين (FBS) ، الكوليسترول ، البروتين الدهني عالي الكثافة (HDL) ، الدهون الثلاثية (T.G) ، البروتين الشحمي منخفض الكثافة. (LDL) ، البروتين الدهني منخفض الكثافة (VLDL) ، في امصال المرضى العراقيين المصابين بمتلازمة التمثيل الغذائي والأشخاص الأصحاء. تم تقسيم ما مجموعة ثمانين امرأة إلى مجموعتين: المجموعة الأولى 40 مريض متلازمة ايضية والمجموعة الثانية 40 شخصًا سليما . أظهرت النتائج زيادة معنوية في مستويات الميوستاتين p> 0.001 في مجموعة متلازمة التمثيل الغذائي مقارنة بالمجموعة الضابطة. أظهر منحنى ROC لليموستاتين قيمة فاصلة واضحة (5) عند حسابه في متلازمة التمثيل الغذائي. وخلصت الدراسة إلى أن الميوستاتين هو عامل تشخيصي للميوستاتين.
Received 29/11/2022
Revised 10/02/2023
Accepted 12/02/2023
Published Online First 20/08/2023
تفاصيل المقالة
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كيفية الاقتباس
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