القدرة المضادة للأكسدة للمستخلص الكحولي لأوراق بينالو دوكو على مستوى SOD وعلم خلايا البنكرياس في الجرذان المصابة بداء السكري
DOI:
https://doi.org/10.21123/bsj.2024.11608الكلمات المفتاحية:
Dendrophthoe pentandra، السكري، الهيماتوكسيلين أيوزين، لانجرهانز، البنكرياس، سوبر أكسيد ديسموتاز.الملخص
يتسبب داء السكري في تلف خلايا البنكرياس والإجهاد التأكسدي بسبب عدم توازن المواد المؤكسدة ومضادات الأكسدة في الجسم. إن السيطرة على ارتفاع السكر في الدم عن طريق إعطاء الأدوية التقليدية والاستخدام طويل الأمد ينطوي على مخاطر الآثار الجانبية، لذلك يوصى بالعلاج التقليدي. بينالو دوكو (Dendophthoe pentandra (L.) Miq) هو نبات يعتبر من النباتات الطبيعية. ومع ذلك، فمن الممكن تطويره كدواء لمرض السكري لأنه يحتوي على مستقلبات يمكن استخدامها كأدوية تأتي من الطبيعة. تهدف هذه الدراسة إلى اختبار المواد الكيميائية النباتية ودراسة تأثير المستخلص الإيثانولي لأوراق بينالو دوكو (EEBD) على مستويات فوق أكسيد ديسموتاز (SOD) في فئران ويستار البيضاء المصابة بداء السكري المستحث بالستربتوزوتوسين والنيكوتيناميد، كما تم فحص مستويات الجلوكوز في الدم، بالإضافة إلى إجراء التحليل النسيجي. تحليل خلايا البنكرياس. وأظهرت نتائج الفحص الكيميائي النباتي أنها تحتوي على قلويدات وفلافونيدات وجليكوسيدات وصابونين وعفص وترايتيربينويدات. تظهر الأبحاث أن إعطاء EEBD لمدة 28 يومًا يمكن أن يقلل بشكل كبير من مستويات الجلوكوز في الدم مقارنة بمجموعة Na-CMC. زادت مستويات SOD أيضًا بقيم 30.97 ± 0.84 و 21.99 ± 0.61 و 30.52 ± 1.30 و 28.55 ± 1.30 و 28.99 ± 0.95 و 29.00 ± 0.86 بيكوغرام / مل. وأظهرت أنسجة البنكرياس أيضًا اختلافات بين النوعية والكمية، مما يشير إلى إصلاح البنكرياس وزيادة مساحة سطح جزر لانجرهانس. يتمتع هذا النبات بإمكانية تطويره ليصبح مكونًا طبيًا جديدًا يأتي من الطبيعة.
Received 21/05/2024
Revised 27/07/2024
Accepted 29/07/2024
Published Online First 20/12/2024
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الحقوق الفكرية (c) 2024 Anggun Syafitri, Yuandani, Tri Widiyawati, Dwi Rita Anggraini, Syukur Berkat Waruwu
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