Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes

Main Article Content

Amaal S. Sadiq
https://orcid.org/0000-0001-6812-0760
Zahraa T. Khudhair
https://orcid.org/0000-0003-0572-5820
Selvana A. Yousif
Wasan A. R. Mahmood

Abstract

The target of this study was to synthesize several new Ciprofloxacin drug analogs by providing a nucleophilic substitution procedure that provides new functionality at the carboxylic group location. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The synthetic path began from the reaction of ciprofloxacin drug with morpholine to give compound[B], ciprofloxacin derivative was linked with a variety of primary and secondary amines to give compounds[B1-B9]. The above-mentioned prepared compounds [B3 and B5] were applied to liver enzymes, and the increase in the activity of these enzymes was observed. In addition, a theoretical study was conducted to study the energies and properties of the prepared compounds.

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Sadiq AS, Khudhair ZT, Yousif SA, Mahmood WAR. Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes. Baghdad Sci.J [Internet]. 2022 Dec. 5 [cited 2023 Jan. 28];19(6(Suppl.):1454. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7502
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