التقييم المناعي الكيميائي النسيجي للـ CD63 في مرضى سرطان المعدة في العراق
محتوى المقالة الرئيسي
الملخص
يتميز CD63بأنه أحد افراد عائلة التتراسبانين البروتينية، إذ يعد سمة مميزة للحويصلات الخارجية كونه ينعدم وجوده في الانواع الاخرى من الحويصلات. يتم التعبير عنه في الاغشية الخلوية للخلايا السرطانية، فضلا عن سايتوبلازم الخلايا الحشوية (بين الخلوية). تهدف الدراسة الحالية إلى تقييم التعبير الإيجابي لـ CD63 في مرضى سرطان المعدة. وما إذا كان بالامكان استخدامه كدلالة تنبؤية للمرض. علاوة على ذلك، ايجاد العلاقة بين تعبير CD63, والمؤشرات السريرية المرضية مثل: الجنس، والعمر للمرضى، وعمق الغزو الورمي, والأنواع النسجية المختلفة للورم، واصابة العقد الليمفاوية، ودرجة تمايز الورم، ومراحل الورم (TNM). تم اجراء هذه الدراسة بأثر رجعي من الفترة الزمنية (2018-2020), على 50 مريضاً تم اختيارهم عشوائياً 10عينات كمجموعة سيطرة, و 40 عينة لمرضى سرطان المعدة) مع التقاريرالطبية والتشخيصية من مختبر علم الأمراض في مستشفى أمراض الكبد والجهاز الهضمي التعليمي, في مدينة الطب، ومن بعض المستشفيات الخاصة.تم تصبيغ المقاطع النسجية لشريحتين من كل قالب بارافيني احدها H&E والثانية بـ CD63. أما التحليل الإحصائي فقد تم انجازه بواسطة نظام SPSS عند (P ≤ 0.05). وجدت فروق معنوية ذات دلالة إحصائية بين مجموعة السيطرة، ومجموعة المرضى في التعبير الإيجابي لـ CD63، كما كان هناك ارتباط معنوي بين تعبير CD63، والأنواع النسجية للورم، وعمق الغزو الورمي، واصابة العقد الليمفاوية، والمراحل المختلفة للورم في المرضى، بينما لم يكن هناك اي فروق ذات دلالة احصائية بين عمر، وجنس المرضى، ودرجة التمايز، والتعبير الإيجابي لـCD63. تشير هذه النتائج إلى أن CD63 يمكن أن يستخدم كدلالة تنبؤية جيدة لمرضى العراق المصابين يسرطان المعدة.
Received 29/4/2021
Accepted 26/7/2021
Published Online First 20/3/2022
تفاصيل المقالة
هذا العمل مرخص بموجب Creative Commons Attribution 4.0 International License.
كيفية الاقتباس
المراجع
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