Various Extracts of Some Medicinal Plants as Inhibitors for Beta-lactamase Activity

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Huda S. A. Al-Hayanni
Hamed El-Shora

Abstract

The inhibitory effect of acetone, ethanol, and aqueous extracts of ten medicinal plants on β-lactamase from Staphylococcus sciuri and Klebsiella pneumoniae was investigated in vitro by starch-iodine agar plate method. The results revealed the success of starch-iodine method for the detection of the inhibition of β-lactamase activity by the various extracts of each individual plant. The acetone extracts of Catharanthus roseus, Eucalyptus camaldulensis, and Schinus terebinthifolius induced an inhibitory effect on β-lactamase from Staphylococcus sciuri. On the other hand, acetone extracts from only Eucalyptus camaldulensis, and Schinus terebinthifolius expressed strong inhibitory effect on β-lactamase from Klebsiella pneumoniae. The acetone extracts expressed the highest inhibition for β-lactamases activity compared to ethanolic and aqueous extracts which exhibited appreciable inhibitory effect. β-lactamase from S. sciuri was inhibited by extracts from C. roseus, E. camaldulensis and S. terebinthifolius whereas β-lactamase from K. pneumoniae was inhibited only by extracts from E. camaldulensis and S. terebinthifolius.

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S. A. Al-Hayanni H, El-Shora H. Various Extracts of Some Medicinal Plants as Inhibitors for Beta-lactamase Activity. Baghdad Sci.J [Internet]. [cited 2021Jan.20];18(1):0047. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/4478
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