Evaluation of DPP4, TNF, and Lipid Profile Levels as Early Indicators in Infertility Among Iraqi Women
DOI:
https://doi.org/10.21123/bsj.2024.11669Keywords:
Dipeptidyl peptidase -4, Follicle-stimulating hormone, Infertility, Luteinizing hormone, Obesity, Testosterone, Tumor necrosis factor –α.Abstract
Infertility is one of the problems facing women and men. Obesity, lipid level disorders, and insulin resistance are among the risk factors that cause infertility, in addition to other relevant factors. The current study aimed to investigate the effect of obesity and lipids imbalance, together with studying the relationship for each dipeptidyl peptidase -4 (DPP-4) and tumor necrosis factor –α (TNF-α) infertile women compared to healthy women, to determine the possibility that they are being diagnostic and indicative factors of the disease. The study included 50 participants, age range (15-34) years, who attended Kamal Al- Samarai Hospital in Baghdad, Iraq. The participants were divided into two groups; patients group (30 infertile women) and control group (20 healthy women). Levels of fasting blood sugar (FBS), lipid profile, dipeptidyl peptidase -4 (DPP4), tumor necrosis factor –α (TNF-α), follicle-stimulating hormone (FSH), luteinizing hormone (LH), insulin and testosterone were evaluated. FBS and lipid profile levels were determined on the basis of spectrophotometric methods. Levels of DPP4, TNF-α, FSH, LH, insulin and testosterone were estimated by their ELISA kits. BMI, HOMO-IR, Atherogenic index were calculated. The results showed high levels of FBS, lipid profile (except HDL), DPP-4, TNF-α, LH, Testosterone and decrease of FSH level in patients compared to the healthy women.In conclusion, increasing lipid profile levels, obesity, atherogenic index, insulin resistance values approve the association of infertility with obesity, lipid disorders, diabetes and atherosclerosis diseases. Furthermore, DPP-4 and TNF-α are useful as good diagnostic factors for women’s infertility.
Received 29/05/2024
Revised 12/10/2024
Accepted 14/10/2024
Published Online First 20/12/2024
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