Evaluating the Cartilage Oligomeric Matrix Protein Levels in Sera of Iraqi Patients with Rheumatoid Arthritis
DOI:
https://doi.org/10.21123/bsj.2024.9447Keywords:
Complete Blood Count, Cartilage Oligomeric Matrix Protein, C-reactive protein, Rheumatoid factor, Rheumatoid arthritis.Abstract
The biomarker significance of chemokine (Cartilage Oligomeric Matrix Protein) was evaluated in the sera of 80 rheumatoid arthritis (RA) patients and 40 control men and women. A test ELISA kit was used in the Human Reader HS apparatus to measure the serum COMP, CRP, and RF. The Nihon Kohden Europes (MEK-6550K) analyzer apparatus was used for the testing of Complete Blood Count and the erythrocyte sedimentation rate (ESR), The Westergren device was used in this evaluation. The results demonstrated that COMP, CRP, RF, and ESR showed a significantly increased median in RA patients compared to control (COMP:104.79±1.95 vs. 47.79±1.34 ng/ml; CRP: 2442.09±172.32 vs. 1271.41±35.14 pg/ml; RF: 0.92±0.03 vs. 0.34±0.024 ng/ml; ESR: 33.81±2.52 vs. 15.53±1.13 MM/H). Binary logistic regression analysis revealed that COMP was a significant predictor of RA. The ROC curve analysis also revealed that COMP recorded an area under the curve of 1.00 in RA patients. In conclusion, serum COMP is a reliable diagnostic parameter that may accurately distinguish between those with active RA and control individuals.
Received 13/09/2024
Revised 22/01/2024
Accepted 24/01/2024
Published Online First 20/07/2024
References
Giannini D, Antonucci M, Petrelli F, Bilia S, Alunno A, Puxeddu I. One year in review 2020: pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol. 2020; 38(3): 387-97. https://www.clinexprheumatol.org/article.asp?a=15504
Johnson KJ, Sanchez HN, Schoenbrunner N. Defining response to TNF-inhibitors in rheumatoid arthritis: the negative impact of anti-TNF cycling and the need for a personalized medicine approach to identify primary non-responders. Clin Rheumatol. 2019; 38(11): 2967-2976. https://doi.org/10.1007/s10067-019-04684-1
Choi HY, Cho KH, Jin C, Lee J, Kim TH, Jung WS, et al. Exercise Therapies for Parkinson's Disease: A Systematic Review and Meta-Analysis. Parkinsons Dis. 2020; 2020: 22.https://doi.org/10.1155/2020/2565320
Khanna R, Dlouhy BJ, Smith ZA, Lam SK, Koski TR, Dahdaleh NS. The impact of steroids, methotrexate, and biologics on clinical and radiographic outcomes in patients with rheumatoid arthritis undergoing fusions at the craniovertebral junction. J Craniovertebr Junction Spine. 2015; 6(2) :60–64. https://doi.org/10.4103/0974-8237.156044
Kolarz B, Ciesla M, Rosenthal AK, Dryglewska M, Majdan M. The value of anti-CarP and anti-PAD4 as markers of rheumatoid arthritis in ACPA/RF negative rheumatoid arthritis patients. Ther Adv Musculoskelet Dis. 2021; 13: 1759720X21989868.https://doi.org/10.1177/1759720X21989868
Shareef BH, Hasan BF. Status of Zinc and Selenium in Iraqi women with Rheumatoid Arthritis and secondary Osteoporosis. Biochem Cell Arch. 2021; 21(1). 1185-1194.https://connectjournals.com/03896.2021.21.1185
Mohammed RH, Farahat F, Kewan HH, Bukhari MA. Predictors of European League Against Rheumatism (EULAR) good response, DAS-28 remission and sustained responses to TNF-inhibitors in rheumatoid arthritis: a prospective study in refractory disease.Springerplus. 2015; 4(1): 207.https://doi.org/10.1186/s40064-015-0979-6
Krabbe S, Bolce R, Brahe CH, Dohn UM, Ejbjerg BJ, Hetland ML, et al. Investigation of a multi-biomarker disease activity score in rheumatoid arthritis by comparison with magnetic resonance imaging, computed tomography, ultrasonography, and radiography parameters of inflammation and damage. Scand J Rheumatol. 2017; 46(5): 353-8. https://doi.org/10.1080/03009742.2016.1211315
Posey KL, Coustry F, Hecht JT. Cartilage oligomeric matrix protein: COMPopathies and beyond. Matrix Biol. 2018; 71: 161-173.https://doi.org/10.1016/j.matbio.2018.02.023
Al-Hashimi NH, Al-Gebori AM, Alosami MHM. Evaluation of the Human Pulmonary Activation-Regulated Chemokine (CCL18/PARC) and Alkaline Phosphatase (ALP) Levels in Iraqi Patients with Rheumatoid Arthritis. Iraqi J Sci. 2020; 61(4): 713-719.https://doi.org/10.24996/ijs.2020.61.4.1
Idriss NK, Gamal RM, Gaber MA, El-Hakeim EH, Hammam N, Ghandour AM, et al. Joint remodeling outcome of serum levels of Dickkopf-1 (DKK1), cartilage oligomeric matrix protein (COMP), and C-telopeptide of type II collagen (CTXII) in rheumatoid arthritis. Cent Eur J Immunol. 2020; 45(1): 73-9. https://doi.org/10.5114/ceji.2020.94685
Christensen AF, Lindegaard H, Hørslev-Petersen K, Hetland ML, Ejbjerg B, Stengaard-Pedersen K, et al. Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis. J Rheumatol. 2011; 38(8): 1563-8.https://doi.org/10.3899/jrheum.101241
Shapiro SC. Biomarkers in rheumatoid arthritis. Cureus. 2021; 13(5):1-7. https://doi.org/10.7759/cureus.15063
Mohammed HA, Zahra’a AA, Alrawi AAO. DC-SIGN Receptor Level in Rheumatoid Arthritis Patients in Baghdad; Serological study. Baghdad Sci J. 2022; 19(6): 1212-. https://doi.org/10.21123/bsj.2022.6559
Rija FF, Hussein SZ, Abdalla MA. Physiological and immunological disturbance in rheumatoid arthritis patients. Baghdad Sci J. 2021; 18(2): 0247-. http://dx.doi.org/10.21123/bsj.2021.18.2.0247
Hassoon HJ, Jasim WE, Abbas AAH. The evaluation of some biomarkers according to rheumatoid factor in early diagnosis of Rheumatoid Arthritis from Iraqi Patients. Iraqi J Sci. 2020; 61(9): 2196-2203. https://doi.org/10.24996/ijs.2020.61.9.6
Oleiwi AR, Zgair AK. Estimation levels of CTHRC1and some cytokines in Iraqi patients with Rheumatoid Arthritis. Baghdad Sci J. 2023; 20(3 (Suppl.)): 0928-.https://doi.org/10.21123/bsj.2023.8036
Pope JE, Choy EH, editors. C-reactive protein and implications in rheumatoid arthritis and associated comorbidities. Seminars in arthritis and rheumatism; 2021: Elsevier. https://doi.org/10.1016/j.semarthrit.2020.11.005
Hamid MM, Hassan BF, Al-Hafidh AH, Muhi SA, Al-Hashemi MA. Study of Nepheroblastoma Overexpressed Protein (NOV/CCN3) as a Biomarker in Serum of Iraqi Patients with Rheumatoid Arthritis. Pak J Med Health Sci. 2022; 16(06): 460-.https://doi.org/10.53350/pjmhs22166460
Qabulio S, Shaikh F, Mirza AI, Shahid MA, Kumar S. Diagnostic Accuracy of Cartilage Oligomeric Matrix Protein (COMP), for Cartilage Damage in Rheumatoid Arthritis. J Adv Med Med Res. 2020; 32(16): 62-9. https://doi.org/10.9734/JAMMR/2020/v32i1630631
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