تقييم بعض انزيمات القلب والحديد في مصل مرضى بيتا-ثلاسيميا في مدينة ذي قار ، العراق

المؤلفون

  • Ahmed jaber ibrahim قسم علوم الكيمياء، كلية العلوم، جامعة البصرة، البصرة، العراق. https://orcid.org/0000-0003-4245-7618
  • Arwa H. M. AL–Saeed قسم علوم الكيمياء، كلية العلوم، جامعة البصرة، البصرة، العراق. https://orcid.org/0000-0002-6447-8965

DOI:

https://doi.org/10.21123/bsj.2023.8352

الكلمات المفتاحية:

c.TnI, CK-MB، بيتا ثلاسيميا ، اضطرابات القلب، زيادة الحديد

الملخص

بيتا ثلاسيميا هي واحدة من أكثر الأمراض الوراثية شيوعًا في العالم بسبب نقص سلاسل الكلوبين. تعتبر أمراض القلب من المضاعفات الرئيسية لهذا المرض نتيجة ترسب الحديد الزائد في أنسجة القلب. أخذ 100 مريض تتراوح أعمارهم بين 2-18 عامًا تم تشخيص إصابتهم بـ ß-TM في الدراسة الحالية التي تم قبولها في مركز ذي قار لأمراض الدم الوراثية في مدينة ذي قار بالعراق ، و80 مشاركًا سليمًا ، متطابقين مع العمر والمنطقة الجغرافية تم تبنيها كمجموعة تحكم. لتقييم مصل تروبونين 1 (c.TnI) و إنزيم الكرياتين كيناز القلبي(CK-MB)  وبروتين الابلين و انزيم اسبارتيت امينوترانسفيريز ((AST وإنزيم لاكتيت ديهايدروجينيز (LDH) للمجموعات المدروسة كشفت نتائج هذه الدراسة عن زيادة معنوية (p <0.01) في مستويات c.TnI و CK-MB و AST و LDH بالإضافة إلى انخفاض كبير (p <0.01) في مستوى الأبلين في جميع المرضى الذين يعانون من ß-TM مقارنة لمجموعة التحكم. تم العثور على معامل ارتباط بيرسون (r) أيضًا بين المعلمات البيوكيميائية التي تمت دراستها لمرضى ß-TM بمستوى الحديد، ولوحظ وجود ارتباط معنوي (p <0.01) بين مستوى الفيريتين مع مستويات CK-MB و LDH وAST. بينما لم يكن هناك ارتباط معنوي (P> 0.01) من خلال مستويات apelin و c.TnI. استنتجت الدراسة الحالية وجود مؤشر سريري لتلف أنسجة القلب على المدى القريب ، مما ينذر باستخدام بروتوكولات علاج أكثر كفاءة لإزالة الحديد الزائد من مرضى ß-TM.

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تقييم بعض انزيمات القلب والحديد في مصل مرضى بيتا-ثلاسيميا في مدينة ذي قار ، العراق. Baghdad Sci.J [انترنت]. [وثق 17 مايو، 2024];21(6). موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8352