معقدات البلاديوم الثنائي لليكاندات المختلطة بنزوايزوثيازول -3 (2H) ثنائي ثايوكرباميت و الفوسفينات الثالثية : تحضيرها وتشخيصها و دراسة فعاليتها الحيوية والمضادة للسرطان
DOI:
https://doi.org/10.21123/bsj.2024.9491الكلمات المفتاحية:
الفعالية ضد السرطان، بنزوايزثايزول3-ثايوكابامات، معقدات للكيندات المختلطة، البلاديوم، الفوسفين.الملخص
تم تحضيرالمعقد [ [Pd(bit-dtc)2من تفاعل بنزوايزوثيازول -3 (H 2 )ثنائي ثايوكربامات الصوديوم Nabit-dtc)) مع ملح الصوديوم رابع كلوريد البلاديوم (II). وبمعاملة معقد [Pd(bit-dtc)2] مع ثنائي الفوسفينات Ph2P(CH)nPPh2 بنسب مولية متساوية ادت للحصول على معقدات بنسب جيدة من نوع[Pd(bit-dtc)2(Ph2(CH2)nPPh2)] حيث ان n تمثل؛
n=1(dppm) n=2 (dppe); n=3 (dppp); n=4 (dppb); n=(C5H4)2Fe (dppf).
وقد تم تشخيص المعقدات المحضرة باستخدام التحليل الدقيق للعناصروالتحليل الطيفي للأشعة تحت الحمراء علاوة على ذلك نتائج تحليل للطيف الرنين المغناطيسي للبروتون H- NMR 1 وP{1H}-NMR31 حيث اتضح بان ليكند الثايوكاربامات يسلك سلوك احادي السن مع ايون البلاديوم. ومن خلال نتائج طيف الرنين المغناطيسي تم اقترح معقدات الليكندات المختلطة لها صيغ تناسقية أحادي النواة يسلك فيها ثنائي فوسفين كلكيند كيلتي ( ثنائي المخلب) ماعدا اللكيند dppm حيث يسلك كليكند جسري وتكوين معقدات ثنائي النواة .
تم تقييم الأنشطة المضادة للميكروبات لمعقدات البلاديوم الثنائية المحضرة حديثا ضد نوعين من البكتيريا، وهما ستافيلوكوكوس اوريس (S. aureus ) وأشريشيا كولاي(E. coli ) . وتم فحص المعقدات 2 و 4 و 5 ضد سرطان البنكرياس SNU-2469)) وسرطان المعدة والمريء البشري SK-GT-5)) وخلايا البشرية الصحية ( WRL68 ), أظهر المركب [Pd(bit-dtc)2] 2 نشاطًا ملحوظا ضد سرطان البنكرياس الغدي للخلايا السرطانية SNU-2469 بقيمة IC50حيث تبلغ 5.067 مايكرومولر.
Received 16/09/2023
Revised 10/11/2023
Accepted 12/11/2023
Published Online First 20/08/2024
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