استكشاف الية فصل الفلوربيبروفين و النيميسوليد باستخدام كروموتوغرافيا السائل عالي الاداء ذو الطور المعكوس

المؤلفون

  • بشائر عباس خضير قسم الكيمياء، كلية العلوم، جامعة النهرين، بغداد، العراق.
  • مصطفى جاسم محمد قسم الكيمياء، كلية التربية ، الجامعة العراقية، بغداد، العراق.

DOI:

https://doi.org/10.21123/bsj.2024.10553

الكلمات المفتاحية:

كروموتوغرافيا السائل عالي الاداء ذو الطور المعكوس , الادوية المضادة للالتهابات غير ستيرويدية, فلوربيبروفين نيميسوليد,المستحضرات الصيدلانية.

الملخص

   تهدف هذه الدراسة إلى إنشاء طريقة بسيطة لتقدير النيميسوليد والفلوربيبروفين في المستحضرات الصيدلانية. بالمقارنة مع الأساليب الأخرى، ولا سيما الطيفية، توفر كروموتوغرافيا السائل عالي الأداء ذوالطور العكسي (RP - HPLC) حساسية ودقة أكبر . التحقق من تركيز الوقاء المثالي، مستوى الحموضة ((pH، ومحتوى الأسيتونيتريل كان جزءًا من تحسين وتطوير تقنية RP-HPLC لتأكيد فصل وتقدير الدوائين المضادين للالتهابات غير ستيرويدية تقديرا كميا. حٌقق الفصل من خلال استخدام كروموتوغرافيا السائل عالي الاداء ذو الطور المعكوس مع كاشف الاشعه فوق البنفسجية والعمود المستخدم كان من نوع C8 Hyper Clone BDS ذو الابعاد((250×4.6mm,160Aᵒ,5.تم استخدام مزيج من الاسيتونيتريل ووقاء اسيتات كطور متحرك عند طول موجه مكشاف254 نانومتر وبمعدل جريان 1 مل/دقيقة.  وقد بينت النتائج ملائمه الطريقه المقترحة لتقدير  الدوائين المضادين للالتهابات غير ستيرويدية في المستحضرات الدوائية.

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كيفية الاقتباس

1.
استكشاف الية فصل الفلوربيبروفين و النيميسوليد باستخدام كروموتوغرافيا السائل عالي الاداء ذو الطور المعكوس. Baghdad Sci.J [انترنت]. [وثق 7 نوفمبر، 2024];22(5). موجود في: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/10553