معقدات البلاديوم الثنائي لليكاندات المختلطة بنزوايزوثيازول -3 (2H) ثنائي ثايوكرباميت و الفوسفينات الثالثية : تحضيرها وتشخيصها و دراسة فعاليتها الحيوية والمضادة للسرطان

المؤلفون

  • نازك محمد عزيز قسم الكيمياء، كلية العلوم ،جامعة السليمانية،السليمانية،العراق.

DOI:

https://doi.org/10.21123/bsj.2024.9491

الكلمات المفتاحية:

الفعالية ضد السرطان، بنزوايزثايزول3-ثايوكابامات، معقدات للكيندات المختلطة، البلاديوم، الفوسفين.

الملخص

تم تحضيرالمعقد [  [Pd(bit-dtc)2من تفاعل  بنزوايزوثيازول -3 (H 2 )ثنائي ثايوكربامات الصوديوم Nabit-dtc)) مع ملح الصوديوم رابع كلوريد البلاديوم (II). وبمعاملة معقد [Pd(bit-dtc)2]  مع ثنائي الفوسفينات Ph2P(CH)nPPh2  بنسب مولية متساوية ادت للحصول على معقدات بنسب جيدة من نوع[Pd(bit-dtc)2(Ph2(CH2)nPPh2)] حيث ان n تمثل؛

   n=1(dppm)  n=2 (dppe);  n=3 (dppp);  n=4 (dppb);  n=(C5H4)2Fe (dppf).

 وقد تم تشخيص المعقدات المحضرة باستخدام التحليل الدقيق للعناصروالتحليل الطيفي للأشعة تحت الحمراء علاوة على ذلك نتائج تحليل للطيف الرنين المغناطيسي للبروتون   H- NMR 1 وP{1H}-NMR31 حيث اتضح بان ليكند الثايوكاربامات  يسلك سلوك احادي السن  مع ايون البلاديوم. ومن خلال نتائج طيف الرنين المغناطيسي تم اقترح معقدات الليكندات المختلطة لها صيغ تناسقية أحادي النواة يسلك فيها ثنائي فوسفين كلكيند كيلتي ( ثنائي المخلب) ماعدا اللكيند dppm حيث يسلك كليكند جسري وتكوين معقدات ثنائي النواة .

تم تقييم الأنشطة المضادة للميكروبات لمعقدات البلاديوم الثنائية المحضرة حديثا ضد نوعين من البكتيريا، وهما ستافيلوكوكوس اوريس (S. aureus ) وأشريشيا كولاي(E. coli ) . وتم فحص المعقدات 2 و 4 و 5 ضد سرطان البنكرياس SNU-2469))  وسرطان المعدة والمريء البشري  SK-GT-5)) وخلايا البشرية الصحية ( WRL68 ), أظهر المركب [Pd(bit-dtc)2] 2 نشاطًا ملحوظا ضد سرطان البنكرياس الغدي للخلايا السرطانية SNU-2469 بقيمة IC50حيث  تبلغ 5.067 مايكرومولر.

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كيفية الاقتباس

1.
معقدات البلاديوم الثنائي لليكاندات المختلطة بنزوايزوثيازول -3 (2H) ثنائي ثايوكرباميت و الفوسفينات الثالثية : تحضيرها وتشخيصها و دراسة فعاليتها الحيوية والمضادة للسرطان. Baghdad Sci.J [انترنت]. [وثق 21 نوفمبر، 2024];22(3). موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9491