دور كل من IL-37 و Dectin-1 أثناء الإصابة بداء المقوسات
محتوى المقالة الرئيسي
الملخص
يعد داء المقوسات من الأمراض الطفيلية التي تحفز الخلايا المناعية لانتاج الحركيات الخلوية والوسائط الالتهابية المسؤولة عن حدوث الاستجابة المناعية الغير الطبيعية أو المجهضة. سلطت هذه الدراسة الضوء على تقييم مستقبلات Dectin-1 و والإنترلوكين -37 (IL-37) في مصل 80 إمراة مصابة بداء المقوسات أجهضن خلال الأشهر الثلاثة الاولى، فضلاً عن 40 إمرأة حامل في الاشهر الثلاثة الاولى وغير مصابات واستمر الحمل لديهن بنجاح (المجموعة الضابطة). في البدء تم اجراء مسح لمصل المريضات لغرض الكشف عن طبيعة الأجسام المضادة IgM و IgG للإصابة بطفيلي المقوسة الكونودية بوساطة اختبار الاليزا، ثم تم تحديد مستويات المصل لكل من IL-37 و Dectin-1. و أظهرت النتائج أن مستوى المصل من Dectin-1 قد زاد بشكل ملحوظ في جميع المرضى المصابين بداء المقوسات و الحاملين للأجسام المضادة IgM و IgG362.382 ± 45.937 و 361.916 ± 71.993 نانوغرام / لتر على التوالي، مقارنة بالمجموعة الضابطة 155.702 ± 26.356 نانوغرام / لتر. بينما كان مستوى المصل من IL-37 متقاربًا في جميع المرضى المصابين بداء المقوسات و الحاملين للاجسام المضادة IgM و IgG و كذلك مجموعة السيطرة 52.666 ± 4.272 ، 66.808 ± 9.132 و 51.984 ± 3.619 نانوغرام / لتر على التوالي ، مع عدم وجود فروق معنوية. لذلك قد يكون مستقبل Dectin-1 دورًا في فقدان الحمل خصوصاً عند الإصابة بطفيلي المقوسة الكوندية.
Received 1/9/2022
Accepted 1/11/2022
Published Online First 20/11/2022
تفاصيل المقالة
هذا العمل مرخص بموجب Creative Commons Attribution 4.0 International License.
كيفية الاقتباس
المراجع
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