استكشاف الية فصل الفلوربيبروفين و النيميسوليد باستخدام كروموتوغرافيا السائل عالي الاداء ذو الطور المعكوس
DOI:
https://doi.org/10.21123/bsj.2024.10553الكلمات المفتاحية:
كروموتوغرافيا السائل عالي الاداء ذو الطور المعكوس , الادوية المضادة للالتهابات غير ستيرويدية, فلوربيبروفين نيميسوليد,المستحضرات الصيدلانية.الملخص
تهدف هذه الدراسة إلى إنشاء طريقة بسيطة لتقدير النيميسوليد والفلوربيبروفين في المستحضرات الصيدلانية. بالمقارنة مع الأساليب الأخرى، ولا سيما الطيفية، توفر كروموتوغرافيا السائل عالي الأداء ذوالطور العكسي (RP - HPLC) حساسية ودقة أكبر . التحقق من تركيز الوقاء المثالي، مستوى الحموضة ((pH، ومحتوى الأسيتونيتريل كان جزءًا من تحسين وتطوير تقنية RP-HPLC لتأكيد فصل وتقدير الدوائين المضادين للالتهابات غير ستيرويدية تقديرا كميا. حٌقق الفصل من خلال استخدام كروموتوغرافيا السائل عالي الاداء ذو الطور المعكوس مع كاشف الاشعه فوق البنفسجية والعمود المستخدم كان من نوع C8 Hyper Clone BDS ذو الابعاد((250×4.6mm,160Aᵒ,5.تم استخدام مزيج من الاسيتونيتريل ووقاء اسيتات كطور متحرك عند طول موجه مكشاف254 نانومتر وبمعدل جريان 1 مل/دقيقة. وقد بينت النتائج ملائمه الطريقه المقترحة لتقدير الدوائين المضادين للالتهابات غير ستيرويدية في المستحضرات الدوائية.
Received 29/12/2023
Revised 24/06/2024
Accepted 26/06/2024
Published Online First 20/10/2024
المراجع
Nawaz I, Tahir A, Iqbal SM, Anjum F, Naseem M, Aslam MI, et al. Anti-inflammatory, anti-nociceptive and anti-pyretic activities of Cenchrus ciliaris L. J Ethnopharmacol. 2023; 309: 116332. https://doi.org/10.1016/j.jep.2023.116332
Abdu N, Mosazghi A, Teweldemedhin S, Asfaha L, Teshale M, Kibreab M, et al. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Usage and co-prescription with other potentially interacting drugs in elderly: A cross-sectional study. PloS one. 2020; 15(10): e0238868. https://doi.org/10.1371/journal.pone.0238868
Paglia MDG, Silva MT, Lopes LC, Barberato-Filho S, Mazzei LG, Abe FC, et al. Use of corticoids and non-steroidal anti-inflammatories in the treatment of rheumatoid arthritis: Systematic review and network meta-analysis. PLoS One. 2021; 16(4): e0248866. https://doi.org/10.1371/journal.pone.0248866
Akram M, Daniyal M, Sultana S, Owais A, Akhtar N, Zahid R, et al. Traditional and modern management strategies for rheumatoid arthritis. Clin Chim Acta. 2021; 512: 142-55. https://doi.org/10.1016/j.cca.2020.11.003
Nguyen TNM, Chen L-J, Trares K, Stocker H, Holleczek B, Beyreuther K, et al. Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer’s disease in patients with coronary heart disease but not in other individuals from the general population: Results from two large cohort studies. Alzheimers Res Ther. 2022; 14(1): 75-88 .https://doi.org/10.1186/s13195-022-01017-4
Ahmad M, Subhan M. Study Of Pharmacology Effects Of Different Nsaids On Pathophysiology Of Alzheimer’s Disease. J Pharm Neg Results. 2022; 1996-2012. https://doi.org/10.47750/pnr.2022.13.S10.229
7. Wang R, Li W, Chen Z. Solid phase microextraction with poly (deep eutectic solvent) monolithic column online coupled to HPLC for determination of non-steroidal anti-inflammatory drugs. Anal Chim Acta. 2018; 1018: 111-8. https://doi.org/10.1016/j.aca.2018.02.024
Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 2020; 180: 114147. https://doi.org/10.1016/j.bcp.2020.114147
Aswaissi H, Acar ET. Simultaneous Determination of Flurbiprofen and Thiocolchicoside in Pharmaceutical Preparations by a Validated HPLC Method. J Res Pharm. 2022; 26(3): 663-74. https://doi.org/10.29228/jrp.163
Sajeev C, Jadhav PR, RaviShankar D, Saha R. Determination of flurbiprofen in pharmaceutical formulations by UV spectrophotometry and liquid chromatography. Anal Chim Acta. 2002; 463(2): 207-17. https://doi.org/10.1016/S0003-2670(02)00426-9
Rashid A, Irfan M, Kamal Y, Asghar S, Khalid SH, Hussain G, et al. In Vitro and Biological Evaluation of Oral Fast-Disintegrating Films Containing Ranitidine HCl and Syloid® 244FP-Based Ternary Solid Dispersion of Flurbiprofen. Pharmaceutics. 2024; 16(2): 164. https://doi.org/10.3390/pharmaceutics16020164
Kaduševičius E. Novel applications of NSAIDs: Insight and future perspectives in cardiovascular, neurodegenerative, diabetes and cancer disease therapy. Int J Mol Sci. 2021; 22(12): 6637. https://doi.org/10.3390/ijms22126637
Kolawole OR, Kashfi K. NSAIDs and cancer resolution: new paradigms beyond cyclooxygenase. Int J Mol Sci. 2022; 23(3): 1432. https://doi.org/10.3390/ijms23031432
Panchal NK, Sabina EP. Non-steroidal anti-inflammatory drugs (NSAIDs): A current insight into its molecular mechanism eliciting organ toxicities. Food Chem Toxicol. 2023; 172: 113598. https://doi.org/10.1016/j.fct.2022.113598
Solanki N, Gor A, Parmar B. Effectiveness And Safety Assessment Of Fixed Dose Combination Of Non-Steroidal Antiinflammatory Drugs Prescribed For Orthopedic Patients. Diabetes. 2020; 37: 24.66. https://doi.org/10.22159/ijpps.2020v12i2.35666
British Pharmacopoeia. British Pharmacopoeia Commission-The Stationery Office. 2022; 1(4): 2761.
Alsaqqa A, Hasian JA, Al-Laham AM. Simultaneous Determination of Piroxicam and Codeine Phosphate Hemihydrate in a Pharmaceutical Dosage Form Using Validated HPLC Method. Baghdad Sci J. 2023; 20(3): 681-689. .https://doi.org/10.21123/bsj.2022.7340
Elias KG, Hilal Y. Development and Validation of a Simple and Sensitive Reverse-Phase High Performance Liquid Chromatographic Method for the Determination of Ibuprofen in Pharmaceutical Suspensions. Baghdad Sci J. 2023; 20(2): 550-559. https://doi.org/10.21123/bsj.2022.6860
Ahmed SS, Rasheed AS. Comparison of ZIC-HILIC Columns for the Simultaneous Analysis of Antiviral Drugs in Dosage Forms by Hydrophilic Interaction Liquid Chromatography. Curr Pharm Anal. 2023; 19(8): 652-61. https://doi.org/10.2174/0115734129252205230920052737
Qassim B, Motelica-Heino M, Morabito D. Uptake of Three Pharmaceuticals by Beans (Phaseolus vulgaris L.) from Contaminated Soils. Baghdad Sci J. 2020; 17(3): 0733-742. https://doi.org/10.21123/bsj.2020.17.3.0733
Qasim B, Razzak AA, Kamil GM, Motelica-Heino M, Domenico M. Quantitative Determination of Fluoroquinolones in Contaminated Soils by HPLC with Solid-Phase Extraction. Baghdad Sci J. 2020; 17(1): 48-56. https://doi.org/10.21123/bsj.2020.17.1.0048
Shahriman MS, Mohamad S, Zain NNM, Alias Y, Chandrasekaram K, Raoov M. based polymeric ionic liquid for thin film micro extraction of sulfonamides in environmental water samples prior to HPLC-DAD analysis. Microchem J. 2021; 171: 106798. https://doi.org/10.1016/j.microc.2021.106798
Rasheed AS, Qassim AW, Abdulrahman SK. Development and validation of hydrophilic interaction chromatography for determination of deoxyadenosine in human serum. Int J Pharm Res. 2020; 12(2): 949-958. https://doi.org/10.31838/ijpr/2020.SP2.050
Hamed YAA-H, Rasheed AS. Zwitterionic ion chromatography coupled with ultraviolet detection for the quantification of 2-deoxyguanosine in human serum. Sys Rev Pharm. 2020; 11(3): 240-6.
Mahesh P, Haque MA, Salman BI, Belal TS, Ibrahim AE, El Deeb S. Fast and Sensitive Bioanalytical Method for the Determination of Deucravacitinib in Human Plasma Using HPLC-MS/MS: Application and Greenness Evaluation. Molecules. 2023; 28(14): 5471. https://doi.org/10.3390/molecules28145471
Ali AH. High-Performance Liquid Chromatography (HPLC): A review. Ann Adv Chem. 2022; 6: 010-20.https://doi.org/10.29328/journal.aac.1001026
Kormosh Z, Kormosh N, Lyushuk K, Semenyuk O, Kotsar V, Osyp Y, et al. Spectrophotometric Determination of Flurbiprofen in Application to Pharmaceutical Analysis. Pharm Chem J. 2022; 56(7): 999-1003 .https://doi.org/10.1007/s11094-022-02740-w
Ponnam C, Challa G, Yarraguntla S. Quantification of Flurbiprofen in Eye Drops by Stability Indicating Ultraviolet Spectrophotometric Method. Indian J Pharm Sci. 2023; 85(3): 753-760. https://doi.org/10.36468/pharmaceutical-sciences.1141
Nikolaychuk PA. UV-Spectrophotometric Determination of the Active Pharmaceutical Ingredients Meloxicam and Nimesulide in Cleaning Validation Samples with Sodium Carbonate. J Multidiscip Sci . 2023; 6(2): 248-66. https://doi.org/10.3390/j6020019
Yilmaz B, Bayrak B, Kadioğlu Y. Development and Validation of HPLC Method for the Determination of Flurbiprofen in Pharmaceutical Preparations. Int J Pharm ATA. 2022; 2(3): 72-81.
Nathi R, Kowtharapu LP, Muchakayala SK, Konduru N. QbD‐based stability‐indicating liquid chromatography (RP‐HPLC) method for the determination of flurbiprofen in cataplasm. Biomed Chromatogr. 2023; 37(4): e5580. https://doi.org/10.1002/bmc.5580
Patel Z, Tandel F, Tripathi RKP. Simultaneous estimation of propyphenazone, flurbiprofen, and their mutual prodrug by high‐performance liquid chromatography method. Sep Sci Plus. 2024; 7(1): 2300104. https://doi.org/10.1002/sscp.202300104
Waheb AA. Study the Effect of Zwitterionic Hydrophilic Interaction for Simultaneous Determination of Non-Steroidal Anti-Inflammatory Drugs in Dosage Forms. J Chem Soc Pak. 2023; 45(4): 315-322. https://doi.org/10.52568/001286/jcsp/45.04.2023
ChemAxon. Calculators and predictors 2023 .https://chemaxon.com/calculators-and-predictors
International conference on harmonization: Validation of analytical procedures: text and methodology. Geneva; 2005.
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الحقوق الفكرية (c) 2024 Bashaer A. Al-phalahy, Mustafa J. Mohammed
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