تحضير، تشخيص فضلاً عن دراسة الفعالية البايولوجية لمعقدات بعض من ايونات الفلزات مع قواعد شيف المشتقة من 4 - امينو انتي بايرين
DOI:
https://doi.org/10.21123/bsj.2024.9204الكلمات المفتاحية:
4-aminoantipyrine ، النشاط البيولوجي ، المركب المعدني ، Polydintate ، قاعدة شيف.الملخص
قواعد شيف متعددة السن ذوات الصيغة L1= اورثو هايدروكسي انيلين -٤ - امینو انتبيرين N',N) بنزیلیدین) تم تحضيرها من تكثيف البنزايل و٤-امينو انتيبرين مع ۲-امينو فينول -۲،۱ امينو ٤ كلورو فينول بنسبة مولية (١:١:١) لكل مكون . واستخدمت هذه الليكاندات لتحضير المعقدات ذوات الصيغة [ML1 Cl]Cl و [ML2]Cl2 حيث ان Zn(II) M= Mn(II), Co(II), Ni(II),. تم استخدام التقنيات التالية لتشخيص الليكاندات والمعقدات: مطيافية الاشعة فوق البنفسجية والاشعة تحت الحمراء - المرئية وطيف الرنين النووي المغناطيسي للبروتون 1HNMR والتحليل الدقيق لايونات العناصر والكاربون والهيدروجين والنتروجين بالاضافة الى التوصيلية الكهربائية المولارية وقياسات الحساسية المغناطيسية. دلت القياسات التي تم الحصول عليها من التوصيلية الكهربائية المولارية والتي تم اجراؤها بمحلول DMSO ان جميع معقدات (L1) كانت الكتروليتية بنسبة (١:١) بينما معقدات (L2) كانت الكتروليتية بنسبة (1:2). كما اظهرت نتائج القياسات المستخدمة في هذه الدراسة ان مواقع التناسق لليكاند (L1) مع الأيون المركزي كانت من خلال ذرة الاوكسجين الفينولية وذرتين نيتروجين لمجموعتي الازوميثين اما بالنسبة لـ (L2)فبالاضافة للذرات المانحة المذكورة سابقا يتم التناسق مع ذرة الاوكسجين لمجموعة الكاربونيل الطرفية. جميع المعقدات اظهرت التناسق الرباعي بشكل هندسي رباعي السطوح ايضا تمت دراسة الفعالية البايولوجية للمركبات المحضرة ضد البكتريا موجبة الكرام (+)Staphylococcus aurous وسالبة الكرام (-) Klebsiella pneumonia.
Received 08/06/2023
Revised 31/12/2023
Accepted 02/01/2024
Published Online First 20/09/2024
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الحقوق الفكرية (c) 2024 Amera F. Mohammed, Israa A.Saeed , Khansaa Sh.AL-Nama
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