تصميم , تحضير , توصيف مجموعه جديدة من مشتقات ٣،٢- ثنائي هيدروكوينزولين -4 (1H) (DHQZ-1) وتقييم الفعالية المضادة للورم باستخدام الالتحام الجزيئي حاسوبيا

المؤلفون

  • Mohammed Abed Kadhim قسم الكيمياء، كلية العلوم، جامعة الانبار، الانبار، العراق. https://orcid.org/0000-0001-9096-7642
  • Emad Khelil Mohammed Zangana قسم الكيمياء ، كلية العلوم والصحة ، جامعة كوية ، كويه ، اربيل، العراق. https://orcid.org/0000-0002-7829-0437
  • Arkan Hassan Jawad مديرية تربية ذي قار ، ذي قار، العراق. https://orcid.org/0000-0003-4372-1513

DOI:

https://doi.org/10.21123/bsj.2023.8232

الكلمات المفتاحية:

مضاد للأورام )بروتين 1M17 ), 3,2- ديهيدروكوينازولين-4 (1H) واحد , (DHQZ-1) أنهيدريد إيزاتويك, تفاعلات متعددة المكونات , (MCRs) الالتحام الجزيئي بيريدين -3 كاربالديهايد

الملخص

الهدف من هذا البحث هو استخدام التفاعلات متعددة المكونات لإنتاج سلسلة جديدة من مشتقات  الكوينزولين والتي تعطي منتوج كثير.يحدث هذا التفاعل من خلال تكثيف بيريدين-3- كاربالديهايد  مع-1,3-H1 بنزاوكزازين-2و4-ثنائي ون )أيساتويك انهيدرايد) والأمينات الأولية (7-3). وتمت اذابه المكونات باستخدام مذيب رباعي هيدروالفوران (THF ، مذيب غير بروتوني) (البروتوني). مع كبريتات الصوديوم الهيدروجينيه (NaHSO4) على شكل عامل مساعد في التفاعل وذلك لتوفيرمنتوج عالي من مشتقات 2،3- ثنائي هيدروكوينزولين -4 (1H). تم الحصول على أفضل ناتج عند درجه حراره 68 درجة مئوية. بشكل عام ، تُظهر جميع المنتجات المتسلسلة (8-12) قدرة كبيرة كمضاد فعال لسرطان الثدي باستخدام دراسة الالتحام الجزيئي للمشتقات حيث اعطى المركب 11 ، اكثر فعالية مضادة من المركبات المحضرة الاخرى. تم تقييم دراسة الالتحام الجزيئي للمشتقات باستخدام برنامج تصميم الأدوية Auto Dock 4.2  . (PDB)) ، كود البروتين M171).

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كيفية الاقتباس

1.
تصميم , تحضير , توصيف مجموعه جديدة من مشتقات ٣،٢- ثنائي هيدروكوينزولين -4 (1H) (DHQZ-1) وتقييم الفعالية المضادة للورم باستخدام الالتحام الجزيئي حاسوبيا. Baghdad Sci.J [انترنت]. [وثق 21 مايو، 2024];21(7). موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8232