Spexin is a Reliable Predictor of Diabetes Postmenopausal Iraqi Women: A Case-Control Study
DOI:
https://doi.org/10.21123/bsj.2024.11301Keywords:
CRP, Malondialdehyde, Spexin, Superoxide dismutase, T2DM.Abstract
A peptide called spexin (SPX) regulates blood glucose and lipid metabolism. The study primarily focused on the pathogenesis of type 2 diabetes mellitus (T2DM) in postmenopausal women, examining its relationship with serum SPX levels. A case-control study involved 180 postmenopausal women from Thi-Qar, Iraq were enrolled in the current study. Ninety women were recently diagnosed with diabetic postmenopausal women, while the other 90 were non-diabetic postmenopausal women. Blood samples were collected to test: Glycated hemoglobin (HbA1c), SPX, Malondialdehyde (MDA), Superoxide dismutase (SOD), C-reactive protein (CRP), fasting blood glucose (FSG), insulin, lipid profile and interleukein (IL-6). Results: FSG, HbA1c, insulin, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), values raised significantly (P<0.001) in T2DM postmenopausal women. Also, levels of MDA, CRP, and IL-6 dramatically elevated, and the levels of SPX and SOD significantly decreased (P<0.001). Significant lipid profile changes were observed in postmenopausal T2DM subjects. Additionally, the connection in T2DM postmenopausal women showed a negative relationship between SPX with waist-to-height ratio, SPX with FSG, SPX with HOMA-IR, MDA with SPX, as well as a positive relationship between SPX and MDA, SPX and age, CRP and IL-6, CRP and age, IL-6 and FSG, SOD and insulin. It was demonstrated that SPX is crucial to the pathogenesis of T2DM in postmenopausal women. In diabetic individuals, targeting SPX may offer a novel strategy for preserving adequate glucose control.
Received 27/03/2024
Revised 27/07/2024
Accepted 29/07/2024
Published Online First 20/12/2024
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