العلاقة بين سمية الفلوريد والإجهاد التأكسدي ومضاعفات الحمل لدى النساء اللواتي يعشن في مناطق التسمم بالفلور
محتوى المقالة الرئيسي
الملخص
كان الهدف من هذه الدراسة هو التحقيق من العلاقة بين مستويات فلوريد البلازما المرتفعة، والإجهاد التأكسدي، ومضاعفات الحمل (الإجهاض، وموت الجنين داخل الرحم، والولادة المبكرة، وتسمم الحمل) لدى النساء اللواتي يعشن في إقليم سطات بالمغرب. تم جمع عينات الدم من النساء الحوامل ذوات الحمل الطبيعي (عدد = 60)، والإجهاض (عدد = 20)، وموت الجنين داخل الرحم (عدد = 10)، والولادة المبكرة (عدد = 20)، وتسمم الحمل (عدد = 20). بعد ذلك، تم تحديد مستويات فلوريد البلازما والأنشطة الأنزيمية لخلايا الدم الحمراء من superoxide dismutase (SOD)، catalase (CAT)، glutathione peroxidase (GPx). أظهرت النتائج أن مستويات الفلوريد في البلازما أقل بشكل ملحوظ عند النساء ذوات الحمل الطبيعي بتركيز 0.030 ± 0.003 ملغم / لتر مقارنة بالنساء اللائي تعرضن للإجهاض وموت الجنين داخل الرحم والولادة المبكرة وتسمم الحمل، بتركيزات 0.040 ± 0.002، 0.037 ± 0.002، 0.034 ± 0.004 و0.034 ± 0.003 ملغم / لتر، على التوالي. بالإضافة إلى ذلك، زاد نشاط SOD بشكل ملحوظ عند النساء اللواتي يعانين من مضاعفات الحمل، بينما انخفضت أنشطة CAT وGPx مقارنة بالنساء ذوات الحمل الطبيعي. علاوة على ذلك، لوحظ وجود علاقة قوية بين مستويات فلوريد البلازما وأنشطة مضادات الأكسدة ومضاعفات الحمل. قد يؤدي وجود مستويات عالية من فلوريد البلازما إلى زيادة انتشار الإجهاض ووفاة الجنين داخل الرحم والولادة المبكرة وتسمم الحمل، عبر مسار الإجهاد التأكسدي لدى النساء الحوامل اللواتي يعشن في إقليم سطات بالمغرب.
Received 28/12/2022
Revised 20/06/2023
Accepted 22/06/2023
Published Online First 20/09/2023
تفاصيل المقالة
هذا العمل مرخص بموجب Creative Commons Attribution 4.0 International License.
كيفية الاقتباس
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